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Inovio Pharmaceuticals Reports 2012 Fourth Quarter and Year End Financial Results
Date:3/18/2013

ccine against cervical dysplasias/cancers (VGX-3100) achieved an industry first when T-cell immune responses induced by this vaccine, which have been previously reported as being best-in-class, were shown to generate a strong killing effect against cells targeted by this vaccine. Based on our advanced patient enrollment, we expect unblinded data from this 148-patient Phase II clinical trial in 1Q 2014.

With respect to the universal prevention capability of our vaccine platform, we reported that in a 60-patient phase I study our H1N1 influenza vaccine generated protective immune responses against the nine key H1N1 flu strains of the past 100 years, including the 1918 pandemic flu strain. None of these viruses were matched to the vaccine. These results added to previously reported results in which our H5N1 (avian) influenza vaccine construct generated significant immune responses against six different unmatched strains of H5N1 in a 17-patient phase I study. Together these results represent an industry first and an important step toward universal preventive and/or therapeutic capabilities against mutating pathogens as well as for cancers.

In 4Q, we reported interim results (two of three arms) of a 50-patient phase I trial showing that a single dose of our H1N1 universal SynCon® flu vaccine followed by a dose of a seasonal flu vaccine generated protective immune responses in 40% of trial subjects compared with a 20% response rate in elderly patients who received the seasonal flu vaccine alone.

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SOURCE Inovio Pharmaceuticals, Inc.
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