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Innovations and Opportunities in Therapeutic Vaccines: Technology Platforms, Key Players, and Early Pipeline Candidates
Date:11/8/2010

210

Celprogen 211

Creagene 211

Dendreon 211

Entest 212

Geron 213

GlobeImmune 214

Gradalis 216

Heat Biologics 217

ImmunoCellular Therapeutics 217

ImmunoVentis 218

King's College, London 219

Morphogenesis 219

Multimmune 220

Newcastle University 220

NewLink Genetics 221

Northwest Biotherapeutics 222

NovaRx 223

OPAL Therapeutics 223

Pique Therapeutics 224

University of Queensland 224

VaxOnco 225

Conclusions 230

Microbial cells 230

Diseased or disease-mimicking cells 230

Dendritic cell vaccines 231

The future of therapeutic vaccines 232

Appendix 233

Primary research methodology 233

Glossary 234

Index 247

References 255

List of FiguresFigure 2.1: Antigen presentation by MHC class I 40

Figure 2.2: Antigen presentation by MHC class II 41

Figure 2.3: ARM treatment of autoimmune disease 46

Figure 3.4: Immunobody activation of T-helper cells 92

Figure 3.5: An example of a Vaccibody 94

Figure 3.6: An Ii Key Hybrid 97

Figure 7.7: Tarmogen vaccination 202

List of TablesTable 2.1: Therapeutic vaccine candidates containing unlinked polypeptide antigens 77

Table 2.2: Therapeutic vaccine candidates containing unlinked polypeptide antigens (ctd 1) 78

Table 2.3: Therapeutic vaccine candidates containing unlinked polypeptide antigens (ctd 2) 79

Table 2.4: Therapeutic vaccine candidates containing unlinked polypeptide antigens (ctd 3) 80

Table 2.5: Therapeutic vaccine candidates containing unlinked polypeptide antigens (ctd 4) 81

Table 2.6: Therapeutic vaccine candidates containing unlinked polypeptide antigens (ctd 5) 82

Table 3.7: Therapeutic vaccine candidates containing peptide antigens linked to polypeptide carriers/adjuvant molecules 117

Table 3.8: Therapeutic
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