Navigation Links
Inovio Pharmaceuticals' Potent hTERT DNA Cancer Vaccine Shows Potential to Reduce Tumors and Prevent Tumor Recurrence
Date:7/24/2013

vade recognition by T-cells.

In the study, Inovio researchers confirmed that vaccination with Inovio's DNA vaccine delivered by adaptive electroporation induced hTERT-specific cellular immune responses with significantly greater T-cell magnitude compared to prior non-Inovio studies. Over four vaccinations there was a significant dose response, showing the value of multiple vaccinations to increase the immune response and highlighting the limitation of alternative technologies that are not amenable to multiple vaccinations such as viral vectors. Vaccination elicited multiple epitopes not only in mice, but also in monkeys, indicating a broad vaccine-induced immune response.

Study results showed that mice vaccinated with Inovio's DNA cancer vaccine and then challenged with a cancerous tumor experienced delayed tumor growth and longer overall survival compared with non-vaccinated mice. Mice first challenged with a tumor and then treated with the hTERT DNA vaccine displayed killing activity of the targeted cancer cells expressing the hTERT antigen, with no killing of normal cells that did not express the hTERT antigen. The treated mice experienced significantly smaller tumors and also longer overall survival. Vaccinated animal results were compared to a control group of animals that did not receive Inovio's DNA cancer vaccine. 

In monkeys, whose TERT is 96% similar to human TERT and therefore a highly relevant model for immunotherapeutic vaccine development, the hTERT DNA vaccine elicited strong and broad TERT-specific immune responses and demonstrated the potential to eliminate tumor cells.

Overall, in these studies researchers observed that administration of a synthetic highly optimized hTERT DNA vaccine delivered with electroporation was capable of breaking immune tolerance, and eliciting robust and diverse antigen-specific CTLs, which are responsible for clearing cancerous cells, as well as a potent antitumor response. A favorable
'/>"/>

SOURCE Inovio Pharmaceuticals, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Synthetically Optimized HIF-1 Alpha DNA Delivered with Inovios Electroporation Technology Provides Significant Therapeutic Effects for Peripheral Arterial Disease in Animal Model
2. Todays Research: Inovio Pharma, Sequenom, Peregrine Pharma, Onyx Pharma, and Optimer Pharma
3. Inovio Pharmaceuticals to Present at OneMedForumNY 2013 Investor Conference
4. Inovios Universal H7N9 DNA Vaccine Generates First Protective Antibody Responses Against Virulent H7N9 Virus in 100% of Vaccinated Animals
5. Inovio Pharmaceuticals DNA Vaccine Against Ebola and Marburg Filoviruses Provides Complete Protection in Preclinical Challenge Study
6. Inovio Pharmaceuticals Universal H1N1 Influenza Vaccine Achieves Protective Immune Responses Comparable to Conventional Vaccine in Phase I Study
7. Inovio Pharmaceuticals Recognized With "Best Therapeutic Vaccine" and "Best Early Stage Biotech" Awards at World Vaccine Congress 2013
8. Inovio Pharmaceuticals & U.S. Army Receive $3.5 Million Biodefense Grant to Further Develop Mass Vaccination Device
9. Inovio Collaborator ChronTech Reports Interim Phase II Clinical Study Results from ChronVac-C Vaccine for Hepatitis C Infection
10. Inovio Pharmaceuticals to Present at BioCenturys "Future Leaders in the Biotech Industry" Conference
11. Inovio Pharmaceuticals Reports 2012 Fourth Quarter and Year End Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2014)... 1, 2014 In the latest call for ... dysfunction, more than 60 doctors and leading medical experts ... questioning the Food and Drug Administration,s (FDA) decision to ... of male sexual dysfunction compared with ZERO for women,s ... act for women by approving the first-ever drug to ...
(Date:8/1/2014)... 2014 In the latest call for gender ... more than 60 doctors and leading medical experts from ... the Food and Drug Administration,s (FDA) decision to approve ... male sexual dysfunction compared with ZERO for women,s most ... for women by approving the first-ever drug to treat ...
(Date:8/1/2014)... Aspire Technology Partners (Aspire) announced today that it ... This designation recognizes Aspire for delivering outstanding customer service to ... . "Achieving exceptional results for our customers is ... President and CEO of Aspire. "We are pleased Cisco has ... award and are proud to be part of the Cisco ...
Breaking Medicine Technology:60+ Healthcare Professionals Sign an Open Letter Urging the FDA to Approve First-Ever Drug to Treat Women's Most Common Form of Sexual Dysfunction, notes Even the Score 260+ Healthcare Professionals Sign an Open Letter Urging the FDA to Approve First-Ever Drug to Treat Women's Most Common Form of Sexual Dysfunction, notes Even the Score 360+ Doctors and Leading Medical Experts Sign an Open Letter Urging the FDA to Approve First-Ever Drug to Treat Women's Most Common Form of Sexual Dysfunction, notes Even the Score 260+ Doctors and Leading Medical Experts Sign an Open Letter Urging the FDA to Approve First-Ever Drug to Treat Women's Most Common Form of Sexual Dysfunction, notes Even the Score 3Aspire Technology Partners Recognized By Cisco For Excellence In Customer Satisfaction 2
... May 3, 2012 /PRNewswire-Asia/ -- Johnson & ... has acquired Guangzhou Bioseal Biotechnology Co., Ltd. ... in the design, development and commercialization of ... bleeding during surgery. The acquisition was completed ...
... Cochlear Americas , the world,s leading implantable hearing ... smartphone support application for Nucleus® Cochlear Implant recipients. ... App as part of Cochlear,s mobile support initiative, ... and wherever they need it. (Photo: ...
Cached Medicine Technology:Johnson & Johnson (China) Investment Ltd. Acquires Guangzhou Bioseal Biotechnology Co., Ltd. 2Cochlear™ Americas Adds the Nucleus® Support App to its Mobile Service Offerings 2
(Date:8/1/2014)... Medicine in St. Louis helps explain why brain tumors ... harmful than similar tumors in females. For example, glioblastomas, ... as often in males, who suffer greater cognitive impairments ... The researchers found that retinoblastoma protein (RB), a protein ... in male brain cells than in female brain cells. ...
(Date:8/1/2014)... News) -- The U.S. Food and Drug Administration announced ... to help fight type 2 diabetes. Jardiance ... treatment regimens to control blood sugar levels in the ... the Office of Drug Evaluation II in the FDA,s ... agency statement. The FDA also recommended that Jardiance ...
(Date:8/1/2014)... August 01, 2014 The evolving ... independent community pharmacies. At ThoughtSpot 2014, AmerisourceBergen and ... with practices and resources to enhance patient care ... focused on critical issues to give independent pharmacists ... grow. , ThoughtSpot show attendance experienced a ...
(Date:8/1/2014)... Texas (PRWEB) August 01, 2014 ... health coverage and healthcare reforms are boosting healthcare ... of medicines through discounts and increasing generic consumption ... at approximately 76.7 million in 2013, having grown ... 1.4%, from 2008. The implementation of the Health ...
(Date:8/1/2014)... News) -- Patients with the progressive, deadly respiratory ailment ... new weapon to battle the disease, the U.S. Food ... approved a new treatment, an inhaled spray called Striverdi ... Americans. COPD, which is often linked to smoking, involves ... Patients with COPD may experience a number ...
Breaking Medicine News(10 mins):Health News:Study reveals one reason brain tumors are more common in men 2Health News:FDA Approves New Type 2 Diabetes Drug 2Health News:ThoughtSpot 2014 Inspires as General Session Concludes 2Health News:ThoughtSpot 2014 Inspires as General Session Concludes 3Health News:ThoughtSpot 2014 Inspires as General Session Concludes 4Health News:ThoughtSpot 2014 Inspires as General Session Concludes 5Health News:Turkey Pharmaceutical and Medical Device Market Worth $21.5B & $3.3B by 2020 Respectively, Says a Report Available at MarketOptimizer.org 2Health News:Turkey Pharmaceutical and Medical Device Market Worth $21.5B & $3.3B by 2020 Respectively, Says a Report Available at MarketOptimizer.org 3Health News:Turkey Pharmaceutical and Medical Device Market Worth $21.5B & $3.3B by 2020 Respectively, Says a Report Available at MarketOptimizer.org 4Health News:FDA Approves New Treatment for People With COPD 2
... industrial chemicals in the environment can damage the developing ... deficit disorder (ADHD), and mental retardation. Still, there has ... that can cause injury to the developing brains of ... in the print issue of The Lancet researchers from ...
... 47-year-old woman who lost her hands in a chemical explosion some ... This is the first of its kind done in Spain, and ... the Pedro Cavadas Foundation performed this ten- hour operation. ... and may be released from hospital next week and should get ...
... US HIV/AIDS healthcare provider will soon be reaching out ... Assam to provide treatment and support//. ,The US-based ... counselling and testing centres in Assam's main city of ... city of Silchar. ,India's National AIDS ...
... with yet another significant product from soybean. A study ... made from soy has amazing restorative powers. ... Jefferson Medical College found that giving doses of a ... animals’ ability to move and walk. ,Over ...
... the senior citizens have become sensitive to health issues, and ... under control. ,Study author, Bernard M.Y. Cheung, said,"It ... We have tried to see if the explanation lies in ... increase in these, so probably all of these contribute in ...
... now be made more easily available to critically ill patients. ... that will enable patients// who are extremely ill to try ... options. ,The FDA has announced that they will ... to be made available to needy individuals .They will also ...
Cached Medicine News:Health News:Industrial Chemicals Are Impairing the Brain Development of Children Worldwide 2Health News:Industrial Chemicals Are Impairing the Brain Development of Children Worldwide 3Health News:Industrial Chemicals Are Impairing the Brain Development of Children Worldwide 4Health News:US NGO to Counsel HIV/AIDS Patients in Assam 2Health News:Soy’s Restorative Powers Confirme 2
The Hilan pneumatic high speed drill system consists of a pneumatic motor and drill with various cutting attachments....
The XK-95 High Speed Drill System sets new technological and performance standards for surgical drill systems....
Circular Spine Retractor System for microsurgical interventions in the lumbar and cervical spine region. The system has been approved in over 120 cases....
... The Ruggles Retractor System, a ... and the versatility of two systems ... hands from the surgical site during ... accurate retractor insertion. The retractor body ...
Medicine Products: