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Inovio Pharmaceuticals Reports 2012 Fourth Quarter and Year End Financial Results
Date:3/18/2013

ref="http://ir.inovio.com/2012-12-06-Inovio-Pharmaceuticals-Announces-Positive-Interim-Results-in-Phase-II-Leukemia-Trial">reported preliminary results of a phase II clinical trial, conducted by our collaborator University of Southampton, to treat leukemia with a DNA vaccine delivered with our proprietary electroporation delivery system. The data showed robust vaccine-specific antibody responses in all vaccinated subjects evaluated to date. T-cell immune responses, including "killer T-cells," were detected.

We expect to report in 1Q 2013 interim data of a phase II clinical trial, conducted by our collaborator ChronTech Pharma AB, treating hepatitis C virus with a DNA vaccine delivered with our proprietary electroporation delivery system in conjunction with a drug regimen.

Preclinical DevelopmentInovio announced that synthetic vaccines for influenza Type A H3N2 and Type B achieved protective levels of antibody responses in immunized animals against multiple unmatched strains from the years 2000 through 2012. Inovio intends to combine these two subtypes with its H1N1 SynCon® construct to create a universal vaccine intended to provide broad protection against existing and changing seasonal and pandemic influenza strains.

We reported that our synthetic hepatitis B therapeutic vaccine generated strong T cell responses that eliminated targeted liver cells in mice. These data were published in the peer-reviewed journal, Cancer Gene Therapy.

Our testing of multiple synthetic vaccine constructs for cytomegalovirus (CMV) induced robust T cells in mice. CMV is the most common viral infection in organ transplant recipients, is associated with cerebral palsy, brain tumors, numerous inflammatory diseases and cancers, and is implicated in hypertension. These data were published in the peer-reviewed journal, 

SOURCE Inovio Pharmaceuticals, Inc.
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