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In Battle Against Healthcare Associated Infections: Continuing Research on Friendly Bacteria
Date:5/4/2011

CLEVELAND, May 4, 2011 /PRNewswire/ -- Ganeden Biotech announced today that the company will present new in vivo data on the effect of its GanedenBC30 probiotic strain in C. diff infection at the Digestive Disease Week (DDW) conference in Chicago, Ill., from May 7-10, 2011. Jointly with its collaborator, Dr. Leo R. Fitzpatrick, Associate Professor from the Department of Pharmacology, Penn State College of Medicine, Pa., Ganeden will present data on the effect of GanedenBC30 on impacting C. diff-induced colitis in mice. Following an established protocol for colitis induced by C. diff, GanedenBC30 demonstrated a significant effect on improving stool consistency and also improved animal survival and other indices of colonic inflammation.

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Clostridium difficile (C. diff) is a species of gram-positive bacteria that causes severe diarrhea and other intestinal disease when competing, friendly bacteria in the gut flora are wiped out by antibiotics.  C. diff infection typically occurs in hospital or healthcare settings after antibiotic administration.  The U.S. Agency for Healthcare Research and Quality (AHRQ) estimates that C. diff infections occur in 10 of every 1,000 hospitalizations.  AHRQ research found that patients with C. diff were hospitalized almost three times longer than uninfected patients and that the in-hospital death rate for patients with C. diff was almost five times the overall rate.


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