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In Vivo Data on Taligen Therapeutics' Pipeline Candidates Presented at the XXII International Complement Workshop
Date:10/7/2008

er confirmation to the therapeutic potential of targeting the alternative pathway in complement-mediated diseases, the study showed intravenous administration of TT30 could specifically target a site of complement activation and be an effective alternative to intraocular injections.

Growing pipeline

Additional In vivo data were presented for CR2-Crry, a previously undisclosed Taligen pipeline candidate. CR2-Crry is a fusion protein combining CR2 with Crry, a murine analogue of human complement receptor 1 (CR1), which appears to inhibit all three complement pathways. Atkinson et al. showed in a myocardial ischemia/reperfusion injury study (Poster #196) that single doses of CR2-Crry and TT30 were equivalent in protecting heart grafts from ischemia/reperfusion injury. However, when both compounds were tested for their effectiveness in preventing antibody-mediated graft rejection, multiple doses of CR2-Crry were superior to TT30 in increasing graft survival. The study showed the critical importance of the alternative complement pathway in ischemia-reperfusion injury but also highlighted the role of the classical and lectin pathways in antibody-mediated rejection.

About Taligen Therapeutics

Taligen Therapeutics is focused on the discovery and development of novel protein therapeutics that are designed to modulate the alternative pathway of the complement system to treat a wide range of inflammatory conditions and diseases. The Company's lead therapeutic candidates are monoclonal antibodies and recombinant fusion proteins that target key factors in the alternative pathway, which Taligen's founders have validated as an important amplification loop in the inflammation process. Taligen's headquarters and late-stage research and development operations are located in Cambridge, Mass. The company also maintains a drug discovery operation in Denver that is closely aligned with an international complement biology research network organized by Michael H
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