Navigation Links
Inovio Pharmaceuticals' Dual-Antigen SynCon™ DNA Vaccine for Prostate Cancer Induces Robust Responses in Preclinical Trial
Date:2/2/2011

ons of highly optimized DNA vaccine delivered by electroporation. Immunogenicity was evaluated one week after the second vaccination. The resultant data showed the induction of strong PSA and PSMA-specific cellular immune responses and also significant antigen specific seroconversion, illustrating that both humoral and cellular immune responses can be generated by this approach.

Inovio previously collaborated with the UK's University of Southampton and Institute of Cancer Research in a study evaluating a DNA vaccine for prostate cancer delivered using Inovio's electroporation delivery technology. The published data from this phase I/II study of a DNA vaccine encoding for human PSMA generated proof-of-concept levels of both antibody and T-cell immune responses in the 30 patients vaccinated in this study.

These proof-of-concept results have recently been supported by positive immunology data from Inovio's phase I clinical study of its multi-antigen SynCon™ DNA vaccine against cervical dysplasias (VGX-3100). In this study, all three dose groups experienced significant antigen-specific antibody and T-cell immune responses against multiple antigens. In the third and final dose group, five of six (83%) patients developed the highest level of T-cell responses achieved by any non-replicating vaccine platform in patients to date.

Dr. J. Joseph Kim, Inovio's President and CEO, said: "This is an important study in which the first SynCon™ DNA vaccine against a cancer target was successfully tested. This immunotherapy targeting more than a single antigen as a treatment for prostate cancer generated strong antibody and T-cell immune responses, which are considered vital to addressing prostate cancer. Taken together with the previous preclinical and clinical data, the current published results support the advancement of this product into a Phase I clinical study."

Inovio's electroporation-based DNA vaccine delivery technology, employed in
'/>"/>

SOURCE Inovio Pharmaceuticals Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. University of Southampton and Inovio Pharmaceuticals Initiate Phase 2 Clinical Study to Evaluate Leukemia DNA Vaccine Using Electroporation Delivery Technology
2. Inovio Pharmaceuticals Closes $24.3 Million Registered Offering
3. Dr. Peter Thompson Joins Anthera Pharmaceuticals Board of Directors
4. Transdel Pharmaceuticals Announces Exploration of Strategic Alternatives
5. Valeant Pharmaceuticals to Acquire PharmaSwiss S.A.
6. Vanda Pharmaceuticals Files Shelf Registration Statement
7. Endo Pharmaceuticals Announces Receipt of Paragraph IV Certification
8. Endo Pharmaceuticals and Orion Corporation Begin Novel R&D Collaboration
9. Lotus Pharmaceuticals Provides Inner Mongolia Land Price Guidance from Cha You Qian Qi Government
10. JHP Pharmaceuticals and Putney Inc. Announce Multi-Year Contract Manufacturing Agreement
11. AVANIR Pharmaceuticals Invites Investors to Fiscal 2011 First Quarter Conference Call
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... BOSTON , Aug. 29, 2014   Vittamed Corporation ... Boston announced today that T. (Teo) Forcht ... to the company,s Board of Directors. " ... distinguished career in neurosurgery, medical innovation and venture capital," said ... are extremely delighted to add his clinical, strategic, and entrepreneurial ...
(Date:8/29/2014)... Pa. , Aug. 29, 2014  Unilife Corporation ... UNS) announced today that it intends to release its ... year ended June 30, 2014 after market trading ends ... has scheduled a conference call for 4:30 p.m. U.S. ... 2014 at 6:30 a.m. AEST), to review the Company,s financial ...
(Date:8/29/2014)... , Aug. 29, 2014  In part four ... leverage a hospital pharmacy as a strategic asset, ... practice leader for Cardinal Health,s Innovation Delivery Solutions business, ... can benefit both hospitals and patients. "Every ... one part of their job in a value-based healthcare ...
Breaking Medicine Technology:Vittamed Adds Prominent Neurosurgeon and Venture Capitalist T. Forcht Dagi to Board of Directors 2Unilife Corporation to Announce Financial Results for Fiscal Year 2014 Fourth Quarter and Year End on Tuesday, September 9, 2014 2Five Ways Hospital Pharmacies Can Fulfill Their Quality Care Mission 2Five Ways Hospital Pharmacies Can Fulfill Their Quality Care Mission 3Five Ways Hospital Pharmacies Can Fulfill Their Quality Care Mission 4
(Date:9/2/2014)... Recently, Os-Monitor.com, an innovative company that provides many kinds ... employee internet monitoring products ( http://www.os-monitor.com ). Furthermore, the ... 10% off, on these useful items. , True ... different kinds of high end monitoring programs on its ... of all sizes. With its high end programs, the ...
(Date:9/2/2014)... Kicking blog MichaelHusted.com is featuring an interview ... role as a kicking coach, his kicking business, and on ... retired NFL kicker Michael Husted author of HustedKicking.com. , "Anthony ... one of the top pro free agent kickers out there,” ... at our 2014 Pro Camp and I was impressed with ...
(Date:9/2/2014)... simple awareness campaign in general practice identifies new cases ... ESC Congress today by Professor Jean-Marc Davy from France. ... most common cardiac arrhythmia. It multiplies the risk of ... stroke risk by five-fold. Similarly, AF is responsible for ... is often overlooked and diagnosed too late. In 20% ...
(Date:9/2/2014)... 2 September 2014: Health structures explain nearly 20% ... to the results of a joint ESC-OECD study ... Maggioni. Clinical variables explained more than 80% of ... unique evaluation which combines clinical data and health ... fuller picture of the reasons some patients with ...
(Date:9/2/2014)... (PRWEB) September 02, 2014 Developers and ... announced a new ProIntro Lesson from Pixel Film Studios. ... easy and fresh-looking titles,” said Christina Austin, CEO of ... armature, ProIntro is a definite game changer.” , Learn ... ProIntro Lesson from Pixel Film Studios. ProIntro is a ...
Breaking Medicine News(10 mins):Health News:Useful Employee Internet Monitoring Products Now For Sale At Os-Monitor.com 2Health News:MichaelHusted.com Features Interview with Anthony Cantele of Cantele Kicking on His Role as a Kicking Coach and on Becoming a National Camp Series (NCS) Associate 2Health News:MichaelHusted.com Features Interview with Anthony Cantele of Cantele Kicking on His Role as a Kicking Coach and on Becoming a National Camp Series (NCS) Associate 3Health News:Simple awareness campaign in general practice identifies new cases of AF 2Health News:Health structures explain nearly 20 percent of non-adherence to heart failure guidelines 2Health News:Pixel Film Studios Released a New ProIntro Lesson Exclusively for Final Cut Pro X 2Health News:Pixel Film Studios Released a New ProIntro Lesson Exclusively for Final Cut Pro X 3
... new bladder cancer therapy show promising interim results. Lead ... drug Urocidin follows thirty years of his research in ... results of the trial," says Dr. Morales, professor emeritus ... director of the Queen,s University Centre for Applied Urological ...
... crashes each year. As a result, most states have put laws ... cell phones and PDAs while driving. But a new study led ... distracted driving and the laws being passed to address the problem. ... Journal of Preventive Medicine , is the first comprehensive collection and ...
... improve their outcomes if they walk briskly for at least ... recent study in Cancer Research , a journal of ... that men who walk briskly after their diagnosis may delay ... Erin Richman, Sc.D., a research associate at the University of ...
... MA May 24, 2010 CardioCareLive, the world,s ... Johns Hopkins University School of Medicine, today announced ... to be held over two days on Tuesday ... of interest to cardiovascular care and internal medicine ...
... 24, 2011 The latest episode in the ... Global Challenges/Chemistry Solutions ," focuses on new blood ... infected with an antibiotic-resistant bacterium that,s become a ... "superbug" is called methicillin-resistant Staphylococcus aureus, or simply ...
... , TUESDAY, May 24 (HealthDay News) -- Rain-making bacteria ... particles play in the Earth,s precipitation cycle, new research ... at the general meeting of the American Society for ... within the center of hailstones, suggesting that airborne microorganisms ...
Cached Medicine News:Health News:New made-in-Canada therapy for bladder cancer shows promising results 2Health News:Temple-led study finds widening gap between distracted driving and legislation 2Health News:Brisk walking could improve prostate cancer outcomes 2Health News:CME on atrial fibrillation, interventional cardiology and lipids online at CardioCareLive 2Health News:CME on atrial fibrillation, interventional cardiology and lipids online at CardioCareLive 3Health News:New American Chemical Society podcast: Fast test to diagnose MRSA infections 2Health News:Airborne Germs May Spur Rain, Snow, Hail 2
... Graham-Field has been developing ... than 58 years. Our medical-surgical ... reputation for innovation, quality and ... brands include the Labtron® line ...
... a spill-proof design and effective output, even ... All medical nebulizers are free-standing for easy ... are available., ,All Portex® medication nebulizer ... nebulizers feature consistently fine misting and the ...
... held at angles up to 45° without sacrificing ... column, finger grooves for a non-slip gripping surface, ... of regular oxygen tubing. The large diffuser ... sustain optimum mist concentration at every setting. ...
... and Respiratory Products, ,Westmed designs, manufacturers ... Anesthesia and Respiratory professionals. Our mission is ... the clinician's ability to deliver quality medical ... bottom line. , ,Our web site ...
Medicine Products: