Navigation Links
In Vivo Data on Taligen Therapeutics' Pipeline Candidates Presented at the XXII International Complement Workshop
Date:10/7/2008

udies in models for several complement-mediated diseases showed that targeted inhibition of the alternative complement pathway slowed or halted disease progression in these models. Sekine et al. investigated whether TT30 prevented progression of renal disease in a lupus nephritis murine model (Poster #174). TT30 is a fusion protein coupling domains from complement receptor 2 (CR2) with the alternative pathway inhibitor factor H (fH). Treatment with the CR2 domain alone led to decreases in autoantibodies, while treatment with TT30 resulted in additional beneficial effects including significantly reduced renal injury, proteinuria and anti-dsDNA antibody levels compared to controls. Therefore, the dual action of TT30 (CR2 and fH) prevented disease progression in this animal model.

Thurman et al. (Poster #171) compared the effect of systemic administration of TT30 to the effect of CR2-Crry in an airway hyper-responsiveness asthma animal model. CR2-Crry is an inhibitor of the alternative, classical and lectin complement pathways whereas TT30 inhibits only the alternative pathway. The study showed that both TT30 and CR2-Crry significantly reduced airway hyper-responsiveness. This suggests that targeting the alternative complement pathway, while keeping the classical and lectin complement pathways unaffected, may be sufficient to control complement-mediated diseases and thus reduce the risk of infection.

Wet AMD animal model study suggests an alternative to intraocular drug administration

Currently marketed therapies for wet AMD require intraocular injections. In a wet AMD animal model, Rohrer et al. (Poster #202) tested whether TT30 could be effective in preventing progression of choroidal neovascularization following argon laser photocoagulation if TT30 was injected intraocularly or intravenously. The Rohrer team demonstrated that TT30 prevented progression of choroidal neovascularization regardless of the mode of administration. Besides adding furth
'/>"/>

SOURCE Taligen Therapeutics Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Data from In Vivo Disease Models on Taligen Therapeutics Pipeline Candidates to be Presented at the XXII International Complement Workshop
2. Taligen Therapeutics Initiates Corporate Growth Plan with Appointment of Abbie Celniker, Ph.D., as CEO and Establishment of Cambridge, Mass., Headquarters
3. BN ImmunoTherapeutics Announces Positive Mature Phase II Results From Newly Acquired Prostate Cancer Vaccine
4. Video: Sirion Therapeutics Launches Durezol for Postoperative Ocular Inflammation and Pain
5. Orexigen(R) Therapeutics Presents Data on Its Proprietary Formulation of Naltrexone Sustained Release (SR) Used in Contrave(R)
6. PTC Therapeutics Announces Data Showing Six-Minute Walk Test Consistently Measures Ambulatory Function in Patients With Duchenne Muscular Dystrophy
7. Data Confirm Synvista Therapeutics Haptoglobin Diagnostic Test Kit Success in Rapidly Determining Cardiovascular Risk in Patients with Diabetes
8. Logical Therapeutics Inc. Commences Double-Blind, Randomized Study of Their Lead Program, LT-NS001
9. Agile Therapeutics Achieves Phase 2 Study Endpoints in Key Clinical Trials with New, Innovative Low-Dose Contraceptive Patch
10. Tobira Therapeutics Inc. Receives US Patent for TBR-652
11. MabVax Therapeutics Closes Two Licensing Agreements With Sloan-Kettering Institute for Cancer Research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... , July 31, 2014  Cannabis Science, ... cannabis formulation-based drug development and related consulting, is ... of multiple strains of cannabis and European Union ... select the best strains for development of proprietary ... cannabis formulations to market for critical ailments such ...
(Date:7/31/2014)... , July 31, 2014 genae, a ... industries, announced today the incorporation of genae UK in ... has one of the largest medical device markets in the ... it is projected to increase by a CAGR of 6.0% until ... equal to 9.5% of GDP. Despite recessionary pressures, market growth rates ...
(Date:7/31/2014)... July 31, 2014 Astellas has appointed ... corporate and employee communications in the Americas region. ... , senior vice president, chief communications officer. In ... and leading corporate brand initiatives and reputation management ... and South America . She ...
Breaking Medicine Technology:Cannabis Science Initiates Scientific Cultivation Programs to Test Multiple Strains of Cannabis to Obtain Extract Formulations for Clinical Drug Development Targeting Multiple Critical Ailments Starting with Cancer and Neurological Disorders 2genae Opens Offices in London 2Astellas Hires Industry Veteran Moyra Knight as Head of Corporate and Employee Communications 2
... 16, 2011 Reportlinker.com announces that a new ... US Medical Waste Management Industry ... This report analyzes the US market for Medical ... Segments: Management & Disposal Services, Collection Equipment, Liquid ...
... 2011 Endologix, Inc. (Nasdaq: ELGX ), ... announced the filing of its annual report on Form ... fourth quarter and full year 2010 financial results. ... to Endologix,s December 2010 acquisition of Nellix, Inc., the ...
Cached Medicine Technology:US Medical Waste Management Industry 2US Medical Waste Management Industry 3US Medical Waste Management Industry 4US Medical Waste Management Industry 5US Medical Waste Management Industry 6US Medical Waste Management Industry 7US Medical Waste Management Industry 8Endologix Files Form 10-K; Nellix Purchase Price Allocation Finalized 2Endologix Files Form 10-K; Nellix Purchase Price Allocation Finalized 3
(Date:7/31/2014)... Hook Your Ex, a system created by Steve Pratt, ... hungry for their partner, to the point of starvation, that they ... has been taught to hundreds of men and women across the ... Ex review , Shane Michaels agrees this simple trick is genius ... a second chance at getting back together with their ex. ...
(Date:7/31/2014)... United Theological Seminary is pleased to ... Donne and Peter J. Bellini. Both began their teaching ... is a Director of Non-Degree Programs, Mark Abbott, who ... Le Donne, Assistant Professor of New Testament, received a ... Testament, Second Temple Judaism, and Greek courses. His research ...
(Date:7/31/2014)... (PRWEB) July 31, 2014 Cosmetic Town ... best Plastic Surgeons to consumers considering cosmetic treatments. ... their peers whose goal is to educate prospective patients ... are selected through a validated referral system that helps ... the best in their respective fields. , Cosmetic ...
(Date:7/31/2014)... 2014 The VitaSleep FDA cleared ... and provide an easier breathing capacity by slightly adjusting ... that people can breathe easier and helps reduce or ... so that it can meet the needs of each ... often shared by actual customer reviews. Johathan R. ...
(Date:7/31/2014)... Ce-Classes.com has developed a Learning Management ... to pass inspections and audits. Ce-Classes.com can ... accreditation and state licensing criteria by providing their ... administrators can monitor employee compliance with mandatory training ... can be developed based on the policies and ...
Breaking Medicine News(10 mins):Health News:Hook Your Ex Review by Shane Michaels Exposes Steve Pratt And His New Method For Getting Back With The Ex 2Health News:Growing Seminary Welcomes New Faculty 2Health News:The New Doctors’ Directory, Cosmetic Town Does the Research for Consumers of Plastic Surgeries 2Health News:New Dental Device Reviews to Stop Snoring by VitalSleep 2Health News:Company Helps Healthcare Agencies to Pass Inspections and Audits 2Health News:Company Helps Healthcare Agencies to Pass Inspections and Audits 3
... - Certified asthma & allergy friendly(TM) by the Asthma, and Allergy ... ... to More Consumers, ENGLEWOOD CLIFFS, N.J., March 20 ... To help those suffering from,common household allergies, LG Electronics today announced ...
... Next Steps in $128 Million Contract -, GAITHERSBURG, ... today announced positive interim results from the,500-subject Phase 1/2 ... vaccine for H5N1 influenza. The trial met a key ... patch,was used with a single dose of the 45-microgram ...
... IDMI ) today reported financial results for the ... information presented,represents the consolidated results of IDM Pharma, Inc. ... the quarter ended December 31, 2007 were $5.6,million, and ... for the quarter.,Total revenues for the year ended December ...
... Nordic Naturals was,recently named the "Top-Rated ... Vitamin and Supplement Users. Receiving two recognitions, ... #1 Rated Health Food,Store Brand for Consumer ... ratings of all brands considered, throughout 8,different ...
... smokers who were treated for cerebral aneurysms,with coil ... greater risk of developing another aneurysm, say neurological ... in the first-known study of its kind. , ... of the Journal of Neurosurgery, researchers found there ...
... March 19 Patrick G. Ryan, founder,and executive chairman ... Aon effective August 1, 2008. Aon is the world,s ... human,capital consulting., Ryan commented, "The transition to a ... is complete. Aon is extremely well-positioned,for continued growth and ...
Cached Medicine News:Health News:LG Electronics Debuts Unique Allergen-Reducing Steam Washer/Dryer Combo 2Health News:LG Electronics Debuts Unique Allergen-Reducing Steam Washer/Dryer Combo 3Health News:LG Electronics Debuts Unique Allergen-Reducing Steam Washer/Dryer Combo 4Health News:Study Finds Single Dose of Iomai Patch With Pandemic Flu Vaccine Achieves Protective Levels 2Health News:Study Finds Single Dose of Iomai Patch With Pandemic Flu Vaccine Achieves Protective Levels 3Health News:Study Finds Single Dose of Iomai Patch With Pandemic Flu Vaccine Achieves Protective Levels 4Health News:Study Finds Single Dose of Iomai Patch With Pandemic Flu Vaccine Achieves Protective Levels 5Health News:IDM Pharma Reports 2007 Financial Results 2Health News:IDM Pharma Reports 2007 Financial Results 3Health News:IDM Pharma Reports 2007 Financial Results 4Health News:IDM Pharma Reports 2007 Financial Results 5Health News:IDM Pharma Reports 2007 Financial Results 6Health News:IDM Pharma Reports 2007 Financial Results 7Health News:IDM Pharma Reports 2007 Financial Results 8Health News:IDM Pharma Reports 2007 Financial Results 9Health News:Nordic Naturals Named Top-Rated Supplement Brand in ConsumerLab.com Survey of Vitamin and Supplement Users! 2Health News:Smokers treated for brain aneurysm with coils at higher risk of recurrence 2Health News:Patrick G. Ryan Announces Intention to Retire from Aon 2Health News:Patrick G. Ryan Announces Intention to Retire from Aon 3
For the quantitative determination of total glucose in serum....
Intended for the quantitative determination of glucose in biological fluids. Reaction: endpoint. Wavelength: 340 nm. Linearity: 800 mg/dL (44.4 mmol/L). Single vial, dry powder reagent....
Inorganic phosphorus (UV method) reagent is for the quantitative determination of inorganic phosphorus in human serum....
For the quantitative determination of Inorganic Phosphorus in serum. Linearity: 12.0 mg/dl....
Medicine Products: