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Inovio Pharmaceuticals Completes PENNVAX™-B HIV Vaccine Phase I Study, Demonstrates Best-in-Class T-Cell Immune Responses
Date:9/14/2011

BLUE BELL, Pa., Sept. 14, 2011 /PRNewswire/ -- Inovio Pharmaceuticals, Inc. (NYSE Amex: INO), a leader in the development of synthetic immunogens against cancers and infectious diseases, announced today that it has achieved best-in-class immune responses in a Phase I clinical study of PENNVAX™-B, its product for the prevention of the HIV sub-type prevalent in the US and Europe. These end of study results were presented at the AIDS Vaccine Conference in Bangkok, Thailand.

Dr. Spyros Kalams, Associate Professor of Medicine Vanderbilt University Medical Center and principal investigator of Vanderbilt's HIV Vaccine Trials Unit and of this clinical study, said, "These data show for the first time that HIV-specific immune responses may be enhanced with DNA and a plasmid cytokine adjuvant (IL-12) delivered via electroporation. The results of this study represent a significant advance for the ability of a DNA based vaccine to generate high levels of immune responses against HIV antigens and is transformative for DNA vaccination."

The HVTN-080 Phase I study enrolled 48 healthy, HIV-negative volunteers to assess safety and levels of immune responses generated by Inovio's PENNVAX™-B vaccine delivered with its CELLECTRA® electroporation device. PENNVAX™-B consists of SynCon® immunogens targeting HIV gag, pol, and env proteins from HIV subtype B commonly found in North America and Europe. This randomized, double-blind, multi-center study was sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), an agency of the National Institutes of Health, and conducted by the NIAID-funded HIV Vaccine Trials Network (HVTN) at several clinical sites.

Of the 48 total volunteers, eight subjects received a placebo, 10 subjects received a 3 mg dose (1 mg dose of each of three DNA plasmids – gag, pol, env) of Inovio's SynCon® PENNV
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SOURCE Inovio Pharmaceuticals, Inc.
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