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Inovio Pharmaceuticals Reports 2010 Fourth Quarter and Year End Financial Results
Date:3/17/2011

reclinical DNA Vaccine and Electroporation Device DevelopmentDuring 2010 Inovio received recognition in multiple scientific journals for various advances in its research and development programs. Examples include:

  • Molecular Therapy published a paper describing that co-delivery of Inovio's DNA-based interleukin (IL)-28B immunoadjuvant and an optimized SynCon(TM) DNA vaccine using its proprietary electroporation technology significantly enhanced antigen-specific killer T-cell responses in rhesus monkeys.
  • The Journal of Infectious Diseases published an article describing 100% protection of non-human primates against a highly pathogenic monkeypox challenge after vaccination with Inovio's smallpox DNA vaccine.
  • Gene Therapy published a paper demonstrating that a new intradermal low voltage DNA vaccine delivery device, which does not penetrate the skin, produced strong antibody and T-cell immune responses and achieved protection from lethal challenge in multiple animal models including non-human primates. This delivery method also further enhances the previously established tolerability of Inovio's electroporation devices. Inovio also made various announcements regarding other new minimally and non-invasive electroporation devices.
  • Subsequent to year end, PLoS Neglected Tropical Diseases highlighted positive results from Inovio's multi-antigen Chikungunya virus DNA vaccine, which induced robust antibody and T-cell immune responses and provided 100% protection of mice against a challenge with this tropical infectious disease. Studies in rhesus macaques demonstrated generation of strong neutralizing antibody responses which mimicked those observed in CHIKV-infected human patients who subsequently recovered from this disease.

    • Clinical DevelopmentDuring 2010, Inovio announced it achieved best-in-class immune responses in its Phase I dose escalation study of VGX-3100, its DNA vaccine
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    SOURCE Inovio Pharmaceuticals, Inc.
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