Navigation Links
Independent Data Monitoring Committee Recommends Early Stopping of Phase 3 Study of Ibrutinib in Relapsed/Refractory CLL/SLL Patients Based on a Planned Interim Analysis
Date:1/7/2014

ost frequent adverse reaction leading to treatment discontinuation was subdural hematoma (1.8%). Adverse reactions leading to dose reduction occurred in 14% of patients.

Drug Interactions:

CYP3A Inhibitors – Avoid concomitant administration with strong or moderate inhibitors of CYP3A. If a moderate CYP3A inhibitor must be used, reduce the IMBRUVICA dose.

CYP3A Inducers – Avoid co-administration with strong CYP3A inducers.

Special Populations – Hepatic Impairment – Avoid use in patients with baseline hepatic impairment.

For the full prescribing information, visit http://www.imbruvica.com/downloads/Prescribing_Information.pdf

Ibrutinib has been submitted to the European Medicines Agency (EMA) for the treatment of adult patients with relapsed or CLL/SLL or adult patients with relapsed or refractory MCL. Use of ibrutinib in markets and for indications in which it has not been approved is investigational.

Ibrutinib is being jointly developed and commercialized by Janssen and Pharmacyclics, Inc. Pharmacyclics sponsored the study.

For more information, visit www.IMBRUVICA.com.

About Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma
Chronic Lymphocytic Leukemia (CLL) is a slow-growing cancer of the white blood cells (lymphocytes), most commonly B cells. CLL is the most common adult leukemia. Small Lymphocytic Lymphoma (SLL) is a slow-growing lymphoma in which too many immature white blood cells cause lymph nodes to become larger than normal.

About Janssen Research & Development, LLC

At Janssen, we are dedicated to addressing and solving some of the most important unmet medical needs of our time in oncology, immunology, neuroscience, infectious diseases and vaccines, and cardiovascular and metabolic diseases. Driven by our
'/>"/>

SOURCE Janssen Research & Development, LLC
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Hologic Expands its Board of Directors with Appointment of Two Independent Directors and Engages Chairman of Mt. Sinai Radiology Department as Scientific Advisor
2. Actinium Pharmaceuticals Appoints Richard Steinhart As New Independent Director
3. Leica Biosystems Launches Independently* Qualified Menu of IHC Antibodies for Hematopathology
4. American Pacific Board Continues Focus On Corporate Governance With Appointment Of Independent Lead Director
5. Independent Pharmacy Cooperative to Distribute Promescent, Topical Medication for Premature Ejaculation
6. Intarcia Supports American Diabetes Association Call For Independent Review Of Incretin-Based Therapies
7. Boehringer Ingelheim Pharmaceuticals, Inc. and Eli Lilly and Company Statement on the ADA Request for Independent Review of Incretin-Based Therapies
8. Managed Health Care Associates, Inc. (MHA) Released Results of Sixth Annual Independent Long Term Care Member Study with Expanded Specialty Pharmacy Findings
9. Agnitio Launches Rainmaker One to Remove the Complexity of Managing Independent Apps
10. Independent Drugstore Lobby Wants Sweeping Antitrust Exemptions to Charge Higher Prescription Drug Prices
11. Independent Study Published in Clinical Infectious Diseases Highlights the Importance of Antimicrobial Removal Systems in Blood Culture to Rapidly and Accurately Aid in the Diagnosis of Sepsis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... -- In recognition of the increased risks that seniors ... pneumonia, shingles and other illnesses, CVS/pharmacy ® ... be Senior Vaccination Month. Because people,s immune systems ... adults ages 65 years and older stay up ... MinuteClinic nurse practitioners and physician assistants will be ...
(Date:8/28/2014)...  Stryker Orthopaedics, the Official Joint Replacement Products of the ... joint health to golf fans at the next stop of ... Championship. The company,s fan destination – "The Stryker Mobility Zone" ... at the TPC Boston in Norton, MA ... At the Deutsche Bank Championship, Stryker will be providing ...
(Date:8/28/2014)... Aug. 28, 2014  Critical Process Filtration, Inc. ... today announces the expansion of their Technical Services ... Filtration now offers customers and potential customers services ... filter failure analyses (even for competitor filters) and ... hallmark services of system benchmarking and cost/performance optimization. ...
Breaking Medicine Technology:September is Senior Vaccination Month at CVS/pharmacy and MinuteClinic 2September is Senior Vaccination Month at CVS/pharmacy and MinuteClinic 3September is Senior Vaccination Month at CVS/pharmacy and MinuteClinic 4Stryker, Official Joint Replacement Products Of The PGA TOUR, Heads To Boston For The Deutsche Bank Championship 2Stryker, Official Joint Replacement Products Of The PGA TOUR, Heads To Boston For The Deutsche Bank Championship 3Stryker, Official Joint Replacement Products Of The PGA TOUR, Heads To Boston For The Deutsche Bank Championship 4Stryker, Official Joint Replacement Products Of The PGA TOUR, Heads To Boston For The Deutsche Bank Championship 5Critical Process Filtration, Inc. Announces Expanded Technical Services and Validation Support 2
(Date:8/28/2014)... Ariz. (PRWEB) August 28, 2014 Arizona ... Force Impact Technologies , has been named one of ... the Year competition. , This is the fourth consecutive ... in the competition. Jared Schoepf, co-founder of SafeSIPP, and ... 2013 and 2012, respectively. In 2011, ASU dominated the ...
(Date:8/28/2014)... Reinberg HealthDay Reporter THURSDAY, ... the diet may worsen symptoms of multiple sclerosis (MS), a ... MS, such as vitamin D, smoking and Epstein Barr virus ... another environmental factor affecting MS patients," said lead researcher Dr. ... in Buenos Aires. Multiple sclerosis is a disease of ...
(Date:8/28/2014)... and Ann Arbor, MI (PRWEB) August 28, 2014 ... company and the nation’s leading intraoperative neurophysiology monitoring ("IONM") ... and CFO, to the position of Chief Executive Officer ... CFO, was promoted to President and CFO in 2013 ... growth and success. , “Bill’s efforts and achievements ...
(Date:8/28/2014)... Mount Vernon, Ind. (PRWEB) August 28, 2014 ... subsidiary of Valero Energy Corporation (NYSE: VLO), and the ... other state and local officials today at a Port ... recently purchased Mount Vernon ethanol plant. , “The opening ... Indiana-Mount Vernon is another economic development win for ...
(Date:8/28/2014)... Norton HealthDay Reporter THURSDAY, ... sending electrical currents through the scalp to a specific network ... a day. In a small study of healthy young ... certain networks involved in memory. That, in turn, boosted participants, ... after the brain stimulation. During TMS, an electromagnetic coil ...
Breaking Medicine News(10 mins):Health News:Arizona State University Grad Student in the Running for College Entrepreneur of the Year 2Health News:Arizona State University Grad Student in the Running for College Entrepreneur of the Year 3Health News:Could Too Much Salt Harm MS Patients? 2Health News:Could Too Much Salt Harm MS Patients? 3Health News:Biotronic NeuroNetwork Announces the Promotion of Bill Gecsey to CEO 2Health News:Valero, Ports of Indiana Celebrate Restart of Ethanol Plant 2Health News:Valero, Ports of Indiana Celebrate Restart of Ethanol Plant 3Health News:Electrical Pulses to Scalp May Boost Memory: Study 2Health News:Electrical Pulses to Scalp May Boost Memory: Study 3
... treated for Hodgkin disease are at an increased risk ... heart attacks// associated with different types of treatment, and ... least 25 years after Hodgkin disease treatment. ... causes enlargement of lymph nodes, spleen, or other immune ...
... Clinical Pediatrics, it is reported that breast feeding mothers may ... care of, their children// may not be affected by vitamin ... team belonging to University of Michigan conducted a study among ... Twenty of the mothers were found to be deficient in ...
... spend Rs.30 million per annum for the treatment of cancer ... - over four times the amount it spends at present. ... (2007-08). ,"The existing fund of Rs.7 million ... insufficient. So it will be increased to Rs.30 million from ...
... that contain high levels of action, such as Unreal Tournament, ... University of Rochester have shown that people who played action ... course of a month improved by about 20% in their ... similar to ones used in regular ophthalmology clinics. ...
... the February issue of Archives of General Psychiatry, one ... as// fatigue and loss of appetite—may be associated with ... coronary artery disease. ,Considerable evidence suggests that ... the risk for coronary artery disease, which occurs when ...
... recent Analysis of the survey data from 55 developing countries ... from the rest of society.// ,It was ... have risen over several decades, but it was not clear ... ,In this research published in the latest issue of ...
Cached Medicine News:Health News:Researchers Analyzes Risk Between Hodgkin Disease and Heart Attack Mortality 2Health News:Funds Increased for Treating Bhopal Gas Victims 2Health News:Action Video Games Improves Vision 2Health News:Symptoms of Depression Associated With Artery Diseases 2
... Bulb Direct has been ... Internet since 1996, and we ... 100% satisfaction guarantee. Check out ... and see our discount light ...
... been selling replacement bulbs on ... we are extremely proud of ... out our catalog of replacement ... light bulbs specials. ,Check ...
... Bulb Direct has been selling ... since 1996, and we are ... satisfaction guarantee. Check out our ... see our discount light bulbs ...
... Bulb Direct has been ... Internet since 1996, and we ... 100% satisfaction guarantee. Check out ... and see our discount light ...
Medicine Products: