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Inovio Initiates H1N1 Universal Influenza Vaccine Clinical Trial Targeting Over-65 Population, Which Represents 90% of Flu Deaths
Date:7/10/2012

tailed clinical study protocol.

Dr. Gary P. Kobinger, Chief, Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, and a principal investigator of his study, said, "There have been limited new vaccine innovations with the potential to better protect the elderly against influenza. We are pleased to conduct this trial to evaluate this potential breakthrough influenza vaccine technology."

Dr. J. Joseph Kim, Inovio's President and CEO, said, "We recently reported protective levels of immune responses against six unmatched strains of influenza in our H5N1 clinical study and expect data in the third quarter from our second influenza study, which includes an H1N1 component and is being tested in a population less vulnerable to influenza. Having achieved best-in-class T-cell responses against other diseases, we will also assess T-cell generation against influenza, which is widely believed to be an important avenue to increasing protection for the highly at-risk 65-plus population."

With the vulnerability of elderly in mind, this clinical study will assess the ability to generally induce stronger antibody responses; provide universal cross-strain protection; and stimulate a part of the immune system not triggered by conventional influenza vaccines, the cellular immune response that generates CD8+ killer T-cells.

About SynCon® Influenza Vaccines and this Clinical Trial Design

The strategy to combine an influenza DNA vaccine prime with a conventional seasonal vaccine boost is based on the idea that combining the different modalities of Inovio's SynCon® flu vaccine's ability to generate cross-protective antibody and T-cell responses with the conventional seasonal flu vaccine in a prime-boost regimen could generate a stronger and broader antibody response in the elderly.

Inovio's SynCon® i
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SOURCE Inovio Pharmaceuticals, Inc.
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