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Indevus Pharmaceuticals Announces PRO 2000 Found to Show Promise in Large HIV Prevention Study
Date:2/9/2009

roach for many women who cannot simply rely on condoms or abstinence as methods for protecting themselves from HIV. Even a partially effective microbicide could have a profound impact on the dynamics of HIV transmission. According to mathematical modeling conducted by the London School of Hygiene and Tropical Medicine, 2.5 million HIV infections could be averted over three years if a microbicide with 60 percent effectiveness were used in 73 low-income countries.

About Indevus

Indevus Pharmaceuticals, Inc. is a specialty pharmaceutical company engaged in the acquisition, development, and commercialization of products to treat conditions in urology and endocrinology. The Company's approved products include SANCTURA(R) and SANCTURA XR(TM) for overactive bladder, VANTAS(R) for advanced prostate cancer, SUPPRELIN(R) LA for central precocious puberty, and DELATESTRYL(R) to treat male hypogonadism. The Indevus development pipeline contains multiple compounds within the Company's core therapeutic areas in addition to several partnered or partnerable programs. The most advanced compounds in development include, VALSTAR(TM) for bladder cancer, NEBIDO(R) for hypogonadism, PRO 2000 for the prevention of infection by HIV and other sexually-transmitted pathogens, the octreotide implant for acromegaly and carcinoid syndrome, and pagoclone for stuttering.

PRO 2000

PRO 2000 (a naphthalene sulfonate polymer) is under development as a topical vaginal microbicide to prevent the sexual transmission of HIV and other sexually transmitted diseases. Laboratory studies have shown that PRO 2000 is active against HIV, herpes simplex virus, chlamydia and the bacterium that causes gonorrhea. Vaginally applied PRO 2000 has been found to afford protection in mouse models for genital herpes infection and gonorrhea, and in a simian model for vaginal HIV infection. Prior to initiation of the HPTN 035 trial
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