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Inovio Pharmaceuticals Cervical Dysplasia And Cancer Treatment Highlighted as One of 10 Promising Therapeutic Vaccines; Phase II Clinical Study Currently Enrolling
Date:10/31/2011

responses to VGX-3100. Subjects will also be monitored for tolerability and safety. See the HPV-003 clinical trial protocol.

About Fierce VaccinesFierce Vaccines is a weekly update on the vaccine industry with a special focus on the innovations revolutionizing the development and production of vaccines. Fierce Vaccines reaches corporate executives and R&D leaders at vaccine developers and pharmaceuticals of all sizes. Editorial topics include vaccine R&D, sales and marketing, research breakthroughs, vaccine production, disruptive technologies, and next-generation vaccine therapeutics. Fierce Vaccines is one of the publications offered by Fierce Markets, whose newsletters deliver crucial industry news and insightful analysis to over a million industry leaders each day. http://www.fiercevaccines.com.

About VGX-3100Inovio's VGX-3100 is designed to raise immune responses against the E6 and E7 oncogenes common to HPV types 16 and 18, i.e. it targets four antigens. These oncogenes are responsible for transforming HPV-infected cells into pre-cancerous and cancerous cells. The goal is to stimulate a T-cell immune response strong enough to cause the rejection of these infected or transformed cells from the body. The potential of such a therapeutic vaccine would be to treat precancerous dysplasias (CINs), cervical cancers, as well as other anogenital and head and neck cancers caused by these HPV types.

About Cervical Dysplasias/Cancers Human papillomavirus (HPV) is the causative agent responsible for most cases of cervical cancer. At any given time, approximately 10% of women worldwide are infected with HPV. While roughly 70% of HPV infections are cleared by the body on its own, persistent HPV can lead to dysplasia, or premalignant changes in cells, of the cervix. Resea
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SOURCE Inovio Pharmaceuticals, Inc.
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