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Inovio Pharmaceuticals Cervical Dysplasia And Cancer Treatment Highlighted as One of 10 Promising Therapeutic Vaccines; Phase II Clinical Study Currently Enrolling
Date:10/31/2011

uce the encoded antigenic protein and so trigger production of antibodies and T-cells against that target. In the case of VGX-3100, intramuscular injections deliver DNA for the proteins E6 and E7, which are known to inactivate two of the body's natural tumor suppressor proteins."

Inovio recently reported data demonstrating long-term durability of T cell immune responses of up to over two years in 87% (7 of 8) of evaluated patients following a fourth vaccination of VGX-3100. The data further highlighted the viability of using multiple booster vaccinations with a synthetic vaccine delivered using electroporation, in contrast to other non-replicating vaccine vectors that may induce unwanted immune responses against the vector after multiple vaccinations. The vaccine generated best-in-class T cell immune responses, which are widely believed to be important in clearing cancerous cells. VGX-3100 recently won the Edward Jenner Poster Award First Prize, a prestigious award that recognized the most promising research at the 5th Vaccine and ISV Global Congress.

Inovio's president and CEO, J. Joseph Kim, said, "We greatly appreciate recognition from a top-tier pharmaceutical publication for Inovio's leadership in developing a therapeutic vaccine against precancerous and cancerous cells of the cervix. Inovio's synthetic vaccine for cervical dysplasias/cancer answers an unmet need by providing a non-invasive and potentially more effective approach for treating women with this condition - there is neither a therapeutic live virus vaccine nor non-replicating vaccine available for cervical dysplasias and cancers."

Inovio is currently recruiting for its Phase II study, which is designed to enroll 148 patients with cervical dysplasia at approximately 25 study centers. This randomized, placebo-controlled study will assess regression of cervical lesions from CIN 2/3 or CIN 3 to CIN 1 or less and clearance of HPV 16 or 18. The secondary endpoint is to assess immune
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SOURCE Inovio Pharmaceuticals, Inc.
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