Navigation Links
Inovio Pharmaceuticals' Potent hTERT DNA Cancer Vaccine Shows Potential to Reduce Tumors and Prevent Tumor Recurrence
Date:7/24/2013

vade recognition by T-cells.

In the study, Inovio researchers confirmed that vaccination with Inovio's DNA vaccine delivered by adaptive electroporation induced hTERT-specific cellular immune responses with significantly greater T-cell magnitude compared to prior non-Inovio studies. Over four vaccinations there was a significant dose response, showing the value of multiple vaccinations to increase the immune response and highlighting the limitation of alternative technologies that are not amenable to multiple vaccinations such as viral vectors. Vaccination elicited multiple epitopes not only in mice, but also in monkeys, indicating a broad vaccine-induced immune response.

Study results showed that mice vaccinated with Inovio's DNA cancer vaccine and then challenged with a cancerous tumor experienced delayed tumor growth and longer overall survival compared with non-vaccinated mice. Mice first challenged with a tumor and then treated with the hTERT DNA vaccine displayed killing activity of the targeted cancer cells expressing the hTERT antigen, with no killing of normal cells that did not express the hTERT antigen. The treated mice experienced significantly smaller tumors and also longer overall survival. Vaccinated animal results were compared to a control group of animals that did not receive Inovio's DNA cancer vaccine. 

In monkeys, whose TERT is 96% similar to human TERT and therefore a highly relevant model for immunotherapeutic vaccine development, the hTERT DNA vaccine elicited strong and broad TERT-specific immune responses and demonstrated the potential to eliminate tumor cells.

Overall, in these studies researchers observed that administration of a synthetic highly optimized hTERT DNA vaccine delivered with electroporation was capable of breaking immune tolerance, and eliciting robust and diverse antigen-specific CTLs, which are responsible for clearing cancerous cells, as well as a potent antitumor response. A favorable
'/>"/>

SOURCE Inovio Pharmaceuticals, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Synthetically Optimized HIF-1 Alpha DNA Delivered with Inovios Electroporation Technology Provides Significant Therapeutic Effects for Peripheral Arterial Disease in Animal Model
2. Todays Research: Inovio Pharma, Sequenom, Peregrine Pharma, Onyx Pharma, and Optimer Pharma
3. Inovio Pharmaceuticals to Present at OneMedForumNY 2013 Investor Conference
4. Inovios Universal H7N9 DNA Vaccine Generates First Protective Antibody Responses Against Virulent H7N9 Virus in 100% of Vaccinated Animals
5. Inovio Pharmaceuticals DNA Vaccine Against Ebola and Marburg Filoviruses Provides Complete Protection in Preclinical Challenge Study
6. Inovio Pharmaceuticals Universal H1N1 Influenza Vaccine Achieves Protective Immune Responses Comparable to Conventional Vaccine in Phase I Study
7. Inovio Pharmaceuticals Recognized With "Best Therapeutic Vaccine" and "Best Early Stage Biotech" Awards at World Vaccine Congress 2013
8. Inovio Pharmaceuticals & U.S. Army Receive $3.5 Million Biodefense Grant to Further Develop Mass Vaccination Device
9. Inovio Collaborator ChronTech Reports Interim Phase II Clinical Study Results from ChronVac-C Vaccine for Hepatitis C Infection
10. Inovio Pharmaceuticals to Present at BioCenturys "Future Leaders in the Biotech Industry" Conference
11. Inovio Pharmaceuticals Reports 2012 Fourth Quarter and Year End Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... BRIDGEWATER, N.J. , Sept. 16, 2014 /PRNewswire/ ... pharmaceutical company focused on developing and commercializing therapeutic ... renal and infectious diseases, announces the amendment and ... and E preferred stock and related warrants, as ... 2014 common stock and warrant financing, to remove ...
(Date:9/16/2014)... Imprimis Pharmaceuticals, Inc. (Nasdaq: IMMY ... quality and novel medicines to physicians and patients at ... Mark Baum will be a presenter at the ... New York City.  Mr. Baum will discuss the company,s ... in ophthalmology. The presentation is scheduled for 10:40 a.m. EST ...
(Date:9/16/2014)... Sept. 16, 2014  Wearable sports and activity ... less than two years, producing a massive amount ... huge opportunity exists for leveraging this data to ... ) introduced a first-of-its-kind wearable analytics platform for ... of clinical research linking activity and health risks, ...
Breaking Medicine Technology:CorMedix Amends and Restates Outstanding Securities to Remove Provisions Causing Derivative Liability Classification 2CorMedix Amends and Restates Outstanding Securities to Remove Provisions Causing Derivative Liability Classification 3Imprimis Pharmaceuticals to Present at Craig-Hallum Alpha Select Conference 2Imprimis Pharmaceuticals to Present at Craig-Hallum Alpha Select Conference 3Imprimis Pharmaceuticals to Present at Craig-Hallum Alpha Select Conference 4Doctors Launch Initiative to Bridge Gap Between Wearables and Meaningful Health Data 2Doctors Launch Initiative to Bridge Gap Between Wearables and Meaningful Health Data 3
... WORTH, Texas, March 22, 2012  The Board of Directors of ... innovator in advanced wound care solutions, announced today that Robert ... of the Company.  In addition, Scott A. Haire has resigned ... Executive Officer of the Company, and Deborah Jenkins Hutchinson has ...
... 22, 2012  Argon Medical Devices, Inc. announced today ... catheter, licensed from Rex Medical, LP, designed to ... treatments. "UltraStream provides clinicians with an ... life for their patients," commented George Leondis, President ...
Cached Medicine Technology:Wound Management Technologies Names Robert Lutz, Jr. as New CEO; Buys Back North American Distribution Rights for CellerateRX® Powder 2Wound Management Technologies Names Robert Lutz, Jr. as New CEO; Buys Back North American Distribution Rights for CellerateRX® Powder 3Argon Medical Devices Announces The Launch of a Unique New Chronic Hemodialysis Catheter 2
(Date:9/16/2014)... September 15, 2014A prospective study that compared patient-reported ... with bone metastases demonstrates that single fraction radiation ... fraction radiation therapy (MFRT) when pain, function and ... presented today at the American Society for Radiation ... indicates that improvements in patients, pain, function and ...
(Date:9/16/2014)... Poster and Poster Discussion abstracts to be presented at ... Wednesday, 17 September 2014 at 12:00 (CEST) to give ... from the European medical oncology Congress, under the leading ... at the point where genuinely targeted therapy is now ... medicine means we are all working towards a common ...
(Date:9/16/2014)... PA (PRWEB) September 16, 2014 ... Pain Management practice by Ranking Arizona magazine, has selected ... implementation across its enterprise. , With TPC seeing ... a vast data repository that was managed through “home ... both the management and clinical leadership teams. “Our ...
(Date:9/16/2014)... Albany, New York (PRWEB) September 16, 2014 ... intelligence firm states that the global facial care market ... billion by 2019. The report, titled ‘Facial Care Market ... Facial Creams, Face Wash, Cleansing Wipes, Serums and Masks ... Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 ...
(Date:9/16/2014)... Florida Hospital announced today it is teaming up with ... become the Presenting Sponsor of the 2014-15 and 2015-16 ... wellness partner. As the Presenting Sponsor for the next ... name inclusion on all Lightning advertising campaigns and materials ... a sponsorship partner of the Lightning since 2011, and ...
Breaking Medicine News(10 mins):Health News:Single fraction RT as effective as multiple fraction RT for bone metastases 2Health News:Single fraction RT as effective as multiple fraction RT for bone metastases 3Health News:Single fraction RT as effective as multiple fraction RT for bone metastases 4Health News:ESMO 2014 Congress Preview 2Health News:The Pain Center of Arizona (TPC) Implements Analance™ BI for Actionable Intelligence 2Health News:The Pain Center of Arizona (TPC) Implements Analance™ BI for Actionable Intelligence 3Health News:Global Facial Care Market Will Report a CAGR of 6.9% between 2013 and 2019: Transparency Market Research 2Health News:Global Facial Care Market Will Report a CAGR of 6.9% between 2013 and 2019: Transparency Market Research 3Health News:Florida Hospital Teams up with the Tampa Bay Lightning as the New Presenting Sponsor of the 2014-15 and 2015-16 Lightning Seasons 2Health News:Florida Hospital Teams up with the Tampa Bay Lightning as the New Presenting Sponsor of the 2014-15 and 2015-16 Lightning Seasons 3
... business of recruiting,university students and new graduates is ... on this talent pool to,refresh the workforce with ... changed their university recruiting methods and programs,in decades ... a leading,pharmaceutical research firm., The study analyzes ...
... need to be aware of the connection, study says ... between diabetes and depression apparently cuts both ways: Not ... a heightened risk for developing depression, individuals with depression ... research revelation suggests that both doctors and patients need ...
... Foundation,announced the winners of its annual "Healthy Communities ... 10 at its offices in Edison, N.J.,Twelve New ... year,s,calendar and each received an iPOD shuffle., ... importance,of a healthy lifestyle and promotes awareness of ...
... Million in Savings in Past 4 Years, HARRISBURG, ... saving taxpayer funds, they should support,the Department of Public ... less for prescription drugs for children and families who ... Welfare,Estelle B. Richman said today., "Every budget season ...
... the University of Pennsylvania School of Medicine found that ... cell and developmental biology leads to an increase in ... therapies for lung-tissue repair after injury or disease. The ... of print publication in Nature Genetics . , ...
... Continues to Draw Top Research Institutes,Talent, and Corporate Labs That Are Looking ... ... Future, SAN DIEGO, June 17 /Xinhua-PRNewswire/ -- Singapore,s investment ... the fastest growing bioclusters in the world. R&D spending in the,biomedical sciences ...
Cached Medicine News:Health News:Best Practices: Achieving Excellence in Staffing and Recruiting Methods 2Health News:Diabetes and Depression Go Hand-in-Hand 2Health News:Diabetes and Depression Go Hand-in-Hand 3Health News:AMERIGROUP Foundation Announces Winners of 'Healthy Communities Art Project' 2Health News:PA Secretary of Public Welfare Urges General Assembly To Support Saving $100 Million Through Smarter Pharmacy Benefit Management 2Health News:PA Secretary of Public Welfare Urges General Assembly To Support Saving $100 Million Through Smarter Pharmacy Benefit Management 3Health News:Penn researchers find key developmental pathway activates lung stem cells 2Health News:Singapore Is One of the Fastest Growing Bioclusters in Asia; Wave of Investments in Drug Discovery and Translational Research 2Health News:Singapore Is One of the Fastest Growing Bioclusters in Asia; Wave of Investments in Drug Discovery and Translational Research 3Health News:Singapore Is One of the Fastest Growing Bioclusters in Asia; Wave of Investments in Drug Discovery and Translational Research 4Health News:Singapore Is One of the Fastest Growing Bioclusters in Asia; Wave of Investments in Drug Discovery and Translational Research 5Health News:Singapore Is One of the Fastest Growing Bioclusters in Asia; Wave of Investments in Drug Discovery and Translational Research 6
... ACS allows visualization of virtually the ... essentially coaxial positioning of the lens on ... detachment surgery, repairing giant retinal tears, diagnosing ... examining the peripheral retina in a vitreous ...
... somewhat higher magnification and increased ... best suited for detailed visualization ... Central Retinal is ideal for ... membrane peeling in proliferative vitreoretinopathy ...
... MiniQuad allows visualization of virtually the ... with essentially coaxial positioning of the ... excellent for retinal detachment surgery, repairing ... anterior proliferative vitreoretinopathy and for examining ...
... Lens enhances iridectomy procedures by providing ... conventional iridectomy lens designs) with exceptional ... this lens has been increased from ... The MagPlus comes standard with LaserWindow ...
Medicine Products: