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Inovio Pharmaceuticals Universal H1N1 Influenza Vaccine Achieves Protective Immune Responses Comparable to Conventional Vaccine in Phase I Study
Date:4/18/2013

BLUE BELL, Pa., April 18, 2013 /PRNewswire/ -- Inovio Pharmaceuticals, Inc. (NYSE MKT: INO) announced today that its SynCon® universal H1N1 influenza vaccine generated protective antibody levels comparable to a current FDA-approved seasonal influenza vaccine against a currently circulating influenza strain. The SynCon® vaccine is designed to protect against a spectrum of viral strains and is not matched to the currently circulating H1N1 strain targeted by the current "conventional" vaccine. This is the first demonstration of a broadly-targeted SynCon® influenza vaccine achieving a protective immune response rate comparable to a conventional seasonal vaccine that is matched to a circulating influenza strain. The data generated in a phase 1 study of healthy volunteers (18 – 55 years) using Inovio's skin-targeted electroporation device was presented today at the World Vaccine Congress in Washington, DC, by Dr. Niranjan Sardesai , Inovio's Chief Operating Officer.

The current FDA-approved trivalent influenza vaccines are designed to protect against only the three strains included in their formulation and are therefore incapable of addressing the inevitable and frequent shift and drift of influenza viral strains that can occur from season to season. However, scientists have questioned whether an influenza vaccine designed to be broadly protective against multiple, unmatched influenza virus strains could provide the same level of protection as the currently licensed trivalent vaccines that are typically matched to two different influenza A strains and a single influenza B strain. In this 100 patient phase I study assessing multiple SynCon® DNA constructs and dose levels, 6 of 10 (60%) volunteers that received the highest (1.8 mg) dose at least two times achieved a protective HAI titer of at least 1:40 with at least a four-fold increase in titer over pre-va
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SOURCE Inovio Pharmaceuticals, Inc.
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