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Initial Clinical Data Reveal Potential of Tasimelteon to Reset the Body Clock in Non-24-Hour Sleep-Wake Disorder
Date:1/26/2012

treated with tasimelteon for three months during a run-in phase.  Patients who respond to tasimelteon treatment during the run-in phase, as measured by the resetting and alignment of their body clock to the 24-hour day, will then be randomized either to receive placebo or to continue receiving tasimelteon for 2 months.  During the post-randomization phase, patients will be re-evaluated.  For more information, please visit http://clinicaltrials.gov/.

About Non-24-Hour Disorder

Non-24-Hour Disorder is a chronic circadian rhythm sleep disorder that affects more than 50 percent of the totally blind individuals in the U.S., or 65,000 to 95,000 people.  Non-24-Hour Disorder occurs almost entirely in individuals who are totally blind and lack the light sensitivity necessary to reset the circadian clock.  Without light perception, the brain's circadian rhythms, which guide many of the body's functions, including sleep, are not reset to a regular 24-hour cycle. 

Individuals with Non-24-Hour Disorder are unable to synchronize their internal clock to the 24-hour day-night cycle, which disrupts their sleep-wake cycle.  For more information, please visit http://24sleepwake.com/.

About Tasimelteon

Tasimelteon is the first compound in development for the treatment of Non-24-Hour Disorder.  Tasimelteon is a specific and potent agonist of the human MT1 and MT2 receptors.  Compounds that selectively bind to melatonin receptors are thought to be able to regulate the body clock, which may be useful to treat circadian rhythm disorders.  Tasimelteon is being studied in both Non-24 and Major Depressive Disorder (MDD). 

About Vanda Pharmaceuticals Inc.

Vanda Pharmaceuticals Inc. is a biopharmaceutical company focused on the development and commercialization of produc
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SOURCE Vanda Pharmaceuticals Inc.
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