Navigation Links
In Vitro Study of Adamas Pharmaceuticals' Triple Combination Antiviral Drug Therapy Shows Activity Against Drug-Resistant Influenza Viruses
Date:9/13/2009

e antiviral therapy for serious influenza infections, with the potential to address the current limitations of antiviral potency and drug resistance."

The study results showed that the triple combination was highly synergistic in vitro, and the synergy of TCAD therapy was significantly greater than the synergy of double combinations against both susceptible and resistant viruses. Importantly, the study revealed that oseltamivir and amantadine in the triple combination contributed to antiviral activity against oseltamivir-resistant and amantadine-resistant viruses, respectively, at concentrations where they had no activity as single agents, and at concentrations that are clinically relevant.

According to the study investigators, virtually all clinical isolates of seasonal influenza in 2009 have been found to be resistant to either the adamantanes or oseltamivir. They caution that the development of resistance to currently recommended therapies may undermine their utility. While currently limited in scope, the first cases of multi-drug resistant novel influenza A/H1N1 flu are also now being reported and will need to be addressed.(1)

"Drug resistant seasonal influenza and emerging cases of multi-drug resistant novel influenza A/H1N1 virus are creating an immediate need for alternative strategies to currently available antiviral therapies," said Gregory Went, Ph.D., Chief Executive Officer and Chairman of Adamas. "The impact to the healthcare system as a result of increased admissions for those with serious flu is exacerbated during a pandemic so we believe our work is very timely. "

The CDC and WHO recommend the use of antiviral drugs for treating serious cases of influenza infection(2). Antiviral drugs that are both potent and effective against drug-resistant strains also may be important for limiting transmission of the swine flu virus during the pandemic.(3)

The da
'/>"/>

SOURCE Adamas Pharmaceuticals, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Georgia Reproductive Specialists Participates in Largest-Ever In Vitro Fertilization Clinical Trial in the World
2. Oritavancin Demonstrates Superior In Vitro Activity to Vancomycin and Metronidazole Against C. Difficile Bacteria
3. Targanta Presents First Data Demonstrating In Vitro Activity and In Vivo Efficacy of Prodrugs in Osteomyelitis Models
4. Oritavancin Demonstrates Potent and Rapid In Vitro Activity Against MRSA, VRE and Other Strains of Resistant Bacteria
5. MatTeks EpiDerm In Vitro Tissues Headed for Validation in Europe
6. Sequoia Pharmaceuticals Presents In Vitro and First-in-Human Data Supporting Further Development of SPI-256, a Novel Investigational Protease Inhibitor
7. New Data Show In Vitro Potency of Doripenem Against Resistant Bacteria
8. Tobira Therapeutics Inc. Announces In Vitro Data of TBR-652 for the Treatment of HIV
9. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
10. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
11. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... 2014   Fruit Street Health (Fruit Street), ... round of funding. The round, which ... series of individual investors, the majority of whom are ... initial round are; Houston Cardiology Consultants Partner Asif ... Childs, Rapha Family Medicine Practice Owner Frances Ilozue ...
(Date:9/18/2014)... N.J. , Sept. 18, 2014  ADM ... Gianluca DeNovi , Ph.D. to its corporate Advisory ... is an instructor at the Harvard Medical School ... of Rome.  He received his Masters degree in ... Control Systems from the University of Bologna. After spending ...
(Date:9/18/2014)... MEETING, Pa. , Sept. 18, 2014 ... trial solutions, was recognized as the Disruptive ... for its ePharmaONE cloud-based eClinical platform. This ... and electronic trial master file (eTMF), a ... solution, and ePharmaSolutions, ReferralPlus+ patient screening and ...
Breaking Medicine Technology:Fruit Street Health Secures First Round Of Seed Funding Led By Group Of Medical Industry And Technology Leaders 2Fruit Street Health Secures First Round Of Seed Funding Led By Group Of Medical Industry And Technology Leaders 3ADM Tronics Appoints Gianluca DeNovi, Ph.D. To Advisory Board 2ADM Tronics Appoints Gianluca DeNovi, Ph.D. To Advisory Board 3ePharmaSolutions Named 2014 Disruptive Innovator of the Year for its ePharmaONE eClinical Platform 2ePharmaSolutions Named 2014 Disruptive Innovator of the Year for its ePharmaONE eClinical Platform 3
(Date:9/18/2014)... don,t worry, it,s a good thing! As scientists have ... bad. Many active enzymes and bacteria are merely benign, ... important part of our digestive system or can help ... an opportunistic yeast pathogen and model organism for research, ... ecosystem. However, when our immune system is stressed on ...
(Date:9/18/2014)... Non-governmental stakeholders will convene a one-day conference at ... George Washington University on September 25, 2014 to discuss ... towards GHSA implementation. The purpose of this event is ... over the next five years, including action plans to ... 2014 launch of the GHSA, international organizations and more ...
(Date:9/18/2014)... (September 18, 2014) The National Institutes of ... from a four-year, $1.3 million grant to the Los ... the research and development of a vaccine to protect ... Methicillin-resistant Staphylococcus aureus (MRSA). , The ... the NIH awarded the grant to LA BioMed infectious ...
(Date:9/18/2014)... DURHAM, N.C. Dangerous new pathogens such as the ... even ancient scourges such as the bubonic plague are ... body responds to infections. , In a study published ... , researchers at Duke Medicine and Duke-NUS Graduate Medical ... cause bubonic plague hitchhike on immune cells in the ...
(Date:9/18/2014)... ChopChop founder Sally Sampson is challenging former ... Massachusetts’s winner of the First Lady’s Healthy Lunchtime Challenge, to ... Eastern bean dip. Watch as Bill and Yonah cook side-by-side ... own healthy dips at home. The cooking demonstration will take ... Talk About Food Festival in Copley Square on September ...
Breaking Medicine News(10 mins):Health News:Everything in moderation: Micro-8 to study regulating pathogens in space 2Health News:Everything in moderation: Micro-8 to study regulating pathogens in space 3Health News:Non-governmental stakeholders to discuss the Global Health Security Agenda 2Health News:LA BioMed receives NIH grant to study vaccine for hospital-acquired infections 2Health News:New insights on an ancient plague could improve treatments for infections 2Health News:Award-Winning Cooking Magazine for Kids Challenges Former White House Pastry Chef and 10-Year-Old Chef to Cook Up a Healthy Snack 2Health News:Award-Winning Cooking Magazine for Kids Challenges Former White House Pastry Chef and 10-Year-Old Chef to Cook Up a Healthy Snack 3
... surveillance, planning and interagency coordinationWASHINGTON, May 8 Environmental ... the Natural Resources Defense Council (NRDC) praised legislation introduced ... climate change. The bill is sponsored by the ... Commerce Committee,s Subcommittee on Health , U.S. Rep. ...
... This Sunday, individuals all over the nation ... women who gave them life: their mothers. While people in ... International Breast Milk Project (IBMP) hopes to inspire some to ... that helps mothers in the United States send their breast ...
... Kaiser Foundation Health Plan, Inc., Kaiser Foundation Hospitals and ... $10.6 billion for the quarter ended March 31, 2009, ... year. Operating income in the first quarter was ... of 2008. Declines in the financial markets impacted ...
... May 8 Misonix, Inc. (Nasdaq: MSON ... technology, which in Europe is used for the ablation ... has entered into a definitive, 5-year distribution agreement with ... in Barcarena, Portugal, expanding on and replacing a previous ...
... - Majority have not changed their behavior or lifestyle ... May 8 A new national study among 1,477 ... become less concerned about the impact that the H1N1 ... http://www.newscom.com/cgi-bin/prnh/20071204/NYTU133LOGO )Results ...
... Family, Inc. (Nasdaq: AFAM ), a leading regional ... Yarmuth, President and Chief Executive Officer, and Steve Guenthner, Senior ... at two upcoming investor conferences. The first presentation will ... Stock Conference at the Four Seasons Hotel in Chicago, IL., ...
Cached Medicine News:Health News:New Bill to Fund Climate Change and Public Health Preparedness Praised by Environmental and Health Groups 2Health News:New Bill to Fund Climate Change and Public Health Preparedness Praised by Environmental and Health Groups 3Health News:New Bill to Fund Climate Change and Public Health Preparedness Praised by Environmental and Health Groups 4Health News:International Breast Milk Project Helps Mothers Worldwide 2Health News:Kaiser Foundation Health Plan and Hospitals Report First Quarter 2009 Financial Results 2Health News:Kaiser Foundation Health Plan and Hospitals Report First Quarter 2009 Financial Results 3Health News:Misonix Announces New HIFU Distribution Agreement For Portugal 2Health News:Misonix Announces New HIFU Distribution Agreement For Portugal 3Health News:Docs Are Becoming Less Concerned About H1N1 Swine Flu 2Health News:Docs Are Becoming Less Concerned About H1N1 Swine Flu 3Health News:Docs Are Becoming Less Concerned About H1N1 Swine Flu 4Health News:Almost Family to Present at Two Upcoming Conferences 2
Inquire...
... Novas Point-of-Care Manager is ... gas and critical care ... the industry. PDM ... workstation designed to effortlessly ...
... The ISI Micro Nest is the wall-mounted organizer ... a variety of sizes and diameters. The Micro ... the right brush for the cleaning task. These ... specifically for those hard-to-clean instruments such as cannulas. ...
... is the non-silicone lubricant designed to "spot" ... lubricates sticky pivot points, hinges, box joints ... allows you to lubricate with precision. Safe ... Ideal for carts, hinges, medical equipment, and ...
Medicine Products: