Inovio Pharmaceuticals Reports 2011 Second Quarter Financi... (responses was similar to those observed ...)

Inovio Pharmaceuticals Reports 2011 Second Quarter Financial Results

Date:8/8/2011

responses was similar to those observed in a previous monkey study of Inovio's VGX-3100 cervical dysplasia/cancer vaccine, which is now in Phase II. The multi-antigen INO-5150 was designed with the intent to help the body's immune system overcome its "self-tolerance" of cancerous cells. Inovio plans to start a Phase I clinical trial mid-year 2012.

Inovio's subsidiary, VGX Animal Health, Inc., a developer of DNA-based vaccines and therapies for companion and food animals, reported strong T cell responses from VAH-5000D, its DNA vaccine encoding telomerase reverse transcriptase (TERT) for the treatment of dogs with cancer. Human TERT (hTERT) is also associated with human cancers.

Inovio received recognition in multiple scientific journals. Vaccine published a paper entitled "Immunogenicity of a novel engineered HIV-1 clade C synthetic consensus-based envelope DNA vaccine"; PLoS One published the paper "Long-term programming of antigen-specific immunity from gene expression signatures in the PBMC of rhesus macaques immunized with an SIV DNA vaccine." The papers were co-authored by researchers from Inovio and its academic collaborators. The data demonstrated in vaccinated animals unique immune system responses, significant antigen-specific T-cell responses, and protection from the virus.

About Inovio Pharmaceuticals, Inc. Inovio is developing a new generation of vaccines, called DNA vaccines, to treat and prevent cancers and infectious diseases. These SynCon® vaccines are designed to provide broad cross-strain protection against known as well as newly emergent strains of pathogens such as influenza. These vaccines, in combination with Inovio's proprietary electroporation delivery devices, have been shown to be safe and generate significant immune responses. Inovio's clinical programs include three separate programs in Phase II clinical studies, including VGX-3100 for treating cervical dysplasia and cancer. Other Inovio clinica
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