Navigation Links
Inability of Pixantrone to Form Toxic Iron Complexes Results in Significant Reduction in Cardiac Cell Toxicity Compared to Currently Marketed Anthracyclines
Date:12/8/2009

eristic of the drug to iron complex formation, confirming the expected 1:3 Fe(II)-drug ratio for both doxorubicin and mitoxantrone. In contrast, no spectrophotometric changes were observed with iron added to pixantrone, clearly demonstrating that pixantrone does not bind iron. In vitro studies using H2C9 rat myocardial cells indicate that pixantrone (ID50 >50 ug/ml) is far less toxic than doxorubicin (ID50= 1 ug/ml). Moreover, pixantrone does not induce significant reactive oxygen species (ROS) production in the H2C9 cells compared to doxorubicin.

About Pixantrone

Pixantrone (BBR 2778), is a novel topoisomerase II inhibitor with an aza-anthracenedione molecular structure that differentiates it from the anthracyclines and other related chemotherapy agents. Anthracyclines are the cornerstone therapeutic for the treatment of lymphoma, leukemia, and breast cancer. Although they are sufficiently effective to be used as first-line (initial) treatment, they cause cumulative heart damage that may result in congestive heart failure many years later. As a result, there is a lifetime limit of anthracycline doses and most patients who previously have been treated with an anthracycline are not able to receive further anthracycline treatment if their disease returns. It also can be administered through a peripheral vein rather than a central implanted catheter as required for other drugs in this class. Pixantrone has been granted fast track status designation.

About Cell Therapeutics, Inc.

Headquartered in Seattle, CTI is a biopharmaceutical company committed to developing an integrated portfolio of oncology products aimed at making cancer more treatable. For additional information, please visit www.CellTherapeutics.com.

Sign up for email alerts and get RSS feeds at our Web site, '/>"/>

SOURCE Cell Therapeutics, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. BD Ranked in the Top 100 Greenest Big Companies by Newsweek; Named Again to Dow Jones Sustainability World and North America Indexes
2. US Oncology, Inc. to Exhibit iKnowMed(TM) at the 2009 ASCO EHR Symposium: Harnessing the EHR: From Incentives to Sustainability
3. 18 month Follow-up Data on Phase III Study of Pixantrone in Late Stage Relapsed or Refractory, Aggressive Non-Hodgkins Lymphoma Continues to Demonstrate Significant Improvement in Complete Remission and Progression Free Survival Over Standard Chemotherap
4. FDA Sets Action Date of April 23, 2010 for Review of Pixantrone NDA
5. Responses After Completion of Therapy Increase Pixantrone Complete Remission (CR)/Unconfirmed Complete Remission (CRu) Rate to 24% and Overall Response Rate (ORR) to 40% Compared to 7% and 14% for Comparator Agents in Phase III EXTEND Trial in 3rd Line Th
6. Overview of Pixantrone Phase III Clinical Data Presentation at American Society of Clinical Oncology 2009 Annual Meeting Now Available at Clinical Care Options
7. Pixantrone in Combination with Chemotherapy Regimens Produces Overall Response Rates of 58-74% with Complete Remission Rates of 37-57% in Relapsed/Refractory Aggressive or Indolent NHL
8. Pixantrone Produces High Rates of Complete and Partial Remissions Even Among Aggressive NHL Patients With Extensive Prior Doxorubicin Treatment or Prior Rituximab Treatment
9. Pixantrone Phase 3 Data to be Presented at the 2009 American Society of Clinical Oncology (ASCO) Annual Meeting
10. Compared to Standard Therapies, Pixantrone Decreases Time to Achieve Complete Remission by 47% in Relapsed Aggressive Non-Hodgkins Lymphoma
11. Cell Therapeutics and IDIS Announce Agreement for a European Named Patient/Compassionate Use Program for Pixantrone
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2015)... 2015 Harwood Feffer LLP ( www.hfesq.com ) ... of Aerie Pharmaceuticals, Inc. ("Aerie" or the "Company") (NASDAQ: ... its fiduciary duties to shareholders. On April ... results from its first Phase 3 registration trial of ... in the trial, Rhopressa failed to meet its primary ...
(Date:4/27/2015)... -- Research and Markets ( http://www.researchandmarkets.com/research/t2mvbz/endoscopy_global ... "Endoscopy Global Market - Forecast to 2020" ... http://photos.prnewswire.com/prnh/20130307/600769) , , ,The global endoscopy market is ... growing at around 7.0% CAGR from 2014 to ... are aging population, increase in cancer, diabetes, and ...
(Date:4/27/2015)... April 27, 2015 Vermillion, Inc. ... gynecologic disease, announced today it will report ... market close on Monday, May 11, 2015, ... webcast at 4:30pm Eastern.Conference Call & Webcast: ... Pacific Domestic: , 888-556-4997International: , 719-457-2628Conference ID: ...
Breaking Medicine Technology:Harwood Feffer LLP Announces Investigation of Aerie Pharmaceuticals, Inc. 2Endoscopy Global Market - Forecast to 2020: Market is expected to reach approximately $43 billion with Johnson and Johnson, Olympus and Covidien Dominating 2Endoscopy Global Market - Forecast to 2020: Market is expected to reach approximately $43 billion with Johnson and Johnson, Olympus and Covidien Dominating 3
... Va., Nov. 10, 2011 Primary healthcare distributors continue ... navigating economic, regulatory and business climate challenges in the ... in the U.S. Healthcare Industry released by the ... the non-profit research foundation of the Healthcare Distribution Management ...
... SKILLMAN, N.J., Nov. 10, 2011 ConvaTec Healthcare today announced that ... 15, 2011. David Johnson, CEO and George Kegler, CFO will host ... telephone. Questions and answers will follow. To participate ... 701-0354. To participate in the conference internationally, dial ...
Cached Medicine Technology:Pharmaceutical Distributors Continue to Deliver Operational Efficiencies and Value to U.S. Healthcare System Amidst Economic and Regulatory Challenges 2Pharmaceutical Distributors Continue to Deliver Operational Efficiencies and Value to U.S. Healthcare System Amidst Economic and Regulatory Challenges 3Pharmaceutical Distributors Continue to Deliver Operational Efficiencies and Value to U.S. Healthcare System Amidst Economic and Regulatory Challenges 4ConvaTec Healthcare Announces 2011 Third Quarter Earnings Call 2
(Date:4/27/2015)... MN (PRWEB) April 27, 2015 Based ... Secura Consultants is one of the few insurance marketing ... in the income and asset protection markets as well ... the industry has afforded Secura Consultants the opportunity to ... to make doing business easier and quicker. , An ...
(Date:4/27/2015)... (PRWEB) April 27, 2015 According to ... and Craniofacial Research), after chronic back pain, TMJ disorders ... resulting in pain and disability. In addition, the report ... percent of the population, costing an estimated 4 billion ... million Americans suffering from seemingly unrelated symptoms such as ...
(Date:4/27/2015)... 2015 The Doctors on Liens ... of personal injury attorneys with the best doctors working on ... steady growth throughout their history and that trend continues with ... and his team in the Tujunga / Sunland ... massage therapist, patients can find comprehensive care and detailed documentation ...
(Date:4/27/2015)... 2015 TayganPoint Consulting Group, a ... announce their sponsorship of Girls on the Run ... on the Run is a youth development program ... The program is delivered through an interactive curriculum ... to develop the whole girl – physically, mentally, ...
(Date:4/27/2015)... New York, NY (PRWEB) April 27, 2015 ... Jimmy Buffett tickets at the Alpine Valley Music ... in the Elkhart, Wisconsin and Albuquerque, New Mexico area ... in their neck of the woods. Buffett will ... News in Wisconsin. His tour stops during the ...
Breaking Medicine News(10 mins):Health News:Simplified Solutions Now Makes Disability Insurance Business With Secura Consultants Even Easier! 2Health News:Dentist in Graham NC Reveals that a Jaw Disorder May Be the Cause of Chronic Headaches and Back Pain 2Health News:Prominent Doctors with Distinguished Backgrounds Join Doctors on Liens in Tujunga 2Health News:TayganPoint Consulting Group Announces Sponsorship of Girls on the Run 2Health News:Cheap Jimmy Buffett Tickets at Alpine Valley Music Theatre in Elkhorn, WI and at Isleta Amphitheater in Albuquerque, NM Now on Sale at TicketDown.com 2
... and format for its “OneMedForum 2009” finance ... in San Francisco at the Sir Francis ... and disrupters” affecting each of the following ... System and Neurostimulation; Cardiology; Urology and Sexual ...
... Farms, Inc.,(OTC Bulletin Board: USFM), a diversified commercial ... Network (OTCFN), a division of,National Financial Communications Corp. ... The OTCFN Report details US Farms, Inc.,s current ... growth and,management team. Interested parties can download ...
... Genaera Corporation (Nasdaq: GENR ) today announced ... to present at the 2008 RBC Capital Markets Healthcare Conference. ... discussion of obesity, entitled, "Shrinking The Obesity Epidemic," and will ... York on Wednesday, December 11 at 11:00 a.m. ET. , ...
... WASHINGTON, Dec. 4 Stem cells derived from bone marrow ... disease called epidermolysis bullosa (EB), a disorder characterized by extraordinarily ... Blood , the official journal of the American Society of ... bullosa is a disorder characterized by extraordinarily fragile skin and ...
... the Nation in Giving as Demand for Nonprofit Services Peaks ... More than half of Coloradans report that they will ... during the economic downturn, according to " Generous Colorado: Why ... which reflects data from surveys conducted October 2008. With demand ...
... Empowerment Fund by purchasing the Green Bracelet at www.simmonsjewelryco.com , ... The Diamond Empowerment Fund (D.E.F.), Hearst Magazines, and ... exclusive "Empowerment for Africa" dinner held at Hearst Tower in ... co-founder Russell Simmons and special guests including ...
Cached Medicine News:Health News: OneMedPlace announces panels for "OneMedForum 2009: Disrupters and Drivers in Eight Areas of Medical Technology" -- CEOs and investors to meet in unique format of focused sessions 2Health News:OTC Financial Network Issues Corporate Profile on US Farms, Inc. 2Health News:OTC Financial Network Issues Corporate Profile on US Farms, Inc. 3Health News:Genaera to Participate in Obesity Panel at RBC Capital Markets Healthcare Conference 2Health News:Bone Marrow-Derived Stem Cells May Offer Novel Therapeutic Option for Skin Disorder 2Health News:Bone Marrow-Derived Stem Cells May Offer Novel Therapeutic Option for Skin Disorder 3Health News:Bone Marrow-Derived Stem Cells May Offer Novel Therapeutic Option for Skin Disorder 4Health News:Economy Doesn't Dampen Colorado's Giving Spirit According to Statewide Giving and Volunteering Study 2Health News:Economy Doesn't Dampen Colorado's Giving Spirit According to Statewide Giving and Volunteering Study 3Health News:Economy Doesn't Dampen Colorado's Giving Spirit According to Statewide Giving and Volunteering Study 4Health News:On World AIDS Day, Russell Simmons and Special Guests Attended 'Empowerment for Africa' Dinner 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: