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Innovations and Opportunities in Therapeutic Vaccines: Technology Platforms, Key Players, and Early Pipeline Candidates
Date:11/8/2010

own benefits and drawbacks, are being used to enhance the delivery of vaccine antigens to target immune cells and to modulate the strength and type of immune responses that result.

Key questions answered

  • What are therapeutic vaccines, and what can they do?
  • Why are so many companies and research institutes working on therapeutic vaccines?
  • Which companies are currently working to validate and develop the latest generation of drug candidates based on therapeutic vaccines?
  • What technological and regulatory challenges face these companies in developing such candidates and bringing them to market?
  • What technologies are being used to design, produce and administer these drug candidates?
  • Who developed these technologies, and who is using them right now?

  • Table of ContentsInnovations and Opportunities in Therapeutic Vaccines

    Executive summary 12

    An introduction to therapeutic vaccines 12

    Vaccines comprising unlinked polypeptide antigens 12

    Peptide antigens linked to polypeptide carrier/adjuvant molecules 14

    Delivery of peptide antigens using particulate carriers 14

    DNA vaccines 15

    Recombinant viruses as vaccines 16

    Cell-based vaccines 17

    Chapter 1 An introduction to therapeutic vaccines 20

    Summary 20

    Introduction 21

    Vaccination 21

    Therapeutic vaccination 22

    Specificity 22

    Potency 23

    Convenience and cost 23

    Challenges for therapeutic vaccines 24

    Disease burden 24

    Immunosuppression 24

    Immuno-avoidance 26

    Examples of therapeutic vaccines already approved for sale/manufacture 27

    Rabies vaccines 27

    Allergy vaccines 27

    Alutard SQ 28

    Grazax 28

    Chanllergen 28

    Multiple sclerosis immunotherapy 29

    BCG vaccines as immunotherapies for cancers 29

    TheraCys 30

    OncoTICE 30

    PACIS 30

    Vaccines
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