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Inovio Pharmaceuticals' Dual-Antigen SynCon™ DNA Vaccine for Prostate Cancer Induces Robust Responses in Preclinical Trial
Date:2/2/2011

ons of highly optimized DNA vaccine delivered by electroporation. Immunogenicity was evaluated one week after the second vaccination. The resultant data showed the induction of strong PSA and PSMA-specific cellular immune responses and also significant antigen specific seroconversion, illustrating that both humoral and cellular immune responses can be generated by this approach.

Inovio previously collaborated with the UK's University of Southampton and Institute of Cancer Research in a study evaluating a DNA vaccine for prostate cancer delivered using Inovio's electroporation delivery technology. The published data from this phase I/II study of a DNA vaccine encoding for human PSMA generated proof-of-concept levels of both antibody and T-cell immune responses in the 30 patients vaccinated in this study.

These proof-of-concept results have recently been supported by positive immunology data from Inovio's phase I clinical study of its multi-antigen SynCon™ DNA vaccine against cervical dysplasias (VGX-3100). In this study, all three dose groups experienced significant antigen-specific antibody and T-cell immune responses against multiple antigens. In the third and final dose group, five of six (83%) patients developed the highest level of T-cell responses achieved by any non-replicating vaccine platform in patients to date.

Dr. J. Joseph Kim, Inovio's President and CEO, said: "This is an important study in which the first SynCon™ DNA vaccine against a cancer target was successfully tested. This immunotherapy targeting more than a single antigen as a treatment for prostate cancer generated strong antibody and T-cell immune responses, which are considered vital to addressing prostate cancer. Taken together with the previous preclinical and clinical data, the current published results support the advancement of this product into a Phase I clinical study."

Inovio's electroporation-based DNA vaccine delivery technology, employed in
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SOURCE Inovio Pharmaceuticals Inc.
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