Navigation Links
Inovio Pharmaceuticals' Universal Avian Flu Vaccine Generates Protective Antibody Responses Against Six H5N1 Viruses in Phase I Trial
Date:5/16/2012

ypes combine with one another, which is usually the cause of pandemic influenza outbreaks. As one example of concern, a strain of the deadly influenza subtype H5N1, which has killed about 60% of everyone infected by this virus but does not currently pass easily from person to person, may combine with a strain of H1N1 or other subtype that has a high infection rate to create a more virulent new strain. In addition, several recent, controversial published studies have shown that current H5N1 viruses can be manipulated to become more infectious. There is consequently a clear need for universal influenza vaccines capable of protecting against multiple, changing strains of influenza.

Inovio's novel SynCon® vaccine design process creates a single consensus gene sequence from one or more selected antigens (e.g. HA, NA, NP) of multiple existing virus strains within each targeted influenza subtype. The vaccine based on one or more of these new gene sequences is designed to achieve cross-strain or universal protection against the natural and frequent mutations of influenza strains that will inevitably emerge within each targeted subtype. In this study, a total of 17 patients completed a full H5N1 immunization regimen consisting of two intramuscular (IM) vaccinations with a synthetic DNA vaccine encoding three flu antigens (HA, NA, NP) followed by two intradermal (ID) vaccinations of only the HA antigen using Inovio's novel skin electroporation device. The vaccine was found to be well tolerated at each immunization. Reported adverse events and injection site reactions were mild to moderate and required no treatment.

We had previously reported that two IM immunizations alone generated strong T cell immune responses against 72% of the vaccinated subjects. The T cell responses from this study mirrored the best-in-class T cell responses generated from Inovio's other Phase I SynCon® vaccine trials for HIV and cervical cancer/dysplasia.

In this final
'/>"/>

SOURCE Inovio Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Inovio Pharmaceuticals to Present at SPI 2012
2. Inovio Pharmaceuticals Reports 2012 First Quarter Financial Results
3. Inovio Pharmaceuticals Granted U.S. Patent Protection for Synthetic Vaccine for Cervical Dysplasia and Cancer
4. Inovio Receives U.S. Patent for SynCon® H1N1 Influenza Universal Vaccine
5. Inovio Pharmaceuticals to Present at Biotech Showcase Investor Conference
6. Inovio Pharmaceuticals to Present at Oppenheimer Investor Conference
7. Inovio Pharmaceuticals Closes $4.0 Million Underwritten Financing
8. Inovio Pharmaceuticals Reports 2011 Third Quarter Financial Results
9. Inovio Pharmaceuticals Cervical Dysplasia And Cancer Treatment Highlighted as One of 10 Promising Therapeutic Vaccines; Phase II Clinical Study Currently Enrolling
10. Inovio Pharmaceuticals and VGX International to Advance Therapeutic Hepatitis C and Hepatitis B Synthetic Vaccines into Clinical Studies
11. Inovio Pharmaceuticals Leadership for Life Sciences Recognized in the Philadelphia Region
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... PITTSBURGH , Aug. 29, 2014 /PRNewswire-iReach/ -- ChemImage ... at the Australian and New Zealand Forensic Science ... Forensic Sciences in Adelaide, Australia ... discussion concerning the advancements that hyperspectral imaging can ... Jeffrey Beckstead , Director of Product Development ...
(Date:8/29/2014)... , Aug. 29, 2014  Pacific Medical Data ... new website design . The main website, along ... showcases the company,s new services and content relevant to ... a new streamlined design, viewers can now better understand ... health care practices and create a more visible platform ...
(Date:8/29/2014)... , August 29, 2014 ... participate in the inaugural Tweetchat taking place in ... Worldwide , organised by UBM Live , ... #CPhIChat is a first of its kind global ... across the supply chain, aimed to stimulate conversations ...
Breaking Medicine Technology:ChemImage to Discuss Hyperspectral Imaging for Forensic Investigation at the ANZFSS 22nd International Symposium on the Forensic Sciences 2ChemImage to Discuss Hyperspectral Imaging for Forensic Investigation at the ANZFSS 22nd International Symposium on the Forensic Sciences 3PMDS Announces New Website 2CPhI Worldwide to Host #CPhIChat Provoking Debate on the Future of Pharma 2CPhI Worldwide to Host #CPhIChat Provoking Debate on the Future of Pharma 3
... Md., July 3 All newborn infants,should be ... at birth,according to a new recommendation from the ... accompanying summary of evidence appear,in the July 7 ... impaired at birth, during infancy or in early,childhood ...
... for Healthcare ... Professionals, VOORHEES, ... that causes disease with a wide spectrum of,severity, ranging from mild ... to 20% of patients who develop an initial,case of CDI.(1) These ...
Cached Medicine Technology:Task Force Recommends Screening for Hearing Loss in All Newborns 2Task Force Recommends Screening for Hearing Loss in All Newborns 3Current Concepts in Clostridium difficile Infection: A Focus on Recurrent Disease 2
(Date:8/31/2014)... Twin to twin transfusion syndrome (TTTS) ... before they were born, but an innovative fetal surgery at the ... chance at life. , Now, their parents David and Theresa Colp ... option available in St. Louis at the St. Louis Fetal Care ... Pub House (6655 Delmar Blvd, St Louis, MO 63130) on Friday, ...
(Date:8/31/2014)... Tickets for Brazil vs. Ecuador at MetLife Stadium ... is great news for diehard soccer fans who would have loved ... delight of soccer fans in the Tri-State area these two international ... 9th. , MetLife Stadium is the home field for ... National Football League. The venue opened in 2010 and has already ...
(Date:8/31/2014)... Ticket Down is a dependable source for cheap ... Sun Life Stadium in early September. Diehard soccer fans can ... September 5th between Colombia and Brazil will likely set a new ... Brazil and Honduras at Sun Life Stadium brought in excess of ... also been the home of the Florida Marlins of MLB in ...
(Date:8/31/2014)... UWDress.com, a renowned wedding dress manufacturer and retailer, ... elegant formal bridesmaid dresses today. Moreover, the ... quality special occasion outfits. All its current and prospective ... , Along with the greatly discounted prices, all ... promotional formal bridesmaid outfits are offered in over 20 ...
(Date:8/31/2014)... Recently, iFitDress.com, a well-known wedding dress manufacturer and retailer, has ... for 2014. What’s more, the firm has decided to launch ... can enjoy a low rate (up to 64 percent off) ... until September 12. , “We are happy to unveil ... home and abroad. The main purpose of the big sale ...
Breaking Medicine News(10 mins):Health News:After a Rare Diagnosis Threatened Their Boys’ Lives, Parents Build Awareness About TTTS and Fetal Surgery Options at The SSM St. Louis Fetal Care Institute. 2Health News:After a Rare Diagnosis Threatened Their Boys’ Lives, Parents Build Awareness About TTTS and Fetal Surgery Options at The SSM St. Louis Fetal Care Institute. 3Health News:Brazil vs. Ecuador Tickets MetLife Stadium: Ticket Down Slashes Ticket Prices on Ecuador vs. Brazil Tickets in East Rutherford, NJ at the MetLife Stadium 2Health News:Brazil vs. Colombia Tickets in Miami: Ticket Down Slashes Colombia vs. Brazil Tickets at Sun Life Stadium in Miami for September 5th Match 2Health News:Brazil vs. Colombia Tickets in Miami: Ticket Down Slashes Colombia vs. Brazil Tickets at Sun Life Stadium in Miami for September 5th Match 3Health News:Elegant Formal Bridesmaid Dresses Today Unveiled By UWDress.com 2Health News:Gorgeous Bridesmaid Dresses For 2014 Now Offered By iFitDress.com 2
... & Science University Knight Cancer Institute will evaluate whether ... Wash.) is as effective in delivering highly precise radiation ... has been in those with prostate cancer. , "We ... prostate cancer, and it is our hope to apply ...
... epidemicWASHINGTON, April 28 Transportation Security Officers across the country ... they screen passengers who may have been exposed to the ... an urgent letter to TSA Acting Administrator Gale Rossides, AFGE ... That a respirator, gloves and hand ...
... the facade, of the disorder, , , TUESDAY, April 28 ... genes can raise the risk for developing autism, according ... genetic roots of the disorder. , Both genes are ... complex social behavior and abstract thought, and are normally ...
... Inc. (NYSE: SFD ) today reiterated its ... or symptoms of the presence of North American influenza ... its joint ventures in Mexico. As previously announced, those ... submitting samples from their swine herds to confirm the ...
... Encryption business continues to drive performance for CompanyDALLAS, April ... ), the leader in hosted services for email encryption ... first quarter ended March 31, 2009. ZixCorp recorded ... net loss of $1.5 million for the quarter, or ...
... the country, have identified a new gene variant that is ... activity of the gene, known as CDH10, in the fetal ... regions that support language, speech and interpreting social behavior. ... edition of the journal Nature , the two findings ...
Cached Medicine News:Health News:OHSU Knight Cancer Institute to study new radiation technology for head, neck cancer 2Health News:AFGE: TSA Must Do More to Protect Its Workforce and the Public 2Health News:Research Highlights Genetic Risk for Autism 2Health News:Research Highlights Genetic Risk for Autism 3Health News:Research Highlights Genetic Risk for Autism 4Health News:Smithfield Foods Says North American Influenza Not Present in Any of Its Worldwide Operations and Pork is Safe to Eat 2Health News:Zix Corporation Reports Highest Revenue Quarter as Company Announces First Quarter 2009 Financial Results 2Health News:Zix Corporation Reports Highest Revenue Quarter as Company Announces First Quarter 2009 Financial Results 3Health News:Zix Corporation Reports Highest Revenue Quarter as Company Announces First Quarter 2009 Financial Results 4Health News:Zix Corporation Reports Highest Revenue Quarter as Company Announces First Quarter 2009 Financial Results 5Health News:Zix Corporation Reports Highest Revenue Quarter as Company Announces First Quarter 2009 Financial Results 6Health News:Zix Corporation Reports Highest Revenue Quarter as Company Announces First Quarter 2009 Financial Results 7Health News:Zix Corporation Reports Highest Revenue Quarter as Company Announces First Quarter 2009 Financial Results 8Health News:Zix Corporation Reports Highest Revenue Quarter as Company Announces First Quarter 2009 Financial Results 9Health News:Zix Corporation Reports Highest Revenue Quarter as Company Announces First Quarter 2009 Financial Results 10Health News:Zix Corporation Reports Highest Revenue Quarter as Company Announces First Quarter 2009 Financial Results 11Health News:Zix Corporation Reports Highest Revenue Quarter as Company Announces First Quarter 2009 Financial Results 12Health News:Zix Corporation Reports Highest Revenue Quarter as Company Announces First Quarter 2009 Financial Results 13Health News:Zix Corporation Reports Highest Revenue Quarter as Company Announces First Quarter 2009 Financial Results 14Health News:Zix Corporation Reports Highest Revenue Quarter as Company Announces First Quarter 2009 Financial Results 15Health News:Zix Corporation Reports Highest Revenue Quarter as Company Announces First Quarter 2009 Financial Results 16Health News:Zix Corporation Reports Highest Revenue Quarter as Company Announces First Quarter 2009 Financial Results 17Health News:World's largest DNA scan for autism uncovers new gene variant for disorder 2Health News:World's largest DNA scan for autism uncovers new gene variant for disorder 3
... The Rusch QuickTrach allows ... ventilation in the presence of ... airway obstruction. The kit consists ... unit with a 10-milliliter syringe ...
... kit includes a guarded scalpel, introducer, tracheal ... and a 10fr suction catheter., ,The ... needed to perform a cricothyrotomy., ,With ... cannula (4.0 mm I.D.) is inserted into ...
Used for emergency airway access when endotracheal intubation cannot be performed. Supplied sterile in peel-open packages. Intended for one-time use....
... Steel. Non-Sterile Howland lock handle - Chrome-plated ... high quality standard laryngoscope handles that are ... ISO 7673 standards. The designs of these ... years of use the world over to ...
Medicine Products: