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Inovio Pharmaceuticals Universal H1N1 Influenza Vaccine Achieves Protective Immune Responses Comparable to Conventional Vaccine in Phase I Study
Date:4/18/2013

an/1/86, A/Texas/36/91, A/Bayern/07/95, A/Beijing/262/95, A/New Caledonia/20/99, A/Solomon Islands/03/06, A/Brisbane/59/07, and A/California/07/09.

Demonstrating Inovio's synthetic vaccine's broad protective coverage against unmatched strains, a significant percentage of subjects immunized with lower doses of Inovio's SynCon® vaccine had an HAI titer of 1:40 or higher against each of the nine H1N1 strains tested, ranging from a 30% protective rate to the A/Solomon Islands/03/06 strain to a 70% protective rate to the A/Beijing/262/95 strain. Overall, those immunized with Inovio's vaccine at lower doses ranging from 0.3 mg to 0.9 mg generated a higher seroconversion rate (HAI titer levels associated with protection) against all of the strains except for A/California/07/09 compared to the seasonal TIV (trivalent influenza vaccine)-immunized control group.

This open label phase I study evaluated two synthetic H1N1 hemagglutinin (HA) plasmids designed to broadly protect against unmatched influenza strains within different branches of the H1N1 subtype. These plasmids were delivered in ~90 healthy adults with Inovio's CELLECTRA® intradermal electroporation device with doses of 0.3, 0.45, 0.9 and 1.8 mg separately and in combination up to three times over six months. A ten subject control group was vaccinated with a single injection of the licensed seasonal trivalent influenza vaccine targeting the matched HA antigen sequence of the currently circulating H1N1 strain, A/California/07/09.

Inovio's H1N1 DNA vaccine delivered with electroporation was well tolerated. All reported adverse events and injection site reactions were mild to moderate and required no treatment. The fa
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SOURCE Inovio Pharmaceuticals, Inc.
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