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Innovations and Opportunities in Therapeutic Vaccines: Technology Platforms, Key Players, and Early Pipeline Candidates
Date:11/8/2010

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SynCon 155

ProfectusVAX 156

ImuXen 156

Early pipeline vaccine candidates 157

Antigen Express 157

Bayhill Therapeutics 157

CIGB 158

Genetic Immunity 158

Genexine 159

Genovax 159

GeoVax 160

Ichor 161

ImmunoFrontier 162

ImmunoGenetix 162

Immunomic Therapeutics 163

Inovio 164

Karolinska Institute 165

Lipoxen 165

Merck & Co 166

Profectus 167

Scancell 167

University of Miami 168

University of Southampton 169

Vaccibody AS 169

Vical 169

ViroMed 170

Conclusions 173

Chapter 6 Recombinant viruses as vaccines 178

Summary 178

Introduction 179

Technology platforms 179

Alphavaccine 179

MVA-BN 180

Chimpanzee adenovirus vectors 180

Theravax 182

Co-X-Gene 182

ProfectusVAX 182

IBDV 183

Early pipeline vaccine candidates 183

AlphaVax 183

BN ImmunoTherapeutics 184

Crucell 185

Genexine 186

GenPhar 186

GeoVax 186

Okairos 187

Profectus 188

PSMA Development Co 188

Transgene SA 188

TSD Japan 189

Vaxin Inc 190

VectorLogics 190

Virax 191

Conclusions 195

Safety concerns 195

Immunogenicity 196

Chapter 7 Cell-based vaccines 198

Summary 198

Introduction 199

Technology platforms 199

Advaxis' Listeria platform 199

Aduro BioTech's Listeria platforms 200

AEterna Zentaris bacterial carrier system 201

Tarmogens 201

Autologous dendritic cells 203

iAPA 204

DCVax 204

HS System 205

HyperAcute Immunotherapies 206

TGF-? antisense technology 207

ImmuneFx 207

OPALs 209

Early pipeline vaccine candidates 209

Aduro BioTech 209

Advaxis 210

AEterna Zentaris 210

Cadila Pharmaceuticals
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