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Independent Study Published in Clinical Infectious Diseases Highlights the Importance of Antimicrobial Removal Systems in Blood Culture to Rapidly and Accurately Aid in the Diagnosis of Sepsis
Date:2/28/2013

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This independent, hospital-wide study represents the first clinical, head-to-head blood culture comparison study in 15 years. The study focused on the impact of prior antimicrobial exposure on bacterial recovery and time to detection using patient specimens, a key challenge facing critical care physicians and other healthcare professionals in addressing sepsis. The authors found that antibiotic administration prior to blood culture collection was common, with 51 percent of patients in the General Wards receiving antibiotics within four hours prior to blood culture specimen collection. In the medical intensive care unit (MICU), this figure jumped to 82 percent.1

During the eight-month study period, a total of 9,395 blood cultures were collected and evaluated from adult patients admitted into the hospital's in-patient units and emergency departments, resulting in 1,219 (13 percent) positive cultures, of which 831 met the study inclusion criteria.1 Researchers concluded that the BD BACTEC Plus Aerobic medium had statistically significant higher recovery rates when antibiotics had been administered within four hours prior to specimen collection: 91 percent (216/237) of pathogens isolated and a faster time to detection – an average of 4.4 hours faster – as compared to recovery rates of another frequently used aerobic blood culture medium (41 percent or 98/237) evaluated in the study.1 Similar differences in recovery and time to detection in the presence of antibiotics were observed across all time points evaluated.

The study is published in the March 15 issue of Clinical Infectious Diseases and can be viewed online.

About Sepsis
Sepsis is a medical condition characterized by a systemic inflammatory response to infection, contributing to more than 20,000 deaths per day worldwide.2 Globally, an estimated 18 mil
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SOURCE BD-Becton Dickinson
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