Navigation Links
Inovio Pharmaceuticals HPV Immunotherapy Achieves Primary Efficacy Endpoint in Randomized Phase II Cervical Dysplasia Trial
Date:7/23/2014

PLYMOUTH MEETING, Pa., July 23, 2014 /PRNewswire/ -- Inovio Pharmaceuticals, Inc. (NYSE MKT: INO) today announced successful results from its randomized, double-blind, placebo-controlled phase II trial of VGX-3100 in women with biopsy-proven cervical intraepithelial neoplasia 2/3 (CIN2/3) associated with human papillomavirus (HPV) types 16 or 18. Treatment with VGX-3100, Inovio's HPV16/18-specific immunotherapy, resulted in histopathological regression of CIN2/3 to CIN1 or no disease, meeting the study's primary endpoint. In addition, the trial demonstrated clearance of HPV in conjunction with regression of cervical lesions. Robust T-cell activity was detected in subjects who received VGX-3100 compared to those who received placebo.

"This is a significant step toward providing women and their physicians a non-surgical approach to the treatment of precancerous lesions by stimulating their immune system to eliminate high risk HPV infection and induce regression of a cervical intraepithelial neoplastic process," said Mark Bagarazzi, MD, Chief Medical Officer, Inovio Pharmaceuticals. "This proof of concept trial will guide the advancement of VGX-3100 for precancerous dysplasias as well as HPV-associated cervical, head and neck, and anogenital cancers."

Treatment was randomized 3:1 between the VGX-3100 and placebo groups, and was stratified by age and severity of CIN. The primary endpoint, histologic regression, was evaluated 36 weeks after the first treatment. In the per protocol analysis, CIN2/3 resolved to CIN1 or no disease in 53 of 107 (49.5%) women treated with VGX-3100 compared to 11 of 36 (30.6%) who received placebo. This difference was statistically significant (p<0.025).

Virological clearance of HPV 16 or 18 from the cervix in conjunction with histopathological regression of cervical dysplasia to CIN1 or no disease, a secondary endpoint of the trial, was observed in 43 of 107 (
'/>"/>

SOURCE Inovio Pharmaceuticals, Inc.
Copyright©2014 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Inovio Pharmaceuticals Granted U.S. Patent Protection for Synthetic Vaccine for Cervical Dysplasia and Cancer
2. Inovio Pharmaceuticals Reports 2012 First Quarter Financial Results
3. Inovio Pharmaceuticals to Present at SPI 2012
4. Inovio Pharmaceuticals Universal Avian Flu Vaccine Generates Protective Antibody Responses Against Six H5N1 Viruses in Phase I Trial
5. Inovio Pharmaceuticals to Present at JMP Investor Conference
6. Inovio Initiates H1N1 Universal Influenza Vaccine Clinical Trial Targeting Over-65 Population, Which Represents 90% of Flu Deaths
7. Inovio Pharmaceuticals Inc. to Webcast, Live, at RetailInvestorConferences.com on August 2nd
8. Inovio Pharmaceuticals Inc. Investor Presentation Now Available for On-demand Viewing at RetailInvestorConferences.com
9. Inovio Pharmaceuticals Reports 2012 Second Quarter Financial Results
10. Inovio Pharmaceuticals Takes Major Stride Toward Universal Influenza Vaccine
11. Inovio Pharmaceuticals Reports 2012 Third Quarter Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2015)... -- Boston Scientific Corporation (NYSE: BSX ) is scheduled ... Healthcare Conference on May 6 in Boston ... and chief financial officer, and Susie Lisa , vice ... answer session regarding the company with the host analyst at ... the presentation and question and answer session will be available ...
(Date:4/24/2015)... 2015  Novartis Pharmaceuticals Corporation (NPC) has been named the ... row on the annual DiversityInc Top 50 Companies for Diversity ... Companies for Diversity on April 23 at an awards ceremony ... ranked second on the DiversityInc Top 10 Companies for Recruitment ... Resource Groups list. David Epstein , ...
(Date:4/24/2015)... 2015 /CNW/ - T-Bird Pharma Inc. (TSXV:TPI) ("T-Bird" or ... quality medical marijuana products and a licensed producer ("LP") ... Regulations ( Canada ) ("MMPR"), is pleased ... shareholders, has closed the transaction announced on March 11, ... (the "Escrow Transfer") a total of 20,156,790 common shares ...
Breaking Medicine Technology:Boston Scientific To Participate In The Deutsche Bank 40th Annual Healthcare Conference 2Novartis Pharmaceuticals Corporation is first company to receive number one ranking two years in a row on DiversityInc Top 50 Companies for Diversity list 2Novartis Pharmaceuticals Corporation is first company to receive number one ranking two years in a row on DiversityInc Top 50 Companies for Diversity list 3Novartis Pharmaceuticals Corporation is first company to receive number one ranking two years in a row on DiversityInc Top 50 Companies for Diversity list 4T-Bird Pharma Inc. Announces Closing of Transaction with Medna Biosciences 2T-Bird Pharma Inc. Announces Closing of Transaction with Medna Biosciences 3
... 2011 On Wednesday, April 27 at 11 a.m., ... Langevin, Governor Lincoln Chafee, Lieutenant Governor Elizabeth H. Roberts, ... at its headquarters at 211 Circuit Drive in North ... Peter F. Kilmartin will tour Dominion,s laboratory at 1 ...
... JACKSON, Wis., April 25, 2011 Wisconsin Pharmacal Company, ... market recall of Triad Povidone Iodine Prep Pads, manufactured ... names including Triad. The Triad Povidone Iodine Prep Pads ... distributed by Wisconsin Pharmacal Company. In the interest of ...
Cached Medicine Technology:Dominion Diagnostics Celebrates National Medical Laboratory Professionals Week with Rhode Island Elected Officials 2Important Information for Atwater Carey First Aid Kit Consumers Regarding Triad Group's Povidone Iodine Prep Pads 2
(Date:4/24/2015)... York, NY (PRWEB) April 24, 2015 ... sober living residence in Westchester County. Just 35 miles ... help transition individuals back into everyday life while recovering ... Thursday, May 7, 2015, will allow therapists, doctors and ... areas and learn more about the opportunities offered by ...
(Date:4/24/2015)... Foothill Ranch, California (PRWEB) April 24, 2015 ... that has a wide range of capabilities and services ... etc. , Ryadon's Quantity Discount Program will be ... ) as follows: , Order 4-19: Receive 10% discount ... Can Benefit by Using the Drawer Slides Products, ...
(Date:4/24/2015)... York (PRWEB) April 24, 2015 ... move forward in the federal multidistrict litigation underway ... According to court documents, the parties involved in ... April 16th detailing, among other things, preparation for ... that counsel for both plaintiffs and defendants have ...
(Date:4/24/2015)... The first step to transforming one’s life ... meditation and yoga teacher Stine Koppernæs, meditation and changing ... that allow her to experience more peace and freedom ... teacher since 2006, and through the years she has ... , “I love sharing this way of finding true, ...
(Date:4/24/2015)... Anchor Health Administrators (Anchor), specialists in Long-Term Care ... exclusive agreement with LTC Solutions for All LLC (SFA) ... , Anchor has more than 18 years of experience ... and is currently the designated advocate for the American ... member benefit. , “I am very pleased to be ...
Breaking Medicine News(10 mins):Health News:Constellations Recovery Opens The First Luxury Sober Living Residence in Westchester New York 2Health News:Constellations Recovery Opens The First Luxury Sober Living Residence in Westchester New York 3Health News:Ryadon Inc. Offers Quantity Drawer Slide Discount Program Nationwide in May 2015 2Health News:Ryadon Inc. Offers Quantity Drawer Slide Discount Program Nationwide in May 2015 3Health News:Federal Lipitor Lawsuits Progress, as New Status Report Details Preparation for Upcoming Bellwether Trials 2Health News:Federal Lipitor Lawsuits Progress, as New Status Report Details Preparation for Upcoming Bellwether Trials 3
... Millions of Americans have an undiagnosed artery disorder that can ... study reveals. The disorder is fibromuscular dysplasia, an accumulation ... narrow. The condition can occur in any artery but occurs ... to 4 percent of Americans. If untreated, fibromuscular dysplasia ...
... request that the journals Science and ... modified H5N1 virus because of biosecurity concerns does not ... They caution, however, that a fair, transparent process ... on disseminating scientific information., Writing in Science , ...
... are not as fit as earlier generations, and even the ... of inactivity could have a major long-term health impact. ... on a survey of Norwegian schoolchildren,s performance in the 3 ... Leif Inge Tjelta and Sindre Dyrstad at the University of ...
... , ROCHESTER, Minn. -- Results of two studies suggest ... developed in a collaboration between Mayo Clinic and Exact ... significantly more sensitive than other noninvasive tests at detecting ... important implications for clinicians and tens of thousands of ...
... of new federal legislation, electronic health records (EHRs) are ... nurses the frontline providers of care. In the ... University of Pennsylvania School of Nursing determined that nurses ... care and better health outcomes for patients than nurses ...
... investigational drug called regorafenib slowed the progression of tumors and ... , an international phase III clinical trial found. The findings ... the American Society of Clinical Oncology in San Francisco ... , principal investigator of the trial in the United States. ...
Cached Medicine News:Health News:Narrowed Artery Condition Often Goes Undiagnosed: Study 2Health News:Balancing scientific freedom and national security 2Health News:Balancing scientific freedom and national security 3Health News:Sitting it out 2Health News:Sitting it out 3Health News:New test offers greater accuracy in early detection of colorectal cancer 2Health News:New test offers greater accuracy in early detection of colorectal cancer 3Health News:Better together - The RN and the EHR 2Health News:Drug improves survival of colorectal cancer patients, trial results show 2
... Super Pulse sealed CO2 surgical lasers offer ... the experience and support services of a ... laser experience. All settings are available at ... MD Super Pulse surgical lasers are compatible ...
... and targeting make treatment quick and effective ... cone angle, adjustable offset and variable pulse ... on the most modern IOLs without damage ... optics ensure low energy plasma formation with ...
... Pentacam images the anterior segment of the ... This rotating process supplies pictures in three ... measured very precisely because of this rotational ... than two seconds and minute eye movements ...
... SP-2000P Non -Contact Specular Microscope is ... and versatility in non-contact specular microscopy. ... Topcon's Imagenet system. Dual measurement system: ... 3D auto alignment and auto capture ...
Medicine Products: