Navigation Links
In Blood Vessel Stents, Innovative Materials Allow Better Control, Delivery of Gene Therapy
Date:4/15/2008

PHILADELPHIA, April 15 /PRNewswire-USNewswire/ -- Before gene therapy becomes practical for treating human diseases, researchers must master the details of safe and effective delivery. Cardiology researchers at The Children's Hospital of Philadelphia have advanced delivery techniques by creating a versatile synthetic material that can bind to a variety of gene therapy vectors and can be custom-designed for controlled local release of therapeutic genes at a disease site.

In an animal study, the research team used their new synthetic formulation to bind adenoviruses to bare metal stents, tiny metal scaffolds inside the carotid arteries of rats. Adenovirus served as a gene therapy vector to carry genes for an enzyme that significantly reduced restenosis, the hazardous narrowing of a blood vessel that often occurs despite the presence of a stent designed to hold it open.

Although the materials are in an early stage, the hope is that this method may help to treat artery disease in people. "We developed a synthetic gene delivery system that can be used for any gene therapy vector, not just adenoviruses," said study leader Robert J. Levy, M.D., the William J. Rashkind Chair of Pediatric Cardiology at The Children's Hospital of Philadelphia. "Furthermore, this new formulation allows us to increase the dosage of gene therapy vectors delivered, and we can tune the materials for sustained release over a longer time period."

Levy's group reported its study this week in the online version of the journal Circulation, published by the American Heart Association.

Over the past decade, stents have become increasingly useful in treating constricted blood vessels in heart disease and in peripheral artery disease. Stents, which expand partially blocked blood vessels to improve circulation, may be made of bare metal or may have a coating of polymers that release drugs.

Neither type is ideal. Polymer coatings cause inflammation
'/>"/>

SOURCE The Children's Hospital of Philadelphia
Copyright©2008 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3

Related medicine technology :

1. People With Diabetes May Have All-Natural Citrus Supplement To Help Lower Blood Glucose and Cholesterol Levels
2. Microwave Treatments for Enlarged Prostate Cause Blood Pressure Surges
3. Lotrel, a Single-Pill Combination for Treating High Blood Pressure, Reduced Cardiovascular Events by 20% in High-Risk Patients
4. Early Research Suggests Umbilical Cord Blood Cell Therapy May Reduce Progression of Alzheimers Disease
5. Sangart Completes Enrollment in Phase III Study of Its Novel Blood Substitute Hemospan
6. Trellis(R) Catheter Removes Blood Clots Quickly, Restoring Blood Flow in 771 Deep Vein Thrombosis (DVT) Patients
7. New Deep Vein Thrombosis (DVT) Registry Data Show Clot Quickly Removed, Blood Flow Restored in Large Patient Registry
8. Gen-Probe Submits U.S. Regulatory Application for Additional Approval of PROCLEIX(R) ULTRIO(R) Blood Screening Assay
9. American Heart Association Journal Report: Reducing Kids Salt Intake May Lower Soft Drink Consumption, Reducing Obesity, High Blood Pressure and Later Health Risks
10. Study Shows: New Blood Test Proven Six Times More Effective For Tuberculosis Control
11. Novel Small Molecule Therapy Shows Benefit for Anemic Patients Via Hydration of Red Blood Cells

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/25/2009)...OandSTAFA,Switzerland,Nov.25/PRNewswire/-- FromNov...vehearingsolutions,presentedthesecondeditionoftheH...needsoftheolderpopulation.Theconferencebroughttoge...worldandmorethan250clinicianswhoworkeverydaywithol...eriencesanddiscussthelatestresearchandtrendsinhear...
(Date:11/25/2009)...CORDOVA,Calif.,Nov.25/PRNewswire/--AMPACFineChemic...n(Nasdaq: APFC )announcedtodaythatitreceivedtheEnv...eAnnualStatewideEnvironmentalSummit,sponsoredbythe...TA),theIndustrialEnvironmentalAssociation(IEA)andt...anDiego.Thisisthemostprestigiousawardavailablefrom...
(Date:11/25/2009)...ITY,Calif.,Nov.25/PRNewswire-FirstCall/--Abaxis,In...ringpoint-of-carebloodanalysissystems,announcedtod...er,willpresentatthe21stAnnualPiperJaffrayHealthCar...TheconferencewillbeheldattheNewYorkPalaceHotelinNe...s,manufacturesandmarketsportablebloodanalysissyste...
Breaking Medicine Technology:Phonak Successfully Hosts Hearing Care for Adults 2009 Conference 2Phonak Successfully Hosts Hearing Care for Adults 2009 Conference 3AMPAC Fine Chemicals Receives Prestigious Award at California's Annual Statewide Environmental Summit 2VA Summit Frames Plan to End Veteran Homelessness 60879 1VA Summit Frames Plan to End Veteran Homelessness 60879 2Hospira to Present at Piper Jaffray 21st Annual Health Care Conference Dec 2 60875 1McNeil Consumer Healthcare Announces Voluntary Recall of Certain Lots of TYLENOL 28R 29 Arthritis Pain 100 Count with EZ OPEN CAP 6065 1McNeil Consumer Healthcare Announces Voluntary Recall of Certain Lots of TYLENOL 28R 29 Arthritis Pain 100 Count with EZ OPEN CAP 6065 2
...boost to,HIV prevention research, Merck & Co., Inc... the non-profit International Partnership for,Micr...ompound for use as a,potential vaginal microbicide...lass of antiretroviral,molecules known as gp41 fus...venting the virus from fusing with the surface of ...
...tality of scientific,data submitted in recent mont...in preparation for the March 13th Oncologic Drugs ...rythropoiesis-stimulating agents (ESAs) are,safe a...bel to treat,chemotherapy- induced anemia (CIA). E...ents as the only proven therapeutic alternative to...
Other Medicine Technology:Microbicide Developer Receives License for Novel HIV Microbicide Candidate From Merck & Co., Inc. 2Microbicide Developer Receives License for Novel HIV Microbicide Candidate From Merck & Co., Inc. 3Totality of Available Data Reaffirms PROCRIT(R) (Epoetin alfa) Is Safe and Effective When Used Appropriately as Labeled to Treat Chemotherapy-Induced Anemia 2Totality of Available Data Reaffirms PROCRIT(R) (Epoetin alfa) Is Safe and Effective When Used Appropriately as Labeled to Treat Chemotherapy-Induced Anemia 3Totality of Available Data Reaffirms PROCRIT(R) (Epoetin alfa) Is Safe and Effective When Used Appropriately as Labeled to Treat Chemotherapy-Induced Anemia 4Totality of Available Data Reaffirms PROCRIT(R) (Epoetin alfa) Is Safe and Effective When Used Appropriately as Labeled to Treat Chemotherapy-Induced Anemia 5Totality of Available Data Reaffirms PROCRIT(R) (Epoetin alfa) Is Safe and Effective When Used Appropriately as Labeled to Treat Chemotherapy-Induced Anemia 6
(Date:11/25/2009)..., EDINA,Minn.,Nov.25/PRNewswire-USNewswire/--Whe...st.Butachiropractorcanalsogivepatientsthehelptheyn...swhereyourjaw(mandible)contacts/connectswithyoursk...ciatedwithTMJdysfunctionarepainwithchewing,clickin...fromTMJdysfunctionincluding:headaches,fatigue,slee...
(Date:11/25/2009)..., TORONTOandCALGARY,Nov.25/PRNewswire/-Sentinell...ceImaging(MRI)coilsandsoftwareandCalgaryScientific...s,haveintroducedawebversionofAegis(TM)Breast4DAdva...erfaceisthefirsttrulyzero-footprintWebclientbasedm...,sPureWeb(TM)platformallowsforzero-footprintaccess...
(Date:11/25/2009)..., SILVERSPRING,Md.,Nov.25/PRNewswire-USNewswire/...CenterforDrugEvaluationandResearch,titled"ADifficu...earsintheNov.26,2009issueofTheNewEnglandJournalofM...in/prnh/20090824/FDALOGO ) ,, Inthearticle,Wood...sstopainmedicationforthosewhoneeditandmanagingther...
(Date:11/25/2009)..., BroadPoliticalEndorsements,Business,andPressJ...ewswire-USNewswire/--Onceagain,theNationalBipolarF...ationendorsingtheir"Safe,tilStable"program,whichis...reforbipolardisorder.Today,theNationalBipolarFound...xpressPriorityMailfromtheLt.GovernorofLouisianaMit...
(Date:11/25/2009)...A fortuitous discovery that grew out of a collabor...potentially offer hope to the nearly 10 million Am...e. , Also known as hardening of the arteries... circulatory problem in which narrowed arteries re...sidered a red flag for vascular disease, heart att...
Breaking Medicine News(10 mins):Health News:Sentinelle Medical Inc. Introduces Aegis(TM) Web Powered By Calgary Scientific's PureWeb Technology 2Health News:Sentinelle Medical Inc. Introduces Aegis(TM) Web Powered By Calgary Scientific's PureWeb Technology 3Health News:First Time-Door is Open for Family Discussion of Bipolar Disorder 2Health News:First Time-Door is Open for Family Discussion of Bipolar Disorder 3Health News:Engineers, doctors at UCLA develop novel material that could help fight arterial disease 2Health News:Engineers, doctors at UCLA develop novel material that could help fight arterial disease 3Health News:Engineers, doctors at UCLA develop novel material that could help fight arterial disease 4
...issue that children,often face on a regular basis,...o communicate effectively to handle a confrontatio...ool bullies. These rivalries can be harmful,to chi...establish and maintain a home environment where,co...
...eedom to Breathe Act, MINNEAPOLIS, Sept. 10 Toda...designed to educate and excite Minnesotans about t...e law that goes into effect,on October 1. The new ...y ClearWay Minnesota(SM). The majority of,the camp...
...es know that damage to a tendon can signal an end ...f scientists, led in part by University of Souther...Songtao Shi, has identified unique cells within th...lls and regenerate tendon-like tissue in the anima...
...at the Stanford University School of Medicine have... cells within living animals. Their goal is to use...of cancer and other diseases. , The probe,s main ...ble to the naked eye but it carries a fluorescent ...
... Press,Club,s 10th Annual 5K race today, which sta...h & F in Washington, Weiner Public News was first ...reporting and op-ed writing,division of Robert Wei...ted over 500 radio and TV interviews. Weiner,webma...
...s to monitor eyesight carefully , , SATUR... to monitor themselves for eyesight problems, whic...the American Geriatrics Society (AGS). If not prop...hanges in vision will not only hinder a person,s a...
Other Medicine News:Health News:Tips for Parents: Teaching Children to Resolve Conflicts 2Health News:Fresh Air Campaign to Showcase Minnesotans' Love of Smoke-Free Air 2Health News:USC researcher identifies stem cells in tendons that regenerate tissue in animal model 2Health News:Molecular probe 'paints' cancer cells in living animals, Stanford researchers find 2Health News:Molecular probe 'paints' cancer cells in living animals, Stanford researchers find 3Health News:Weiner Public News First Media Team at National Press Club 5K 2Health News:Poor Senior Vision Often a Window on Disease 2
...tretch Vascular Grafts have met the challenges of ... for exceptional performance and quality, they hav...dwide. These grafts require no preclotting, resist...e utmost thrombectomy safety. The GORE-TEX Stretch...
...olving techniques for vascular surgery, and the ac...that new, specialized types of graft be developed....atible, but also available in varying sizes and co...X Vascular Graft has long been the prosthetic of c...
...ascular Grafts have met the challenges of the most...Recognized for exceptional performance and quality...geons worldwide. These grafts require no preclotti... and assure utmost thrombectomy safety. The Gore v...
...eg; Vascular Grafts have met the challenges of the...ars. Recognized for exceptional performance and qu...d surgeons worldwide. These grafts require no prec...tion, and assure utmost thrombectomy safety. Gore ...
Medicine Products: