Navigation Links
Inovio Pharmaceuticals' Potent hTERT DNA Cancer Vaccine Shows Potential to Reduce Tumors and Prevent Tumor Recurrence
Date:7/24/2013

BLUE BELL, Pa., July 24, 2013 /PRNewswire/ -- Inovio Pharmaceuticals, Inc. (NYSE MKT: INO) announced today that in a preclinical study with two animal models, Inovio's hTERT (human telomerase reverse transcriptase) DNA cancer vaccine administered with Inovio's CELLECTRA® adaptive electroporation delivery technology generated robust and broad immune responses, broke the immune system's tolerance to its self-antigens, induced T-cells with a tumor-killing function, and increased the rate of survival. Because high levels of hTERT expression are found in 85% of human cancers, regardless of type, Inovio's cancer candidate holds the potential to perform as a "universal" cancer therapeutic based on these early but unprecedented results. Following this strong preclinical data, Inovio plans to advance its synthetic hTERT cancer vaccine, INO-1400, into clinical trials in 2014.

These results appear in the American Association for Cancer Research journal, Cancer Immunology Research, in a paper entitled: "Highly optimized DNA vaccine targeting human telomerase reverse transcriptase stimulates potent antitumor immunity," authored by Inovio researchers and collaborators.

Dr. J. Joseph Kim, Inovio's president and CEO, said: "Inovio has demonstrated in multiple published human studies that our synthetically optimized DNA vaccines delivered with our CELLECTRA delivery system generate best-in-class T-cell immune responses. Here we show that in monkeys our hTERT DNA cancer vaccine generated T-cell immune responses more than 18-fold higher than the previous best results of a peer's hTERT therapeutic vaccine, which was also a DNA vaccine delivered with electroporation. We are particularly enthusiastic about our vaccine's potential use as a "universal" cancer therapeutic, given tha
'/>"/>

SOURCE Inovio Pharmaceuticals, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Synthetically Optimized HIF-1 Alpha DNA Delivered with Inovios Electroporation Technology Provides Significant Therapeutic Effects for Peripheral Arterial Disease in Animal Model
2. Todays Research: Inovio Pharma, Sequenom, Peregrine Pharma, Onyx Pharma, and Optimer Pharma
3. Inovio Pharmaceuticals to Present at OneMedForumNY 2013 Investor Conference
4. Inovios Universal H7N9 DNA Vaccine Generates First Protective Antibody Responses Against Virulent H7N9 Virus in 100% of Vaccinated Animals
5. Inovio Pharmaceuticals DNA Vaccine Against Ebola and Marburg Filoviruses Provides Complete Protection in Preclinical Challenge Study
6. Inovio Pharmaceuticals Universal H1N1 Influenza Vaccine Achieves Protective Immune Responses Comparable to Conventional Vaccine in Phase I Study
7. Inovio Pharmaceuticals Recognized With "Best Therapeutic Vaccine" and "Best Early Stage Biotech" Awards at World Vaccine Congress 2013
8. Inovio Pharmaceuticals & U.S. Army Receive $3.5 Million Biodefense Grant to Further Develop Mass Vaccination Device
9. Inovio Collaborator ChronTech Reports Interim Phase II Clinical Study Results from ChronVac-C Vaccine for Hepatitis C Infection
10. Inovio Pharmaceuticals to Present at BioCenturys "Future Leaders in the Biotech Industry" Conference
11. Inovio Pharmaceuticals Reports 2012 Fourth Quarter and Year End Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... HAMBURG, Germany , Aug. 21, 2014  IBM (NYSE: ... Deutsches Elektronen-Synchrotron ( DESY ), a leading national research ... up management and storage of massive volumes of x-ray ... architecture based on IBM software defined technology can handle ... peak performance and help scientists worldwide gain faster insights ...
(Date:8/21/2014)... -- Zacks.com announces the list of stocks featured in the Analyst ... latest news and events impacting stocks and the financial markets. ... HPQ - Free Report ), IBM (NYSE: IBM - ... Free Report ), GlaxoSmithKline plc (NYSE: GSK - Free ... Free Report ). Today, Zacks is promoting its ...
(Date:8/21/2014)... Aug. 21, 2014  Henry Schein, Inc. (NASDAQ: ... and services to office-based dental, animal health and medical practitioners, ... conferences in September: , September 4, 2014 – ... , NY at 12:50 p.m. ET , September 8, 2014 ... New York , NY at 1:25 p.m. ET ...
Breaking Medicine Technology:DESY and IBM Develop Big Data Architecture for Science 2DESY and IBM Develop Big Data Architecture for Science 3The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 2The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 3The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 4The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 5The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 6The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 7The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 8The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 9The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 10The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 11Henry Schein To Present At Two Investor Conferences In September 2
... InCode BioPharmaceutics, Inc.,an emerging biopharmaceutical company, today ... their lead drug candidate rC3-1 for,the treatment ... nocturnal,hemoglobinuria (PNH). The complete results will be ... Basel, Switzerland, September 28,2008., The only ...
... a leading innovator,of physiological monitoring solutions for more ... with its breakthrough technology to measure,regional oxygen saturation. ... continuous monitoring of the regional blood oxygenation,in the ... and outcomes from an ongoing clinical study at ...
Cached Medicine Technology:InCode BioPharmaceutics, Inc. Announces Key Data Supporting New Treatment of Paroxysmal Nocturnal Hemoglobinuria (PNH) 2Nonin Medical Inc. Announces Entry Into the Cerebral Oximeter Market 2
(Date:8/21/2014)... Living in a quality residential community means ... with it. A quality Home Owners Association like the ... available. , Simpson Mill Plantation, ... Association Management, LLC made a recent investment in a ... an additional amenity for their neighborhood. , Situated near ...
(Date:8/21/2014)... 21, 2014 Recently, Van Uden ... patients. Alternative medicine is on the rise and ... According to The Fiscal Times, young people are ... conventional medicine. , The Fiscal Times published an ... are embracing alternative medicine. The article can be ...
(Date:8/21/2014)... the coronary arteries of chronic kidney disease patients may ... to a new study in the Journal of ... Researchers at the Johns Hopkins Bloomberg School of Public ... used measures of subclinical atherosclerosis in predicting the risk ... Approximately 50 percent of all patients with chronic kidney ...
(Date:8/21/2014)... cancer appear to have better survival if they ... Author: Uchechukwu C. Megwalu, M.D., M.P.H., of the ... York, and colleagues. , Background: Approximately 11,000 to ... year and squamous cell carcinoma accounts for the ... total surgical removal of the larynx with postoperative ...
(Date:8/21/2014)... Improv performers from Fun House Theatre and Film ... Turtle Creek memory care community in Dallas. The Unicorn ... ages 10 to 16, delivers a groundbreaking and fun-filled ... troupe's philosophy is that improv is based on relationships, ... audiences regardless of their circumstance — including bringing joy ...
Breaking Medicine News(10 mins):Health News:Recreation is the Heart of the Community at Simpson Mill Plantation; Chooses American Parks Company™ for New Playground Equipment 2Health News:Recreation is the Heart of the Community at Simpson Mill Plantation; Chooses American Parks Company™ for New Playground Equipment 3Health News:Van Uden Center Sees Growth in Alternative Medicine 2Health News:Measuring calcium buildup to predict heart disease in those with chronic kidney disease 2Health News:Surgery associated with better survival for patients with advanced laryngeal cancer 2Health News:Unicorn Clearance Improv Troupe Brings Laughter to Residents with Dementia at Silverado Memory Care 2
... Citizens by Enhancing Their ... Own Plans, ... help them prepare for one of the most daunting public,health emergencies: an ... Policy (CIDRAP) at,the University of Minnesota and the Pew Center on the ...
... Organization Urges Consumers to ... Beware!, ... Society of Cosmetic Dermatology and Aesthetic,Surgery (ASCDAS), responded to the recent decision ... of Healing Arts to ban the,liposuction treatment, Lipodissolve. "This procedure is still ...
... or circulating tumour cells (CTCs), are known to be associated ... Now, for the first time, a group of scientists have ... chemotherapy treatment and hence may be able to identify those ... such treatment in future. , Dr. Julia Jckstock, from the ...
... Driven by Launches, of Disease-Modifying Therapies, According to a New ... ... Resources, WALTHAM, Mass., Sept. 24 Decision Resources, one of ... that by 2016 Genentech/Roche,s Lucentis and Eli,Lilly,s ruboxistaurin will drive the ...
... DUBLIN, Ohio, Sept. 24 Cardinal Health, a,global provider ... of health care, today announced President and Chief Executive,Officer ... effective Nov. 8,following the company,s 2007 annual shareholder meeting. ... who plans to retire,at the end of the company,s ...
... University of Warwick, and University College London, have found that ... death from cardiovascular disease. However they have also found that ... double the risk of death. , In research to be ... Society, Professor Francesco Cappuccio from the University of Warwicks Warwick ...
Cached Medicine News:Health News:Peer-Reviewed, Online Database Showcases Local, County and State Pandemic Planning 2Health News:Peer-Reviewed, Online Database Showcases Local, County and State Pandemic Planning 3Health News:Peer-Reviewed, Online Database Showcases Local, County and State Pandemic Planning 4Health News:Peer-Reviewed, Online Database Showcases Local, County and State Pandemic Planning 5Health News:Lipodissolve - Is it Safe??? 2Health News:Cancer cells in blood can identify risk of recurrence in breast cancer 2Health News:Cancer cells in blood can identify risk of recurrence in breast cancer 3Health News:Genentech/Roche's Lucentis and Eli Lilly's Ruboxistaurin Will Drive the Diabetic Retinopathy and Nephropathy Drug Markets 2Health News:Cardinal Health Names CEO R. Kerry Clark as Chairman; Company Founder Robert D. Walter to Retire After 36 Years 2Health News:Cardinal Health Names CEO R. Kerry Clark as Chairman; Company Founder Robert D. Walter to Retire After 36 Years 3Health News:Researchers say lack of sleep doubles risk of death... but so can too much sleep 2
BioSoft alcohol gel hand antiseptic with soothing moisturizers is a fast-acting, broad-spectrum antimicrobial solution. BioSoft alcohol gel hand antiseptic applies easily, requires no rinsing and dri...
... Scrub Care povidone-iodine (PVP-I) antimicrobial solutions ... control in all hospital and health-care settings. ... gel have a broad spectrum of activity, ... bacteria that may cause infection. The new ...
... hand sanitizers like Aplicare No Rinse Isopropyl ... as the recommended product for hand disinfection ... Guidelines for hand hygiene., According to the ... be prevented with better infection control programs. ...
This is long known for its purity and mildness, Castile Soap is also an effective cleaning agent that is used in a variety of applications. It rinses clean while leaving the skin soft and healthy....
Medicine Products: