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Innovations and Opportunities in Therapeutic Vaccines: Technology Platforms, Key Players, and Early Pipeline Candidates



HSP technology 98

ASIT+ 99

CyaA 99

ImmuCcine 100

Kinoid vaccines 100

UBITh 101

Early pipeline vaccine candidates 101

AFFiRiS 101

Antigen Express 102

Antigenics 102

ApoImmune 103

Araclon Biotech 103

Aster Biopharmaceuticals 104

BioTech Tools 104

Braasch Biotech 104

Cancer Research UK 106


Celldex 106

Genticel 107

GSK 108

Immunotech Labs 109

Immunovative Therapies 109

Kancer Ltd 110

Neovacs 110

Pfizer 111

Pro-Cure 112

Recopharma 113

SJ Biomed 113

UBI 114

Vaccibody AS 116

Conclusions 119

Chapter 4 Delivery of peptide antigens using particulate carriers 122

Summary 122

Introduction 123

Technology platforms 123

SupraAntigen 123

ImuXen 124

Lipotek platforms 124

Virosomes 124

Virus-like particles 125

CVLPs 125

HCV VLPs 126

Schiller and Chackerian 126

Auto-antibody drugs 127

Immunodrugs 127

WHcAg VLPs 128

PREPs 128

Versamune 129

CHP Technology 130

DCtag 130

pMHC-NP 131

Cellarium 132

Early pipeline vaccine candidates 132

AC Immune 132

C-Pharma 133

Cytos 134

Dendright 134

Henderson Morely 135

ImmunoFrontier 136

InCytu 137

Lentigen 137

Lipotek 137

Lipoxen 138

Oncothyreon 138

Panvax 139

Parvus Therapeutics 139

PDS Biotech 140

Pevion 141

Select Vaccines 142

VLP Biotech 142

Conclusions 145

Chapter 5 DNA vaccines 148

Summary 148

Introduction 149

Technology platforms 150

Ii suppression 150


ANTIGENeering 151

Peptide-Derivatized Dendrimers 152

IL-12M 153

TriGrid 154

LAMP-vax 154<

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