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In Vivo Data on Taligen Therapeutics' Pipeline Candidates Presented at the XXII International Complement Workshop
Date:10/7/2008

udies in models for several complement-mediated diseases showed that targeted inhibition of the alternative complement pathway slowed or halted disease progression in these models. Sekine et al. investigated whether TT30 prevented progression of renal disease in a lupus nephritis murine model (Poster #174). TT30 is a fusion protein coupling domains from complement receptor 2 (CR2) with the alternative pathway inhibitor factor H (fH). Treatment with the CR2 domain alone led to decreases in autoantibodies, while treatment with TT30 resulted in additional beneficial effects including significantly reduced renal injury, proteinuria and anti-dsDNA antibody levels compared to controls. Therefore, the dual action of TT30 (CR2 and fH) prevented disease progression in this animal model.

Thurman et al. (Poster #171) compared the effect of systemic administration of TT30 to the effect of CR2-Crry in an airway hyper-responsiveness asthma animal model. CR2-Crry is an inhibitor of the alternative, classical and lectin complement pathways whereas TT30 inhibits only the alternative pathway. The study showed that both TT30 and CR2-Crry significantly reduced airway hyper-responsiveness. This suggests that targeting the alternative complement pathway, while keeping the classical and lectin complement pathways unaffected, may be sufficient to control complement-mediated diseases and thus reduce the risk of infection.

Wet AMD animal model study suggests an alternative to intraocular drug administration

Currently marketed therapies for wet AMD require intraocular injections. In a wet AMD animal model, Rohrer et al. (Poster #202) tested whether TT30 could be effective in preventing progression of choroidal neovascularization following argon laser photocoagulation if TT30 was injected intraocularly or intravenously. The Rohrer team demonstrated that TT30 prevented progression of choroidal neovascularization regardless of the mode of administration. Besides adding furth
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