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Inovio Pharmaceuticals Reports 2011 Second Quarter Financial Results
Date:8/8/2011

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A subset of these Phase I participants have since been given a booster vaccination delivered with Inovio's new intradermal (ID) electroporation delivery technology. In previously published preclinical studies for flu and smallpox in monkeys, ID electroporation delivery of SynCon® DNA vaccines generated greater neutralizing antibody titers than IM electroporation and protected monkeys in influenza and smallpox challenge models. Data are expected in 4Q 2011.

Inovio also launched a second Phase I clinical study as part of its universal influenza vaccine program. This trial will assess INO-3510 SynCon® vaccine for H1N1 and H5N1 influenza using its skin-targeted ID delivery device. This Phase I trial is funded in part by a recent grant from the National Institutes of Health. All 90 subjects are currently being screened and randomized. Preliminary safety and immune response data are expected in the first quarter of 2012.

Inovio expects final data from two Phase I clinical studies of its PENNVAX™-B DNA vaccine against HIV in developed countries before the end of this year. Inovio previously reported best-in-class T cell immune responses in interim results announced last November.

Preclinical DevelopmentDuring the quarter, Inovio announced compelling immune responses in a study of its multi-subtype DNA vaccine for foot-and-mouth (FMD) disease administered with electroporation in sheep. Strong protective neutralizing antibodies were also previously observed in pigs vaccinated with the same Inovio FMD vaccine. Inovio's synthetic DNA vaccine cannot cause the disease, unlike today's FMD vaccines, providing a safe approach to potentially protect against FMD and reduce its serious impact on global food supply and commerce.

Inovio reported that its INO-5150 SynCon® therapeutic DNA vaccine for prostate cancer showed remarkably strong, antigen-specific and sustainable T cell responses in monkeys. The level of T cell
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SOURCE Inovio Pharmaceuticals, Inc.
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