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Inovio Pharmaceuticals Receives U.S. DOD Small Business Innovation Research Grant for Multi-Vaccine DNA Delivery Device Development
Date:3/21/2011

BLUE BELL, Pa., March 21, 2011 /PRNewswire/ -- Inovio Pharmaceuticals, Inc. (NYSE Amex: INO), a leader in the development of therapeutic and preventive vaccines against cancers and infectious diseases, announced today that it has received a U.S. Department of Defense Small Business Innovation Research Grant to test the feasibility of delivering DNA vaccines by intradermal electroporation simultaneously to two or more spatially distinct sites on the body. The purpose of such a prototype device would be to mitigate potential immune interference that may result from combination vaccines that are formulated together. The device design would also facilitate rapid vaccination against multiple emerging infectious disease or pandemic threats and better meet the demands of quickly vaccinating U.S. troops stationed around the world.

Dr. J. Joseph Kim, Inovio's president & CEO, said, "This device would provide a means to painlessly deliver multiple vaccines simultaneously, bringing improved protection against infectious diseases to both military and civilian populations. This collaboration builds on Inovio's strong relationship with the U.S. Department of Defense, in which Inovio is bringing medical innovation to multiple bio-defense projects."

The research effort will seek to determine optimal spatial separation between vaccination sites on the body in order to avoid immune interference between multiple vaccines. The new specialized device resulting from this research will leverage Inovio's latest intradermal DNA vaccine delivery technology. These devices are all based on the company's proprietary electroporation delivery platform, which uses millisecond electrical pulses to dramatically improve cellular uptake of the vaccine and resulting immune responses. Final testing will involve delivery of Lassa and Hantaan virus vaccines simultaneously at spatially distinct sites. Las
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SOURCE Inovio Pharmaceuticals, Inc.
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