Navigation Links
Independent Analyses of the SEAS, SHARP and IMPROVE-IT Studies of Ezetimibe
Date:7/21/2008

>

Two other large trials of ezetimibe + statin are still in progress: (i) SHARP (ezetimibe + simvastatin vs placebo in 9,000 patients; recruitment completed, but treatment and follow-up continuing) and (ii) IMPROVE-IT (ezetimibe + simvastatin vs placebo + simvastatin in 11,000 patients; recruitment continues towards an eventual target of 18,000 patients). Together, they have already accumulated about four times as many cancers as SEAS (see table). If treatment really did increase total cancer by 50% then this would have been clearly apparent in the hypothesis testing SHARP & IMPROVE-IT trials. Instead, there was no evidence of any increase in cancer (see table).

Cancer events Active Control

Hypothesis generator: SEAS 102 67

Hypothesis test: SHARP & IMPROVE-IT* 313 326

* 216 active vs 254 control non-fatal cases and 97 vs 72 fatal cases.

If there were a real adverse effect on cancer incidence or cancer mortality then previous experience with the epidemiology of cancer (ie, with other causes of the disease in humans) strongly suggests that the relative risk (active versus control) should grow bigger with time, but it does not, whether the hypothesis-testing trials are considered separately or all 3 trials are considered together.

Note: The University of Oxford Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU) has decades of experience in cancer epidemiology, in vascular and other trials, and in collaborative meta-analyses of trials. Although CTSU is conducting the SHARP trial, it is doing so independently of the source of funding, and has a policy of not accepting honoraria or consultancy fees. This report to regulatory authorities on the analyses of SEAS, SHARP and IMPROVE-IT was initiated, conducted and interpreted by the CTSU independently of any source of funding.

For more information, please, refer to the press release issued by the SEAS
'/>"/>

SOURCE ;
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Video: New Research Discovers Independent Brain Networks Control Human Walking
2. Facet Solutions AFRS(TM) Demonstrates Biomechanical Advantages Over Dynamic Stabilization in Independent Testing
3. Independent Clinical Results Confirm Up to a 7-Centimeter Reduction in Body Circumference Using UltraShape(TM) Non-Invasive Fat Reduction and Body Contouring System
4. Independent Physician Surveys Show if Approved, MF101 Could Become First-Line Treatment for Menopause Symptoms
5. Independent Data Safety Monitoring Board Recommends Continuation of Sangarts Pivotal Phase III Trials of Hemospan(R) Following Second Interim Review
6. Longevinex(R) Found to be Superior to Green Tea Molecule in Independent Human Study
7. Independent Studies Report on Possible Roles for Cylexs Immune Cell Function Assay in Monitoring of Heart and Lung Transplant Recipients
8. Seven Presentations by Two Independent Research Groups Highlight Advantages of Pressure Cycling Technology (PCT) at Scientific Symposia in Philadelphia, Boston, and New York City
9. Video: Major Independent Trial Demonstrates Significant Anticancer Benefit of Zometa(R) in Women With Early-Stage Breast Cancer
10. Promise of Vicals CMV Vaccine Noted by Independent Experts
11. ASPIRE Independent Review Board Announces 10 Ways to Protect Participants Rights in Clinical Drug Trials and Optimize Results From Research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2015)... , July 27, 2015 As ... "Bionics Market - Global Industry Analysis, Size, Share, Growth, Trends ... at USD 7.96 billion in 2014, growing at a CAGR ... 20.49 billion in 2021. The global bionics market ... of accidents, which is leading to paralysis or amputation of ...
(Date:7/27/2015)... -- Research and Markets ( http://www.researchandmarkets.com/research/t63pbj/medical_device ) has announced ... Asia/Pacific Markets Seminar" conference to their offering. ... is well established, the next growth area is ... together with other countries in this region have all ... own medical device regulations. This seminar will provide a ...
(Date:7/27/2015)... 17, 2015 Research and Markets ( ... "G-Protein Coupled Receptors Market: Global Industry Analysis, ... 2022" report to their offering. ... based on of assay type, therapeutic area, and ... has been categorized into six major segments: cAMP ...
Breaking Medicine Technology:Global Bionics Market is Expected to Reach USD 20.49 Billion in 2021, Growing at CAGR of 13.2% From 2015 to 2021: Transparency Market Research 2Global Bionics Market is Expected to Reach USD 20.49 Billion in 2021, Growing at CAGR of 13.2% From 2015 to 2021: Transparency Market Research 3Global Bionics Market is Expected to Reach USD 20.49 Billion in 2021, Growing at CAGR of 13.2% From 2015 to 2021: Transparency Market Research 4Medical Device Regulation in Asia/Pacific Markets Seminar: London, UK - 21st, 22nd of September 2015 2G-Protein Coupled Receptors Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2022 2
(Date:7/28/2015)... Florida (PRWEB) , ... July 28, 2015 , ... ... America's trusted source for identifying Top Doctors, has based its selection process on ... the most outstanding in their medical specialties, in any area of medicine and ...
(Date:7/28/2015)... ... July 28, 2015 , ... Maryland Brain & Spine has ... along with it, more service offerings, updated treatment techniques, and additional state-of-the art online ... management and minimally invasive surgical treatment of brain and spine conditions. , “Adding ...
(Date:7/28/2015)... , ... July 28, 2015 , ... Advanced Fertility ... organization’s inception in 2010, and Dr Dozortsev , a Reproductive Laboratory Director ... president. In 2012, he was succeeded by Dr Gianpiero Palermo, who is credited with ...
(Date:7/28/2015)... ... July 28, 2015 , ... The joint SCAN ... such as reducing high-risk medication use and improving compliance with diabetes treatment guidelines. ... behaviors and outcomes, this unique-in-the-industry Quality Network Program may be paving the way ...
(Date:7/28/2015)... ... 28, 2015 , ... American Sentinel University has been named ... for Geisinger Health System (GHS), one of the nation’s largest integrated health services ... with access to American Sentinel’s affordable, flexible and CCNE-accredited RN to BSN nursing ...
Breaking Medicine News(10 mins):Health News:Fort Myers Plastic Surgeon Recognized as One of the America’s “Top Doctors®” by Prestigious Castle Connolly Medical Ltd. for 5 Years in a Row 2Health News:Fort Myers Plastic Surgeon Recognized as One of the America’s “Top Doctors®” by Prestigious Castle Connolly Medical Ltd. for 5 Years in a Row 3Health News:Maryland Brain & Spine Announces New Specialty, New Name 2Health News:Maryland Brain & Spine Announces New Specialty, New Name 3Health News:Maryland Brain & Spine Announces New Specialty, New Name 4Health News:Advanced Fertility Center of Texas Is Proud to Announce That Our Lab Director Has Been Re-elected as The American College of Embryology President 2Health News:SCAN/Express Scripts MA Pharmacy Quality Network Program to be Featured in Upcoming AIS Webinar 2Health News:SCAN/Express Scripts MA Pharmacy Quality Network Program to be Featured in Upcoming AIS Webinar 3Health News:American Sentinel University Selected to Provide Online RN to BSN Cohorts to Geisinger Health System 2Health News:American Sentinel University Selected to Provide Online RN to BSN Cohorts to Geisinger Health System 3Health News:American Sentinel University Selected to Provide Online RN to BSN Cohorts to Geisinger Health System 4
... Novel protocol could provide new lung tissue for certain ... -- Belgian scientists who used embryonic stem cells to ... alternative to lung transplants for patients with chronic obstructive ... is the first time it,s been shown that embryonic ...
... ... BWIN™, and WaveRider® Product Lines , ... (PRWEB) November 6, 2009 -- WAV, Inc., the ... it has partnered with Vecima Networks Inc. (TSX:VCM), a leading provider of equipment ...
... of protests and arrests. , WASHINGTON, Nov. 6 ... Pelosi,s office for tearing up the "Health Care" bill. They ... and William Kee. , Hearing to be held at ... P.M., Friday, November 6, these five pro-life advocates will appear ...
... , PHILADELPHIA, Nov. 6 In a newly-published special ... hospital policies to prevent and treat venous thromboembolism (VTE), ... throughout the world. Lippincott Williams & Wilkins ... VTE, a disease that includes both the common medical ...
... Congressman Fattah releases the following statement in observance of Pancreatic ... is a rare and perplexing disease, yet it is the fourth ... year, more than 42,000 Americans will be diagnosed with the disease ... far too high. , "To find a cure for pancreatic ...
... role in boosting memories -- or forgetting them, researchers say ... remember the first time you smelled a type of flower? ... brain might. , In the study, published online Nov. ... objects to adult study participants. They paired the objects with ...
Cached Medicine News:Health News:WAV Distribution Partners with Vecima Networks Inc. 2Health News:WAV Distribution Partners with Vecima Networks Inc. 3Health News:Journal of Cardiovascular Nursing Urges Policies and Prevention To Reduce Deaths from Venous Thromboembolism 2Health News:Journal of Cardiovascular Nursing Urges Policies and Prevention To Reduce Deaths from Venous Thromboembolism 3Health News:New Smells 'Etched' in Brain: Study 2
... enzymatic cleaner is a fast-acting ... stubborn deposits in as little ... enzymatic cleaner contains an enzyme ... film on soft contact lenses ...
... These specialty Eraser instruments have been ... with the right tool for situations ... a series of 25 gauge intraocular, ... discrete treatment of target tissues for ...
Wet-Field Hemostatic Eraser bipolar tip, packsize is 10/box....
Sterile cordless eraser tips, packsize is 10/box....
Medicine Products: