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Inovio Pharmaceuticals Targets Transformation of Monoclonal Antibody Therapies
Date:9/24/2013

such as multiple sclerosis.

However, mAb technology does have limitations. Delivered by passive administration, meaning they are manufactured outside the body, they typically require costly large-scale laboratory development and production. Additional limitations include the necessity for repeat administrations and their limited length of in vivo potency.

The paradigm shift of Inovio's technology is that the DNA for a monoclonal antibody is encoded in a DNA plasmid, delivered directly into cells of the body using electroporation, and the mAbs are "manufactured" by these cells. Using this approach, the published data from this study demonstrated that a single administration of a highly optimized DNA-based monoclonal antibody in mice generated antibody molecules in the bloodstream possessing desirable functional activity including high antigen-binding and HIV-neutralization capabilities against diverse strains of HIV viruses for at least 7 days. Importantly, this DNA delivery strategy resulted in a rapid increase (i.e. in as little as 24 to 48 hours) in antibody levels in mice. All of these feats were not previously achievable with other DNA-based or viral delivery technologies. Although the published proof-of-concept experiments were specifically conducted with a VRC01 monoclonal antibody for HIV, Inovio's transformational approach could be applied to develop active monoclonal antibody products against multiple therapeutically important diseases, including cancers as well as inflammatory and infectious diseases. Combined with the significantly favorable cost structure of Inovio's DNA-based technology in comparison to conventional monoclonal antibody technology, active in-body generation of functional monoclonal antibodies in humans has the potential to significantly expand the range of targetable diseases.

"Inovio is one of the most innovative and scientifically productive biotechnology companies in our industry. Since the merger that created
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SOURCE Inovio Pharmaceuticals, Inc.
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