Navigation Links
In Pilot Study, a Peptide Controls Blood Sugar in People with Congenital Hyperinsulinism
Date:8/1/2012

PHILADELPHIA, Aug.1, 2012 /PRNewswire-USNewswire/ -- A pilot study in adolescents and adults has found that an investigational drug shows promise as the first potential medical treatment for children with the severest type of congenital hyperinsulinism, a rare but potentially devastating disease in which gene mutations cause insulin levels to become dangerously high.

"There is currently no effective medicine for children with the most common and most severe form of hyperinsulinism," said study leader Diva D. De Leon, M.D., a pediatric endocrinologist at The Children's Hospital of Philadelphia. "Our new research shows that this investigational drug, a peptide called exendin-(9-39), controls blood sugar levels in people, a very promising result."

The study appeared today online ahead of print in the journal Diabetes.

In congenital hyperinsulinism (HI), mutations disrupt the insulin-secreting beta cells in the pancreas. Uncontrolled, excessive insulin levels thus sharply reduce blood glucose levels, a condition called hypoglycemia. If untreated, hypoglycemia may cause irreversible brain damage or death in children. Congenital HI occurs in an estimated one in 50,000 U.S. children, with a higher incidence among Ashkenazic Jews and certain other groups.

The standard treatment for some forms of congenital HI is diazoxide, a drug that controls insulin secretion by opening potassium channels in beta cells. However, this drug does not work in the most common types of HI, in which mutations prevent these potassium channels from forming.

When abnormal beta cells occur only in a discrete portion of the pancreas, precise surgery on the tiny organ can remove the lesion and cure HI. The Congenital Hyperinsulinism Center at The Children's Hospital of Philadelphia is a world leader in diagnosing such lesions and performing the curative surgery on newborns.

However, in roughly half of congenital HI cases, abnormal cells are dif
'/>"/>

SOURCE The Children's Hospital of Philadelphia
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Bluechiip Receives First Sales Order from ATCC after Completion of Successful Pilot Trial
2. Protein and Peptide-based Therapeutics - Trends in Drug Discovery and Development
3. Unigenes Potent, Anorexigenic Peptide, UGP281, Demonstrates Dramatic Dose Dependent Reductions in Food Intake with Subsequent Significant Body Weight Reduction in Preclinical Studies
4. MinuteClinic Joins with American Heart Association to Help Americans Reduce High Blood Pressure
5. Gentris Corporation Announces Collaboration to Study Blood Stability
6. New Study Reveals Wide Variation in Blood Transfusion Practices During Surgery
7. New Plastic Blood Culture Bottles Increase Lab Convenience While Maintaining High-Quality Standards
8. Global Growth Factors (Blood And Tissue) Industry
9. Diabetes Care Devices in Emerging Countries (China, India, Brazil) to 2017 - Greater Awareness is Increasing Demand for Self-Monitoring of Blood Glucose (SMBG) in the Home Care Segment
10. Spot On Sciences Awarded $1 Million DARPA Grant to Develop a Blood Sample Collection Device
11. OICR funds Fluorinov Pharma Inc. to further develop its novel drug for the treatment of blood cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... Dec. 18, 2014  Decision Resources Group finds that ... States will increase to a value of ... driven by expansion in the large direct energy device ... be increasingly adopted due to the advantages they offer ... key findings from Decision Resources Group,s coverage of the ...
(Date:12/19/2014)... Ky. , Dec. 18, 2014 Baptist Health ... States to receive full Atrial Fibrillation with Electrophysiology ... Care (SCPC). Atrial fibrillation is the most common ... that in some cases can lead to stroke and possible ... United States have atrial fibrillation and the numbers ...
(Date:12/19/2014)... and LYON, France , Dec. 19, ... LLY ) and Adocia (Euronext Paris: FR0011184241 – ADOC) ... an ultra-rapid insulin, known as BioChaperone Lispro, for treatment ... BioChaperone Lispro relies on Adocia,s proprietary BioChaperone® technology and ... and Adocia will develop BioChaperone Lispro with the goal ...
Breaking Medicine Technology:U.S. Laparoscopic Device Market Will Reach Over $4.3 Billion by 2023 2U.S. Laparoscopic Device Market Will Reach Over $4.3 Billion by 2023 3Baptist Health Lexington First in the Nation to Receive Atrial Fibrillation with EPS Accreditation 2Baptist Health Lexington First in the Nation to Receive Atrial Fibrillation with EPS Accreditation 3Lilly and Adocia Announce Alliance to Co-Develop Ultra-Rapid Insulin Based on BioChaperone Technology 2Lilly and Adocia Announce Alliance to Co-Develop Ultra-Rapid Insulin Based on BioChaperone Technology 3
(Date:12/19/2014)... 19, 2014 Energy Textiles is ... now available. Celliant, the world’s leading responsive textile, ... pillowcases. , There are a number of benefits ... increased oxygenation and balanced body temperature; which can ... pain relief; enhanced athletic performance; and overall wellness. ...
(Date:12/19/2014)... Santa Rosa, CA (PRWEB) December 19, 2014 ... 2x4 and 5x5 SuperClone Rooms. SuperCloset continues to offer ... grow solutions. Pair one of the new SuperClone Rooms ... truly professional, perpetual, and turnkey indoor hydroponic grow room ... cloner in the world, SuperCloset’s SuperPonic SuperCloner 50 ...
(Date:12/19/2014)... 2014 An evening dress is perfect for ... closet. Discount-Dress.com, a distinguished dresses retailer, has unveiled its new ... in this great shopping platform. Customers can view ... hard work, Discount-Dress.com has been accepted and praised by customers ... easier shopping stage for clients. In order to expand its ...
(Date:12/19/2014)... (HealthDay News) -- New research warns parents that buying an older ... Nearly half of teen drivers killed in the United States ... 11 years old and often lacked important safety features that are ... teen drivers killed in crashes were in cars at least six ... old, 31 percent were in cars 11 to 15 years old, ...
(Date:12/19/2014)... -- Potentially illness-causing E. coli bacteria were found on ... to a new study. Researchers checked cilantro, basil ... markets in Los Angeles and Orange counties in California, ... samples tested, 24 percent were positive for E. coli. ... researchers. Both types of bacteria can cause sometimes ...
Breaking Medicine News(10 mins):Health News:Energy Textiles Launches Celliant Revitalizing Bedsheets 2Health News:SuperCloset Continues to Innovate with New Complete Indoor Grow Room Packages, The SuperClone Rooms are the Newest Addition to the Award Winning SuperRoom Lineup 2Health News:Attractive Evening Dresses Announced by Discount-Dress.com 2Health News:Older Cars a Bad Choice for Younger Drivers 2Health News:E. Coli Germs Found on Farmers Market Herbs 2
... pass,companion bill and send measure to President, ALBANY, ... of the Protecting the Medicaid Safety Net Act of,2008, ... The bill,prevents massive increases in costs for people in ... "Today,s vote is a victory for all New York ...
... antibiotics sufficient to treat eye disease, study finds ... communities with moderate levels of the eye disease trachoma, ... with the antibiotic azithromycin may be sufficient to eliminate ... at the London School of Hygiene & Tropical Medicine,s ...
... needed to prove that oversulfated chondroitin sulphate caused deaths, ... researchers say they,ve confirmed that lots of the blood ... a man-made chemical called oversulfated chondroitin sulfate. , ... Biotechnology . , And, according to a paper published ...
... at the Congressional Gold Medal ceremony in the Capitol ... Below are the,Speaker,s remarks:, "Good morning. It is ... the House and Senate to honor Dr. Michael DeBakey. ... Representative Al,Green, and others who worked with them for ...
... 75-cent Per Pack Increase Would Help Raise $390 ... Ohio leaders should,fund a proposed economic stimulus plan ... prevention funds, recommends a report released,today by the ... this tobacco tax alternative would reduce smoking, save ...
... Corporation,(NYSE: STE ) today announced that its Board ... amount of $0.06 per common share. The,dividend is payable ... close of,business on May 14, 2008., About STERIS, ... a healthier today and,safer tomorrow through knowledgeable people and ...
Cached Medicine News:Health News:AARP Thanks New York's Representatives for Supporting Bill to Protect People in Medicaid 2Health News:Annual Trachoma Treatments May Be Unnecessary 2Health News:Researchers Identify Contaminant in Tainted Heparin 2Health News:Researchers Identify Contaminant in Tainted Heparin 3Health News:Pelosi: 'By Literally Fixing Broken Hearts, Dr. DeBakey Has Given Hope and Health to Millions' 2Health News:New Report: Increasing Ohio's Tobacco Tax Would Fund Economic Stimulus Plan and Preserve Highly-Successful Tobacco Prevention Program 2Health News:New Report: Increasing Ohio's Tobacco Tax Would Fund Economic Stimulus Plan and Preserve Highly-Successful Tobacco Prevention Program 3Health News:New Report: Increasing Ohio's Tobacco Tax Would Fund Economic Stimulus Plan and Preserve Highly-Successful Tobacco Prevention Program 4Health News:STERIS Corporation Declares Regular Quarterly Dividend 2Health News:STERIS Corporation Declares Regular Quarterly Dividend 3
... Triad Plus PVP-I Prep Gel ... PVP-I Prep Gel is film forming, ... action that has been known to ... gram-positive bacteria (including antibiotic resistant), fungi, ...
... HIBICLENS bonds with ... a protective, germ-killing field. ... fast acting antimicrobial effect, ... irritation potential promotes compliance ...
Aplicare's disposable 1-ounce pouches are designed for individual application and are ideal for reducing waste. They are used in nursing homes, home healthcare settings, blood banks, laboratories, em...
Aplicare's disposable 1-ounce pouches are designed for individual application and are ideal for reducing waste. They are used in nursing homes, home healthcare settings, blood banks, laboratories, em...
Medicine Products: