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Innovations and Opportunities in Therapeutic Vaccines: Technology Platforms, Key Players, and Early Pipeline Candidates
Date:11/8/2010

containing cancer antigens 30

Melacine 31

MVax 32

CreaVax-RCC 32

Oncophage 33

Provenge 33

OncoVAX 35

Conclusions 35

Chapter 2 Vaccines comprising unlinked polypeptide antigens 38

Summary 38

Introduction 39

Technology platforms 41

Polyvalent Vaccines 42

Tolerogenic vaccines 42

Apitopes 43

ToleroMune 44

Tregitopes 44

Complementary peptides 45

Bionor Immuno peptide design 47

TUMAPs 47

magnICON 49

ImmuNovo platforms 49

PepTcell epitope prediction 50

Variosite 51

Optimized cryptic peptides 51

iAPA 52

Early pipeline vaccine candidates 53

ALK-Abello 53

Apitope 54

Axon Neuroscience 55

Bayer Innovation 55

BioArctic Neuroscience 57

Bionor Immuno 57

BioSidus 58

CIGB 58

Circassia 58

CSL 59

CuraVac 59

EpiVax 60

Genovax 60

Green Peptide 61

GSK 62

Helicure 62

iBio 62

Immatics 63

ImmunoCellular Therapeutics 64

Immunotope 65

Immunovaccine 65

ImmunoVentis 66

ImmuNovo 67

Intercell 68

Juvaris 69

MabVax 69

Multimmune 69

OncoTherapy Science 70

Paladin Labs 71

PepTcell 71

Pfizer 71

Profectus 72

PSMA Development Co 73

Shionogi 73

Variation Biotech 73

Vaxine Pty Ltd 74

Vaxon 75

VaxOnco 76

Conclusions 83

Antigenicity 83

Target antigen(s) 83

Tolerance 84

Production 84

Chapter 3 Peptide antigens linked to polypeptide carrier/adjuvant molecules 88

Summary 88

Introduction 89

Technology platforms 89

Haptenization 89

Mimotopes 89

AFFiTOME 90

ADX40 90

ImmunoBodies 91

APC targeting mAb-vaccines 92

Vaccibodies 93

ApoVax 96

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