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In Relapsed/Refractory Multiple Myeloma, Thought Leaders Are Optimistic that the Combination of Carfilzomib, Lenalidomide and Dexamethasone Will Be the Most Efficacious Regimen
Date:5/14/2013

and tolerability attribute that is most important to prescribing decisions in relapsed/refractory multiple myeloma, thus indicating the persisting high level of unmet need for therapies with a more favorable peripheral neuropathy profile.

"Despite the improvements effected by carfilzomib and the subcutaneous formulation of bortezomib (Takeda/Janssen-Cilag/Janssen's Velcade) on the incidence of peripheral neuropathy associated with standard intravenous bortezomib, our survey results suggest that further improvement in neurotoxicity remains a key opportunity for product differentiation," said Decision Resources Senior Business Insights Analyst Khurram Nawaz , M.Sc. "Early-stage clinical data suggest that the oral proteasome inhibitor MLN9708 (Takeda/Millennium) is associated with little peripheral neuropathy. MLN9708 has the potential to gain a competitive edge over currently available proteasome inhibitors if it can replicate these promising results in its ongoing Phase III trial, provided it is at least as efficacious as bortezomib and carfilzomib."

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