Navigation Links
Inovio Pharmaceuticals Targets Transformation of Monoclonal Antibody Therapies
Date:9/24/2013

such as multiple sclerosis.

However, mAb technology does have limitations. Delivered by passive administration, meaning they are manufactured outside the body, they typically require costly large-scale laboratory development and production. Additional limitations include the necessity for repeat administrations and their limited length of in vivo potency.

The paradigm shift of Inovio's technology is that the DNA for a monoclonal antibody is encoded in a DNA plasmid, delivered directly into cells of the body using electroporation, and the mAbs are "manufactured" by these cells. Using this approach, the published data from this study demonstrated that a single administration of a highly optimized DNA-based monoclonal antibody in mice generated antibody molecules in the bloodstream possessing desirable functional activity including high antigen-binding and HIV-neutralization capabilities against diverse strains of HIV viruses for at least 7 days. Importantly, this DNA delivery strategy resulted in a rapid increase (i.e. in as little as 24 to 48 hours) in antibody levels in mice. All of these feats were not previously achievable with other DNA-based or viral delivery technologies. Although the published proof-of-concept experiments were specifically conducted with a VRC01 monoclonal antibody for HIV, Inovio's transformational approach could be applied to develop active monoclonal antibody products against multiple therapeutically important diseases, including cancers as well as inflammatory and infectious diseases. Combined with the significantly favorable cost structure of Inovio's DNA-based technology in comparison to conventional monoclonal antibody technology, active in-body generation of functional monoclonal antibodies in humans has the potential to significantly expand the range of targetable diseases.

"Inovio is one of the most innovative and scientifically productive biotechnology companies in our industry. Since the merger that created
'/>"/>

SOURCE Inovio Pharmaceuticals, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Inovio Pharmaceuticals to Present at Investor Conferences and Town Hall Los Angeles
2. Roche and Inovio Pharmaceuticals partner on Inovios prostate cancer and hepatitis B immunotherapy products
3. Inovio Pharmaceuticals to Present at Upcoming Investor Conferences
4. Inovio Pharmaceuticals Malaria DNA Vaccine Demonstrates Robust Immune Responses in Animal Models
5. Inovio Pharmaceuticals Reports 2013 Second Quarter Financial Results
6. Inovio Pharmaceuticals Responds to Market Activity
7. Inovio Pharmaceuticals Potent hTERT DNA Cancer Vaccine Shows Potential to Reduce Tumors and Prevent Tumor Recurrence
8. Synthetically Optimized HIF-1 Alpha DNA Delivered with Inovios Electroporation Technology Provides Significant Therapeutic Effects for Peripheral Arterial Disease in Animal Model
9. Todays Research: Inovio Pharma, Sequenom, Peregrine Pharma, Onyx Pharma, and Optimer Pharma
10. Inovio Pharmaceuticals to Present at OneMedForumNY 2013 Investor Conference
11. Inovios Universal H7N9 DNA Vaccine Generates First Protective Antibody Responses Against Virulent H7N9 Virus in 100% of Vaccinated Animals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/6/2015)... , July 6, 2015   Cepheid (Nasdaq: ... financial results for its 2015 second quarter ended June ... close of the market. The Company will ... on Thursday, July 23, 2015, to discuss the results.  ... at http://ir.cepheid.com at least 15 minutes before ...
(Date:7/6/2015)... China , July 6, 2015 China Information ... a leading provider of integrated cloud-based platform, exchange, and ... today announced that the Company launched its mobile app ... of accessible healthcare services on mobile devices. The Company ... Health and Family Planning Bureau and Shenzhen News Net.   ...
(Date:7/4/2015)... BARCELONA , Spanje, July 4, 2015 ... SIR-Spheres® Y-90 harsmicrosferen aan eerstelijns chemotherapie voor ... de lever (mCRC) verlengt de progressievrije overleving ... met niet-resectabele, gemetastaseerde colorectale kanker (mCRC) die ... grootste verbetering gezien in progressievrije overleving (PFS) ...
Breaking Medicine Technology:CNIT Launches the Mobile App for Healthcare One Pass 2CNIT Launches the Mobile App for Healthcare One Pass 3CNIT Launches the Mobile App for Healthcare One Pass 4Nieuwe SIRFLOX onderzoeksgegevens gepresenteerd op World Congress of Gastrointestinal Cancer 2Nieuwe SIRFLOX onderzoeksgegevens gepresenteerd op World Congress of Gastrointestinal Cancer 3Nieuwe SIRFLOX onderzoeksgegevens gepresenteerd op World Congress of Gastrointestinal Cancer 4Nieuwe SIRFLOX onderzoeksgegevens gepresenteerd op World Congress of Gastrointestinal Cancer 5
... a clear victory for consumers and employers, the Maine ... law mandating fiduciary-disclosure requirements on pharmacy benefit managers (PBMs).  ... state-prescribed contract model for pharmacy benefits and also required ... and their health plan and employer clients. ...
... (NYSE: HRC ) will release its fiscal 2011 ... will host a webcast the following morning on Thursday, July ... Release:   Hill-Rom,s Fiscal 2011 Third Quarter Earnings Release for ... the public after the close of the NYSE on Wednesday, ...
Cached Medicine Technology:Win for Consumers and Payers: Maine Repeals Costly PBM Fiduciary-Disclosure Law 2Hill-Rom Holdings, Inc. Hosts Fiscal 2011 Third Quarter Earnings Webcast 2
(Date:7/7/2015)... ... July 07, 2015 , ... Clarion Safety ... has been featured in the latest issue of In Compliance Magazine, a leading ... Compliance delivers the latest news, standards updates, technical explanations and guidance, as ...
(Date:7/7/2015)... New York (PRWEB) , ... July 07, 2015 , ... ... a wide array of charitable organizations on a local, national and international level; however, ... an organization they believe will have a high impact on the beneficiaries. In September ...
(Date:7/6/2015)... ... July 06, 2015 , ... Respected southern California personal injury attorney ... marking him as an attorney who has sharp legal skills as well as a ... Award for 2015 from Martindale-Hubbell and a Top 10 Award from The National Academy ...
(Date:7/6/2015)... ... July 06, 2015 , ... In order to recognize ... Orthopaedic Society for Sports Medicine ( AOSSM ) will present ten research awards ... As a leader in orthopaedic sports medicine, AOSSM annually provides more than $350,000 ...
(Date:7/6/2015)... ... July 06, 2015 , ... Invitation to Cover: , ... is a large gap between the unmet health priorities in the region and ... and reduce unnecessary or ineffective treatments or procedures. , This milestone conference, sponsored ...
Breaking Medicine News(10 mins):Health News:Standards Considerations for Laser Safety Labels from Clarion Safety Systems Featured in In Compliance Magazine 2Health News:Standards Considerations for Laser Safety Labels from Clarion Safety Systems Featured in In Compliance Magazine 3Health News:Standards Considerations for Laser Safety Labels from Clarion Safety Systems Featured in In Compliance Magazine 4Health News:The Holiday Inn Westbury - Long Island Will Host a Fundraising Event on September 16th 2015 from 6:00 pm - 10:00 pm to Benefit Angela's House located on Long Island 2Health News:The Holiday Inn Westbury - Long Island Will Host a Fundraising Event on September 16th 2015 from 6:00 pm - 10:00 pm to Benefit Angela's House located on Long Island 3Health News:Fernando D. Vargas Awarded Top Honors in Personal Injury Law for 2015 from Two Respected Independent Organizations 2Health News:Fernando D. Vargas Awarded Top Honors in Personal Injury Law for 2015 from Two Respected Independent Organizations 3Health News:American Orthopaedic Society for Sports Medicine (AOSSM) Presents Prestigious Research Awards at Annual Meeting 2Health News:American Orthopaedic Society for Sports Medicine (AOSSM) Presents Prestigious Research Awards at Annual Meeting 3Health News:American Orthopaedic Society for Sports Medicine (AOSSM) Presents Prestigious Research Awards at Annual Meeting 4Health News:American Orthopaedic Society for Sports Medicine (AOSSM) Presents Prestigious Research Awards at Annual Meeting 5Health News:American Orthopaedic Society for Sports Medicine (AOSSM) Presents Prestigious Research Awards at Annual Meeting 6Health News:Columbia Nursing Nairobi Summit: Setting a Clinical Research Agenda for Africa 2
... -- The behavior of surgeons in the operating room affects ... also plays a part in determining health-care costs, the number ... in the July issue of The Archives of Surgery ... effectively help their patients and reduce costs. "Often, surgeons ...
... a special fascination for Marlene Zuk , world-class evolutionary ... offer us, she says, a way to understand living things ... "People have strong feelings about insects, and most of those ... at the University of California, Riverside. "But insects let ...
... Women & Infants Hospital of Rhode Island was one ... Symposium Merit Award from The Conquer Cancer Foundation of ... award, which recognizes researchers, contributions to progress against breast ... also affiliated with The Warren Alpert Medical School of ...
... researchers from the University of Oxford, Harvard Medical School ... the world,s most detailed genetic map, a tool scientists ... and how DNA is passed generationally to create diversity ... were included in a group of nearly 30,000 African-Americans ...
... Survive Overcrowding One species of bacteria have ... They change their shape. Researchers at the University ... the bacterium Paenibacillus dendritiformis uses to survive overcrowding. ... it grows it produces a toxic protein, called sibling ...
... The meteorological monster -- dubbed a "heat dome" by weather ... from the Southwest to the Ohio Valley for days, pushed ... the high 90s and heat indices surpassing 100 degrees. ... 13 deaths in the Midwest alone, is expected to break ...
Cached Medicine News:Health News:Rude Surgeons Hurt Patients, Increase Costs 2Health News:'Sex on Six Legs' is focus of UC Riverside biologist's book 2Health News:'Sex on Six Legs' is focus of UC Riverside biologist's book 3Health News:'Sex on Six Legs' is focus of UC Riverside biologist's book 4Health News:Genetic map of African-Americans to aid study of diseases, human evolution 2Health News:Genetic map of African-Americans to aid study of diseases, human evolution 3Health News:Genetic map of African-Americans to aid study of diseases, human evolution 4Health News:News tips from the journal mBio 2Health News:News tips from the journal mBio 3Health News:'Heat Dome' Continues to Throttle U.S. 2Health News:'Heat Dome' Continues to Throttle U.S. 3
... surgical approach to glaucoma management that employs ... ciliary body (which produces aqueous humour) is ... or posterior segment, through the endoscope in ... and accurately identified utilizing endoscopy. This allows ...
... (ECP) is a surgical approach to glaucoma ... laser application. The ciliary body (which produces ... from the anterior or posterior segment, through ... tissues are easily and accurately identified utilizing ...
... a surgical approach to glaucoma management that ... The ciliary body (which produces aqueous humour) ... anterior or posterior segment, through the endoscope ... easily and accurately identified utilizing endoscopy. This ...
... Centuries of German Craftsmanship have ... in the world. Ocutek® now ... Only holders of the coveted ... eight-year apprenticeship, are qualified to ...
Medicine Products: