Navigation Links
In Blood Vessel Stents, Innovative Materials Allow Better Control, Delivery of Gene Therapy
Date:4/15/2008

PHILADELPHIA, April 15 /PRNewswire-USNewswire/ -- Before gene therapy becomes practical for treating human diseases, researchers must master the details of safe and effective delivery. Cardiology researchers at The Children's Hospital of Philadelphia have advanced delivery techniques by creating a versatile synthetic material that can bind to a variety of gene therapy vectors and can be custom-designed for controlled local release of therapeutic genes at a disease site.

In an animal study, the research team used their new synthetic formulation to bind adenoviruses to bare metal stents, tiny metal scaffolds inside the carotid arteries of rats. Adenovirus served as a gene therapy vector to carry genes for an enzyme that significantly reduced restenosis, the hazardous narrowing of a blood vessel that often occurs despite the presence of a stent designed to hold it open.

Although the materials are in an early stage, the hope is that this method may help to treat artery disease in people. "We developed a synthetic gene delivery system that can be used for any gene therapy vector, not just adenoviruses," said study leader Robert J. Levy, M.D., the William J. Rashkind Chair of Pediatric Cardiology at The Children's Hospital of Philadelphia. "Furthermore, this new formulation allows us to increase the dosage of gene therapy vectors delivered, and we can tune the materials for sustained release over a longer time period."

Levy's group reported its study this week in the online version of the journal Circulation, published by the American Heart Association.

Over the past decade, stents have become increasingly useful in treating constricted blood vessels in heart disease and in peripheral artery disease. Stents, which expand partially blocked blood vessels to improve circulation, may be made of bare metal or may have a coating of polymers that release drugs.

Neither type is ideal. Polymer coatings cause inflammation
'/>"/>

SOURCE The Children's Hospital of Philadelphia
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. People With Diabetes May Have All-Natural Citrus Supplement To Help Lower Blood Glucose and Cholesterol Levels
2. Microwave Treatments for Enlarged Prostate Cause Blood Pressure Surges
3. Lotrel, a Single-Pill Combination for Treating High Blood Pressure, Reduced Cardiovascular Events by 20% in High-Risk Patients
4. Early Research Suggests Umbilical Cord Blood Cell Therapy May Reduce Progression of Alzheimers Disease
5. Sangart Completes Enrollment in Phase III Study of Its Novel Blood Substitute Hemospan
6. Trellis(R) Catheter Removes Blood Clots Quickly, Restoring Blood Flow in 771 Deep Vein Thrombosis (DVT) Patients
7. New Deep Vein Thrombosis (DVT) Registry Data Show Clot Quickly Removed, Blood Flow Restored in Large Patient Registry
8. Gen-Probe Submits U.S. Regulatory Application for Additional Approval of PROCLEIX(R) ULTRIO(R) Blood Screening Assay
9. American Heart Association Journal Report: Reducing Kids Salt Intake May Lower Soft Drink Consumption, Reducing Obesity, High Blood Pressure and Later Health Risks
10. Study Shows: New Blood Test Proven Six Times More Effective For Tuberculosis Control
11. Novel Small Molecule Therapy Shows Benefit for Anemic Patients Via Hydration of Red Blood Cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/6/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/58tdl6/pharmaceutical ) ... Sodium Chloride Market by Applications, by Region - Industry ... offering. The pharmaceutical grade sodium chloride market ... 2014 and 2019 in terms of volume, and the ... The report on Pharmaceutical grade sodium chloride ...
(Date:7/6/2015)... , July 6, 2015  Impax Laboratories, Inc. ... Hsu , Ph.D. has resigned from the Company,s Board ... Dr. Hsu was a co-founder of Impax in 1995 ... Officer from October 2006 until April 2014. ... Wilkinson , Impax,s President and Chief Executive Officer stated, ...
(Date:7/6/2015)... China Information Technology, Inc. (the "Company" or ... cloud-based platform, exchange, and big data solutions in ... launched its mobile app for Healthcare One Pass, ushering ... mobile devices. The Company jointly hosted the launch ceremony ... and Shenzhen News Net.   The mobile app ...
Breaking Medicine Technology:Global Pharmaceutical Grade Sodium Chloride Market Report 2015 2Global Pharmaceutical Grade Sodium Chloride Market Report 2015 3Impax Announces Resignation of Larry Hsu, Ph.D. from Board of Directors 2Impax Announces Resignation of Larry Hsu, Ph.D. from Board of Directors 3Impax Announces Resignation of Larry Hsu, Ph.D. from Board of Directors 4Impax Announces Resignation of Larry Hsu, Ph.D. from Board of Directors 5CNIT Launches the Mobile App for Healthcare One Pass 2CNIT Launches the Mobile App for Healthcare One Pass 3CNIT Launches the Mobile App for Healthcare One Pass 4
... a privately-held company that develops and manufactures cardiac assist ... for evaluation of the Jarvik 2000® heart for destination ... that it will provide long-term, permanent support to end-stage ... heart transplant. The approval permits fifty medical centers to ...
... Feb. 27, 2012  Swift responses save lives when a ... incidents in Tennessee and Virginia this past month, having ... Care Plan is a life-saving combination. The ... of awareness, preparedness and action in keeping students healthy, ...
Cached Medicine Technology:JARVIK HEART Announces FDA Conditional Approval of Trial Using the Jarvik 2000® Heart for Destination Therapy 2JARVIK HEART Announces FDA Conditional Approval of Trial Using the Jarvik 2000® Heart for Destination Therapy 3School Nurses Save Lives with Epinephrine Auto-Injectors 2School Nurses Save Lives with Epinephrine Auto-Injectors 3
(Date:7/5/2015)... , ... July 05, 2015 , ... Women’s Excellence ... college) at their Lake Orion location. The special consists of 2 months of unlimited ... Wellness, powered by Movestrong is located at 1410 South Lapeer Road in Lake Orion. ...
(Date:7/4/2015)... (PRWEB) , ... July 04, 2015 , ... ... Plastic Surgeons published the results of an annual member survey , detailing ... United States. More recently, the group broke that raw data down into charts ...
(Date:7/4/2015)... ... July 04, 2015 , ... Tyler Boden, Project Developer of ... expertise from the North American Board of Certified Energy Practitioners (NABCEP®), and is ... respected and well established national certification organization for renewable energy professionals. Designation as ...
(Date:7/3/2015)... ... , ... On June 30th SEO authority and veteran Internet ... "Page One Engine" . The program, which has been hailed as the ... well-known marketers. HonestyFirstReviews.com's Tiffany Hendricks has joined the party, publishing an in-depth review ...
(Date:7/3/2015)... , ... July 03, 2015 , ... Renowned rhinoplasty ... dates for the 2016 Dallas Rhinoplasty Symposium . To be held from March ... meeting will be held at the Westin Galleria Dallas. , Designed to take participants ...
Breaking Medicine News(10 mins):Health News:The ‘South Atlantic’ Frequently Chooses Tummy Tuck for Plastic Surgery, Jacksonville, FL, Doctor Notes 2Health News:The ‘South Atlantic’ Frequently Chooses Tummy Tuck for Plastic Surgery, Jacksonville, FL, Doctor Notes 3Health News:Local Solar Professional Earns Industry's Most Prestigious Certification 2Health News:Local Solar Professional Earns Industry's Most Prestigious Certification 3Health News:Page One Engine - Review Of Dori Friend's SEO Training Course Released 2Health News:Dr. Rod J. Rohrich Announces the Dates for 2016 Dallas Rhinoplasty Symposium 2Health News:Dr. Rod J. Rohrich Announces the Dates for 2016 Dallas Rhinoplasty Symposium 3
... earthquake to ravage China in decades, the task of ... onerous one. The 7.9-magnitude earthquake of 12 May devastated ... and causing extensive property damage. , Among the many ... enemy stray radioactive sources that could complicate relief ...
... 2008: Low bone mineral density in the hand is ... rheumatoid arthritis (RA) and indicates long-term prognosis, according to ... Annual Congress of the European League Against Rheumatism in ... density to be as effective predicting mortality as well-established ...
... France June 12, 2008 -- Biogen Idec ... the first dual-mechanism, lymphotoxin-; (LT-;) and LIGHT pathway ... diseases, including rheumatoid arthritis (RA), during the 2008 ... of Rheumatology at the Le Palais de Congrs ...
... Sales Already Exceed Q1 2008 and Q2 2007 Levels, - ... ... Surgeons, MONROVIA, Calif., June 12 STAAR ... invasive ophthalmic products, today announced that Visian ICL(TM),(Implantable Collamer Lens) sales in ...
... Laurent Claret Will Present Case Studies on the ... and Survival Benefits of Anticancer Agents, MOUNTAIN ... PHST ), a leading provider of software, strategic,consulting, ... announced that Laurent Claret, Ph.D., senior scientist,Pharsight Strategic ...
... A research abstract that will be presented on ... the Associated Professional Sleep Societies (APSS), finds a link ... adolescents with depressive episodes. , The study, authored by ... Brazil, focused on 303 individuals with pediatric bipolar disorder ...
Cached Medicine News:Health News:In quake's aftermath, Chinese sift through rubble for radioactivity 2Health News:Hand bone mineral density is an effective predictor of mortality in rheumatoid arthritis 2Health News:Biogen Idec's baminercept alfa shows promise in patients with rheumatoid arthritis 2Health News:Biogen Idec's baminercept alfa shows promise in patients with rheumatoid arthritis 3Health News:Biogen Idec's baminercept alfa shows promise in patients with rheumatoid arthritis 4Health News:STAAR Surgical's LASIK Alternative Expands U.S. Market Gains 2Health News:STAAR Surgical's LASIK Alternative Expands U.S. Market Gains 3Health News:STAAR Surgical's LASIK Alternative Expands U.S. Market Gains 4Health News:Pharsight to Present on Oncology Modeling and Simulation at PAGE Annual Meeting 2Health News:Pharsight to Present on Oncology Modeling and Simulation at PAGE Annual Meeting 3Health News:Poor sleep linked to suicidal behavior among children and adolescents with depressive episodes 2Health News:Poor sleep linked to suicidal behavior among children and adolescents with depressive episodes 3
... utilize Linvatecs exclusive Shockflex prism system to ... Using the latest technology, our 3CCD Camera ... and brightness. The Camera Heads are available ... configured with a number of optical couplers ...
... an integrated coupler can be steam sterilized using ... it is cool to the touch and ready ... Smarthead technology allowing each head to store procedure ... head has been used is displayed on the ...
... invasive surgery is founded on superior medical ... of 3-Chip cameras, 1-Chip cameras, Light sources, ... your demanding needs., ,Superior resolution and ... our 3-Chip cameras, and are the benchmark ...
... high-resolution 1-Chip Camera System provides easy-to-use features, ... small scope. The camera head construction is ... ,Complete 1-Chip Camera System for Microscopic Application, ... Camera Control Unit (CCU) with power cord ...
Medicine Products: