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Inovio Initiates H1N1 Universal Influenza Vaccine Clinical Trial Targeting Over-65 Population, Which Represents 90% of Flu Deaths
Date:7/10/2012

BLUE BELL, Pa., July 10, 2012 /PRNewswire/ -- Inovio Pharmaceuticals, Inc. (NYSE MKT: INO) announced today that the first patients have been treated in a clinical trial evaluating immune responses in elderly adults immunized with Inovio's H1N1 SynCon® universal influenza vaccine. This phase I study will evaluate the ability of Inovio's SynCon® vaccine alone as well as in combination with the 2012 seasonal influenza vaccine to generate: protective levels of immune responses; antigen-specific antibody immune responses against unmatched influenza strains; and T-cell immune responses that may be helpful in fighting influenza.

The population most susceptible to influenza, those over 65 years of age, represent about 90% of annual influenza deaths in the US. Older people's immune systems typically mount weaker immune responses to vaccines. There is consequently a need for new vaccine technology able to stimulate a broader immune response that is capable of protecting against influenza strains not specifically matched to the strain(s) represented in the vaccine.

The phase I open label study will take place at the University of Manitoba in Winnipeg, Canada, funded in part by a grant from the Canadian Institute of Health Research. In the trial, 50 healthy elderly patients will be divided into three groups: One group of 20 subjects will receive a 2 dose regimen of Inovio's H1N1 SynCon® flu vaccine delivered using Inovio's proprietary CELLECTRA® intradermal electroporation device; a second group of 20 subjects will receive one dose of Inovio's SynCon® vaccine delivered using electroporation followed by a dose of the 2012 trivalent seasonal flu vaccine 24 weeks later; a third group  of 10 subjects will receive a placebo delivered by electroporation followed by a dose of the seasonal flu vaccine 24 weeks later. The study will assess the tolerability, safety, and the immune responses of the different vaccination regimens. See the de
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SOURCE Inovio Pharmaceuticals, Inc.
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