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Infant Blood May Provide Insights into Diseases Present at Birth
Date:12/15/2008

aid Resau. "Even so, we got good RNA test results from samples that have been in storage for as long as nine years."

While other researchers have confirmed the stability of blood spot RNA and its ability to reflect diseases, VAI researchers are the first to apply the latest tools in RNA technology to measure the expression of genes in blood spots on a larger scale. Using a random sample of blood spots collected from 1998 to 2004, researchers were able to detect an average of 3,480 genes in each sample, and to quantify the levels of several specific genes. Researchers in VAI's Laboratories of Microarray Technology and Molecular Epidemiology led by Resau and lead author of the study, Peterson T. Haak, received valuable assistance and expertise from Nigel Paneth, M.D., and his colleagues at Michigan State University's College of Human Medicine, College of Osteopathic Medicine and Department of Physiology.

"By teaming with state health departments and utilizing existing blood spot archives, we hope to improve our understanding of diseases that are not immediately apparent at birth, but have roots in the perinatal period," said Resau. "Measuring the relative abundance of thousands of expressed genes from

universally collected neonatal blood spots may open new avenues of research into perinatal markers and determinants of disease development."

By state law in effect since 1986, the Michigan Department of Community Health stores blood spots for 21.5 years. Michigan state law explicitly encourages the use of these archived blood spots for medical research; anonymous samples can be obtained for research with approval from an Institutional Review Board and the Michigan Department of Public Health, and individually identified samples can be obtained with parental informed consent.

Established by Jay and Betty Van Andel in 1996, Van Andel Institute is an independent research o
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