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Incidence of Gastrointestinal Disorders in Patients With Parkinson's Disease Increased Over Time and Impacted Clinical and Health Economic Outcomes
Date:6/14/2011

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  • 50% for patients younger than 65 years of age
  • 68% for patients between 65 and 75 years of age
  • 72% for patients older than 75 years of age

  • PD patients with prior GID diagnosis experienced higher incidences of the following, according to a subset analysis

    • Dysfunctions of the neuropsychiatric, autonomic and sensory systems
      • Depression – 1.23-fold higher in PD patients with GIDs (p=0.0347)
      • Anxiety – 1.61-fold higher in PD patients with GIDs (p=0.0062)
      • Psychosexual dysfunction – 8.00-fold higher in PD patients with GIDs (p=0.0499)
      • Ataxia – 1.24-fold higher in PD patients with GIDs (p=0.0286)
      • Pain – 1.29-fold higher in PD patients with GIDs (p=0.0003)
    • Motor, urogenital, and cardiovascular disturbances
      • Movement disorders – 1.39-fold higher in PD patients with GIDs (p=0.0053)
      • Urinary incontinence – 1.43-fold higher in PD patients with GIDs (p=0.0156)
      • Falls – 1.44-fold higher in PD patients with GIDs (p=0.0356)
    • Increased healthcare utilization and costs
    • ER visits – 1.42-fold higher in PD patients with GIDs (p=0.0011)
    • Drugs prescribed for pain, sleep disorders or depression – 1.06-fold higher in PD patients with GIDs (p=0.0432)
    • PD-related healthcare costs – 1.13-fold higher in PD patients with GIDs (p=0.0038)
    • Non-PD-related healthcare costs – 1.12-fold higher in PD patients with GIDs (p=0.0088)

    About the Study

    The objectives of this retrospective observational study were to examine the incidence of GID in PD patients in a US population, and to examine subsequent PD-related outcomes in patients with GIDs.  Findings came from a U.S. health claims database* of patients
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    SOURCE UCB
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