Navigation Links
Injection Reverses Heart-Attack Damage
Date:7/23/2009

/p>

When the researchers also stimulated production of a cellular receptor for NRG1, known as ErbB4, cardiomyocyte proliferation was further enhanced, demonstrating that NRG1 works by stimulating this receptor. They also identified the specific kinds of cardiomyocytes (mononucleated) that are most likely to respond to treatment.

In 2007, Kuhn and colleagues first demonstrated that the heart has dormant regenerative capacities that can be reawakened. Kuhn developed a sponge-like patch, soaked in a compound called periostin that is abundant in the developing fetal heart (and in injured skeletal muscle) but scarce in adult hearts. When the patch was placed over the site of cardiac injury in rats, it induced cardiomyocyte proliferation and improved heart function (Nature Medicine 2007; 13:962-9). Similar results were seen in larger animals, and periostin is now in preclinical development at Children's Hospital Boston for future application in human patients with heart failure.

The new work adds a second compound to the heart-regeneration toolbox, and reveals how both periostin and NRG1 work at the cellular and molecular level, an essential step in predicting possible side effects. Both compounds ultimately act on the same cellular pathway, Kuhn found.

"We applied periostin locally at the site of cardiac injury, but NRG1 works when given by systemic injection - a very promising result that suggests it may be feasible to use this in the clinic to treat heart failure," says Kuhn, who won a first prize Young Investigator Award, from the American College of Cardiology in 2007.

The study was funded by the Department of Cardiology at Children's Hospital Boston, the Charles Hood Foundation, and the American Heart Association.

Children's Hospital Boston is home to the world's largest research enterprise
'/>"/>

SOURCE Children's Hospital of Boston
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Phase III Clinical Trial in Newly Diagnosed Multiple Myeloma Stopped Early Due to Highly Significant Efficacy Advantage of VELCADE(R) (Bortezomib) for Injection Based Therapy Across All Endpoints
2. Study Shows Vasopressin Receptor Antagonist VAPRISOL(R) (Conivaptan Hydrochloride Injection) Significantly Increased Serum Sodium Concentration in Patients with Euvolemic & Hypervolemic Hyponatremia
3. Lilly Files for European Approval of ALIMTA(R) (pemetrexed for injection) for First-Line Treatment of Non-Small Cell Lung Cancer
4. Analysis Shows Vernakalant Hydrochloride Injection Increases Conversion to Normal Heart Rhythm in Acute Atrial Fibrillation Patients Treated Within 48 Hours of Onset
5. New Data to Support VELCADE(R) (Bortezomib) For Injection Based Therapies as Setting New Standards in The Care of Newly Diagnosed Patients With Multiple Myeloma
6. Isolagen Inc. Completes Injections of Isolagen Therapy(TM) in Phase III Wrinkle and Phase II Full Face Studies
7. FDA Advisory Committee Supports Efficacy and Safety of Zyprexa(R) Long-Acting Injection (LAI) for Schizophrenia Treatment
8. Millennium Expands VELCADE(R) (Bortezomib) For Injection Program In Non-Hodgkins Lymphoma
9. Inclusion of Six-Year Overall Survival Data in the Eloxatin(R) (oxaliplatin injection) Prescribing Information Granted FDA Priority Review
10. Circulation Publishes Data Showing KYNAPID(TM) (Vernakalant Hydrochloride) Injection Rapidly Converted Short-Duration Atrial Fibrillation to Sinus Rhythm
11. CorMatrix(R) Announces Intramyocardial Injection of Emulsified ECM Technology(TM) Demonstrates Enhanced Angiogenesis and Improved Cardiac Function in a Preclinical Model
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/29/2014)... N.C. , Sept. 29, 2014   ... one of the "Best Places to Work in ... a national leader in the sales and support ... Record solutions for physicians.  TSI Healthcare has over ... the country. The program, sponsored by ...
(Date:9/29/2014)... 2014 Galmed Pharmaceuticals Ltd. (Nasdaq: ... focused on the development and commercialization of a ... diseases and cholesterol gallstones, announced today that it ... Medical Ltd. (TASE: ITMR) ("Itamar Medical"), a publicly-traded ... by the U.S. Food and Drug Administration, or ...
(Date:9/29/2014)... 29, 2014 On Friday, September ... 1.02%, the Dow Jones Industrial Average finished the day ... at 1,982.85, up 0.86%. The gains were broad based ... positive. The S&P 500 Health Care Sector Index ended ... has advanced 1.10% in the last one month. Investor-Edge ...
Breaking Medicine Technology:TSI Healthcare Named One of Modern Healthcare's "Best Places to Work in Healthcare" for Third Consecutive Year 2Galmed Pharmaceuticals and Itamar Medical to Collaborate on Assessing Aramchol's Effect on Endothelial Function 2Galmed Pharmaceuticals and Itamar Medical to Collaborate on Assessing Aramchol's Effect on Endothelial Function 3Pharma Equities Technical Momentum - Provectus Biopharma, Shire, Impax Labs, Zogenix, and TherapeuticsMD 2Pharma Equities Technical Momentum - Provectus Biopharma, Shire, Impax Labs, Zogenix, and TherapeuticsMD 3Pharma Equities Technical Momentum - Provectus Biopharma, Shire, Impax Labs, Zogenix, and TherapeuticsMD 4Pharma Equities Technical Momentum - Provectus Biopharma, Shire, Impax Labs, Zogenix, and TherapeuticsMD 5
... 6, 2011 Endologix, Inc. (Nasdaq: ELGX ... announced today that John McDermott, President and Chief Executive ... of America Merrill Lynch Health Care Conference in Las ... ConferenceDate:Tuesday, May 10, 2011Time:3:40 p.m. PTAn audio Web cast ...
... N.M., May 6, 2011 Qforma, the leading provider of ... health sciences industry, announced today the appointment of Mark Spiers ... President and CEO of Wolters Kluwer Pharma Solutions. ... leader in the pharmaceutical industry, to our Board," said Kelly ...
Cached Medicine Technology:Qforma Appoints New Member to Board of Directors 2
(Date:9/29/2014)... September 30, 2014 NAPW ... Professional, as a 2014 Professional Woman of the ... for leadership in medical device consulting. As the largest, ... spanning virtually every industry and profession, the National Association ... with over 600,000 members and nearly 300 Local Chapters. ...
(Date:9/29/2014)... 30, 2014 NAPW honors ... at Heaven Sent Consultation , as a 2014 ... with this prestigious distinction for leadership in marriage and ... professional women in the country, spanning virtually every industry ... a powerfully vibrant networking community with over 600,000 members ...
(Date:9/29/2014)... NAPW honors Natalie W. ... Private Pediatrics of Palm Beach as a 2014 ... leadership in pediatrics and family care with this prestigious ... the country, spanning virtually every industry and profession, the ... vibrant networking community with over 600,000 members and nearly ...
(Date:9/29/2014)... Park Avenue Dental, a leading ... A. Sherman who has dedicated his career to providing ... announced its inclusion in the Patient Connect 365 dentist ... to private accounts so that they may manage online ... system also allows patients to request appointments, better communicate ...
(Date:9/29/2014)... Denham Springs, LA (PRWEB) September 29, 2014 ... states their mission is to provide students with ... skills and awareness necessary to enhance their own ... Alliance of Fitness Professionals also benefits the community ... research, and service focused on the professional practice ...
Breaking Medicine News(10 mins):Health News:National Association of Professional Women Announces Sandra Lee Bennett, Independent Medical Device Professional, a 2014 Professional Woman of the Year 2Health News:National Association of Professional Women Announces Carmel T. Ross, Marriage and Family Therapist at Heaven Sent Consultation, a 2014 Professional Woman of the Year 2Health News:National Association of Professional Women Announces Dr. Natalie W. Geary, Owner / President of Private Pediatrics of Palm Beach, a 2014 Professional Woman of the Year 2Health News:Florida’s Park Avenue Dental Now Part of Intuitive Patient Connect 365 Dentist Search Portal 2Health News:Florida’s Park Avenue Dental Now Part of Intuitive Patient Connect 365 Dentist Search Portal 3Health News:Narconon Louisiana New Life Retreat Announces Stephen Mogavero Now Certified as a Personal Trainer 2
... may contribute to the development or worsening of ... research abstract that will be presented Tuesday, June ... 25th Anniversary Meeting of the Associated Professional Sleep ... sleep in preschool-age children significantly predicted worse parent-reported ...
... , MONDAY, June 13 (HealthDay News) -- Spending on ... overall and especially among certain groups of patients, a new ... 18 and older who used glaucoma medication between 2001 and ... increased from $445 in 2001 to $557 in 2006. ...
... -- Patient-focused outcomes are emphasized in 10 updated performance ... that were released Monday by a trio of major ... for the use of individual practitioners and group practices ... with hypertension and those with stable coronary disease," Dr. ...
... at Case Western Reserve University School of Medicine have ... that contributes to chronic health problems. If they ... cells called macrophages, "We have a shot at a ... diabetes, heart disease and cancer," said Mukesh K. Jain, ...
... HealthDay Reporter , MONDAY, June 13 (HealthDay News) ... by up to 73 percent, especially when babies are exclusively ... considered the best food for infants, and studies have shown ... for both infants and their mothers. Now, there is more ...
... American Association for Cancer Research is pleased to announce ... families and caregivers won first place in the ... Colon and Rectal Surgeons. Separately, it received three additional ... Society of Professional Journalists. "We are honored ...
Cached Medicine News:Health News:Sleep loss in early childhood may contribute to the development of ADHD symptoms 2Health News:Medical Groups Update Heart, Blood Pressure Care Guidelines 2Health News:Medical Groups Update Heart, Blood Pressure Care Guidelines 3Health News:Genetic factor controls health-harming inflammation in obese 2Health News:Breast-feeding May Shield Against Sudden Infant Death Syndrome 2Health News:Breast-feeding May Shield Against Sudden Infant Death Syndrome 3Health News:AACR's CR magazine honored with 4 prestigious journalism awards 2
... to the National Academy of ... use of cardiac markers in ... is definitive of acute myocardial ... assay was designed for rapid ...
A fluorogenic enzyme-linked immunoassay (ELISA) for the quantitative measurement of myoglobin in human serum or plasma aiding in the diagnosis of acute myocardial infarction (AMI). Features : Dry che...
Clinical marker immunoassay kit for detection of Myoglobin....
AxSYM Myoglobin is a Microparticle Enzyme Immunoassay (MEIA) for the quantitative determination of myoglobin in human serum or plasma on the AxSYM System....
Medicine Products: