Navigation Links
Inovio Pharmaceuticals Completes PENNVAX™-B HIV Vaccine Phase I Study, Demonstrates Best-in-Class T-Cell Immune Responses
Date:9/14/2011

AX™-B vaccine, and 30 subjects received a 3 mg dose of PENNVAX™-B along with 1 mg of GENEVAX™IL-12 DNA. All volunteers received vaccine or placebo administered via intramuscular injection with electroporation at months 0, 1, and 3. The T-cell immune responses were detected using a validated flow cytometry-based intracellular cytokine staining (ICS) assay at the HVTN core immunology laboratory at the Fred Hutchinson Cancer Research Center (Seattle, WA).

These data indicate that antigen-specific T-cell responses were generated by the vaccine in a majority of subjects. Overall, either CD4+ or CD8+ or both T-cell responses were observed against at least one of the vaccine antigens in 83.3% (30 of 36) of evaluated subjects after three vaccinations using electroporation. The response rate increased to 88.9% (24 of 27) of evaluated subjects after three vaccinations with electroporation plus the IL-12 cytokine gene adjuvant. The investigators in this study concluded that PENNVAX™-B + IL-12 plasmid delivered via electroporation led to frequencies and magnitudes of cellular immune responses equal to or greater than those reported from current vector-based HIV vaccines such as adenovirus or traditional DNA vaccination without electroporation. Further trials delivering an HIV DNA vaccine using electroporation with or without IL-12 as a vaccine strategy are merited.

Specifically, after three vaccinations with the PENNVAX™-B vaccine given with IL-12 and electroporation:

  • Antigen-specific CD4+ T-cell responses were generated by the vaccine in 80.8% of evaluated vaccine recipients (21 of 26).
  • Significantly strong antigen-specific, CD8+ T-cell responses were also generated by the vaccine in 51.9% of evaluated vaccine recipients (14 of 27).
  • In an assessment of immune response durability out to six months post dose 3, 53.6% (15 of 28) of the subjects maintained positive CD4+ T-cell responses and 42.9% (12 of 28) of
    '/>"/>

  • SOURCE Inovio Pharmaceuticals, Inc.
    Copyright©2010 PR Newswire.
    All rights reserved

    Page: 1 2 3 4 5 6

    Related medicine technology :

    1. Inovio Pharmaceuticals Adds Two Medical Innovators to Its Scientific Advisory Board
    2. Inovio Pharmaceuticals to Present at Investor Conferences
    3. Inovio Pharmaceuticals Reports 2011 Second Quarter Financial Results
    4. Inovio Pharmaceuticals Demonstrates Positive Immune Responses in Phase I Clinical Trial of SynCon™ H5N1 Influenza Vaccine and Launches Multi-Subtype Influenza Vaccine Phase I
    5. Inovio Pharmaceuticals Announces Transition of Avtar Dhillon to Non-Executive Chairman of the Board
    6. Inovio Pharmaceuticals to Present at Scientific & Industry Conferences
    7. Inovio Pharmaceuticals Subsidiary, VGX Animal Health, to Present at VetHealth Global 2011, June 14-17, 2011
    8. Inovio Pharmaceuticals to Present at American Society of Gene & Cell Therapy Annual Meeting May 18 - 21, 2011
    9. Inovio Pharmaceuticals Market-Leading Intellectual Property Recognized by MDB Capital Award
    10. Inovio Pharmaceuticals to Present at Investor Conferences
    11. Inovio Pharmaceuticals, Transgene and ChronTech Pharma to Collaborate on Heterologous Prime-Boost Therapeutic Vaccination Against Hepatitis C
    Post Your Comments:
    *Name:
    *Comment:
    *Email:
    (Date:9/30/2014)...  Decision Resources Group finds that the Asia Pacific ... China , India , ... through 2023. Dental implant procedure volumes will grow as physicians are ... Other key findings from Decision Resources Group,s coverage of the ... , Dental implant penetration: Penetration of dental implants among the ...
    (Date:9/30/2014)... -- Alimera Sciences, Inc. (NASDAQ: ALIM ) (Alimera), ... and commercialization of prescription ophthalmic pharmaceuticals, announced today that ... Technology Growth Capital, Inc. (NYSE: HTGC ) ... under the Loan and Security Agreement that Alimera,s subsidiary ... Sciences Limited, entered into with Hercules in April of ...
    (Date:9/30/2014)... 2014 The Chinese wound care market is ... in the incidence of lifestyle diseases, coupled with the ... of better quality of wound care products provide the ... of public health insurance schemes and increased reimbursement rate ... on the findings of primary and secondary researches, this ...
    Breaking Medicine Technology:Asia Pacific Dental Implant Market Will Grow at a Strong Rate Through 2023 2Asia Pacific Dental Implant Market Will Grow at a Strong Rate Through 2023 3Alimera Sciences Receives $25 Million Advance from Hercules Technology Growth Capital 2China Wound Care Market 2China Wound Care Market 3
    ... HAYWARD, Calif., Feb. 1, 2011 Anthera Pharmaceuticals, Inc. ... drugs to treat serious diseases associated with abnormal auto-immune ... Dr. Peter Thompson to its Board of Directors. Currently, ... is the founder and Managing Director of Strategicon Partners, ...
    ... Mich., Feb. 1, 2011 Stryker Corporation (NYSE: ... previously announced sale of its OP-1 product family, which ... use in orthopaedic bone applications. The transaction also includes ... Stryker is one of the world,s ...
    Cached Medicine Technology:Dr. Peter Thompson Joins Anthera Pharmaceuticals Board of Directors 2
    (Date:10/1/2014)... Marriagelifeinsurance.com has released a new blog post explaining how ... Senior citizens can purchase a joint life insurance policy ... joint policy is cheaper, but will only pay benefits ... insurance can be used to cover important funeral expenses. ... as the application process is simple and straightforward. ...
    (Date:10/1/2014)... Lifeinsurance-policy.com has released a new blog post ... for smokers. , Smoking will always have a negative ... the best method to find affordable coverage. Insurance brokerage ... coverage. , Whole life insurance premiums will be ... the coverage is permanent, the initial rates are ...
    (Date:10/1/2014)... ATLANTA (PRWEB) October 01, 2014 ... executive networking and relationship-marketing firm, announced today ... Security Executive® and Project of the Year ... decision makers representing organizations in financial services, ... include large-scale technology endeavors that address key ...
    (Date:10/1/2014)... DURHAM, N.C. A new genetic finding from Duke ... hostility, anxiety and depression might also be hard-wired to ... diabetes and heart disease. , An estimated 13 percent ... the genetic susceptibility, and knowing this could help them ... healthy diet, exercise and stress management. , "Genetic susceptibility, ...
    (Date:10/1/2014)... Innovations announces the upcoming airing of Innovations with ... 20, 2014 at 7:30 a.m. EST/PT via Discovery Channel. ... scenes to learn about Break the Cycle’s comprehensive dating ... help and information Break the Cycle provides to teens ... abuse, how to navigate the legal system, and provides ...
    Breaking Medicine News(10 mins):Health News:Elderly Life Insurance - Find Life Insurance for Retired Couples! 2Health News:Affordable Whole Life Insurance Premiums for Smokers! 2Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 2Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 3Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 4Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 5Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 6Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 7Health News:Gene interacts with stress and leads to heart disease in some people 2Health News:Innovations to Explore Breakthroughs in Health and Wellness in Upcoming Episode Airing Monday, October 20, 2014 via Discovery Channel 2
    ... ... its new home at the UCSF Mission Bay campus near downtown San Francisco. , ... (Vocus) June 22, 2010 -- UCSF ... new home at the UCSF Mission Bay campus near downtown San Francisco. The gift is ...
    ... ... Support Initiatives , ... Santa Clara, Calif. (PRWEB) June 22, 2010 -- Aerohive Networks, creators of the ... joined the company as Vice President of Technical Operations. Jiang will report directly to ...
    ... Physicist David William Townsend will be honoured with the ... for the design, commercial development and clinical implementation of ... medal jointly with his co-inventor, engineer Ronald Nutt, on ... Montreal, Quebec, Canada. IEEE is the world,s largest ...
    ... Park, MD (June 22, 2010) -- The Human Genome Project, ... of hundreds of animal, plant, fungal, and microbe genomes in ... data with which researchers are struggling to keep pace. Knowing ... that genes play in the actual manifestation of physical traits ...
    ... ... risk management to be integrated on MetricStream GRC Platform , ... (PRWEB) June 22, 2010 -- SunTrust Banks, ... leader in Governance, Risk, Compliance (GRC) solutions, to integrate audit, compliance and risk ...
    ... ... the word about HIV prevention. , ... Chicago, IL (PRWEB) June 22, 2010 -- STDTestExpress , a service dedicated to ... HIV test with the purchase of an 8 Test Panel – a savings of $50. The ...
    Cached Medicine News:Health News:UCSF Children's Hospital Receives $100 Million Gift To Build New Hospital 2Health News:UCSF Children's Hospital Receives $100 Million Gift To Build New Hospital 3Health News:UCSF Children's Hospital Receives $100 Million Gift To Build New Hospital 4Health News:UCSF Children's Hospital Receives $100 Million Gift To Build New Hospital 5Health News:Aerohive Networks Appoints Dr. Lin Jiang as Vice President of Technical Operations 2Health News:Aerohive Networks Appoints Dr. Lin Jiang as Vice President of Technical Operations 3Health News:A*STAR scientist receives international award for innovation in healthcare technology 2Health News:New genetic analysis reveals principles of phenotypic expression 2Health News:MetricStream Selected by SunTrust for Enterprise-Wide GRC 2Health News:MetricStream Selected by SunTrust for Enterprise-Wide GRC 3Health News:STDTestExpress Highlights National HIV Testing Day with Free HIV Testing 2Health News:STDTestExpress Highlights National HIV Testing Day with Free HIV Testing 3
    Adjustable wire speculum with 17 mm open blades. Lid tension adjustable throughout procedure with thumb screw control. Shaft angled 45 degrees. Manufactured in titanium....
    Solid 13.5 mm wide by 5 mm deep blades. Edge of blades serrated. Dull finish....
    Adjustable lid speculum angled 45 degrees with 17 mm curved solid blades and aspiration ports to remove excess fluid from around the eye during ocular procedures....
    Open 11 mm blades. Dull finish. Most popular size or model....
    Medicine Products: