Navigation Links
Improved Endoscopy Method Increases Detection of Esophageal Pre-Cancer by Over 40 Percent
Date:5/19/2011

NEW YORK, May 19, 2011 /PRNewswire/ -- Two studies published in Digestive Diseases and Sciences have demonstrated that an improved method for performing the standard upper endoscopy examination done on over eight million Americans with heartburn each year increases the detection of pre-cancerous cells in the esophagus by over 40 percent.  Esophageal adenocarcinoma has increased by 600 percent over the last 25 years, making it the fastest growing form of cancer in the United States.  It is also one of the most lethal of cancers, with a five year survival rate of less than 20 percent.

The two large nationwide multi-center studies found the addition of a specialized brush biopsy with computer-assisted laboratory analysis of the specimen (EndoCDx®) to the standard upper endoscopy procedure, significantly increases the detection of both Barrett's esophagus and esophageal dysplasia (still-harmless, but pre-cancerous cells). This large increase in detection was found in the study that included academic centers and a second study that included community-based gastroenterology practices.  

"Academic centers tend to perform numerous forceps biopsies on each of the high risk patients that they follow. Seeking dysplasia in a segment of Barrett's esophagus is like looking for the proverbial needle in a haystack. The fact that the brush biopsy with computer-assisted tissue analysis was found to increase detection by over 40 percent in even these highly experienced esophageal GI specialty centers demonstrates the potential of this technique," said Sharmila Anandasabapathy, MD, chief of Endoscopy, The Mount Sinai Medical Center in New York and lead author of the academic center study.

This large increase in detection was accomplished in just a few minutes, and with no increase in false positives or risk to the patient. When detected at this early, pre-cancerous stage, development of esophageal cancer can typically be prevented.

"If you have frequent heartburn and have never had an upper endoscopy you should make an appointment for one today, especially if you are over 50. If you have had an upper endoscopy and no Barrett's or dysplasia was found, but your heartburn symptoms have persisted, our study teams have found that the new brush biopsy technique may discover abnormal cells which may have been missed by standard biopsy procedures," said Jerome D. Waye, MD, former President of the American College of Gastroenterology and of the American Society for Gastrointestinal Endoscopy, and a study author.

"These two large studies demonstrating the same high degree of benefit from addition of the brush biopsy in two very different patient populations are extremely convincing. There is no reason not to include this test as part of every upper endoscopy with biopsy, and it will soon be available through all of our member hospitals and GI ambulatory surgery centers," said Bruce Wenig, MD, Chairman of Pathology at Continuum Health Partners (Beth Israel Medical Center Hospital, Roosevelt Hospital, and St Luke's Hospital in New York).  Dr. Wenig was not a participant in the study.

Background on Esophageal Adenocarcinoma (EA) and Why Standard Upper Endoscopy Often Fails to Detect its Pre-cancerous Precursors:

Many cases of esophageal adenocarcinoma (EA) are preceded by chronic heartburn. About 30 million Americans report having heartburn at least twice a week. This condition, also known as GastroEsophageal Reflux Disease or GERD, is not only uncomfortable but potentially dangerous. About 10 percent of patients with GERD, or 3 million Americans, will develop small areas of altered cells in their esophagus. This condition, known as Barrett's esophagus, is not harmful in itself. However, each year about 0.5 percent of people with Barrett's will develop esophageal cancer from the Barrett's area of their esophagus.

The current standard of care for preventing EA is for patients with chronic heartburn to see a gastroenterologist every three years for an upper endoscopy of their esophagus. During this procedure, which is typically performed under sedation in the doctor's office or ambulatory surgery center, the doctor will biopsy any areas that appear suspicious for Barrett's esophagus using a small forceps that is passed down the endoscope. Patients who are found to have Barrett's esophagus may then have this procedure performed annually during which the Barrett's area is now repeatedly biopsied to try to detect any pre-cancerous cells (known as dysplasia) that may be within it. As is true with many other cancers, detection and removal of these pre-cancerous (dysplastic) cells can prevent esophageal cancer before it can actually start. For this reason upper endoscopy is performed on over 8 million Americans with heartburn each year.

Gastroenterologists have long known that the very small forceps that they can pass through the narrow biopsy channel of an endoscope can take only a limited, and often random, tissue sample; hence many cases of Barrett's esophagus and dysplasia are currently being missed.

"A long segment of Barrett's esophagus is usually appreciated during endoscopy, however previous studies have shown that a very short segment of Barrett's, which is often not suspected visually is also typically missed by the forceps biopsy," said Dr. Waye.

These two studies tested the esophageal brush biopsy on two widely different patient populations and practice settings to determine its benefit at both points where the current forceps biopsy can fail to detect pre-cancerous disease. In one study performed at eight primary care GI centers, the brush biopsy was tested for its ability to increase the detection of Barrett's esophagus in patients whose only symptom was chronic heartburn or GERD. In the other study, conducted at four academic referral centers on high risk patients, the brush biopsy was tested for its ability to increase the detection of pre-cancerous dysplasia. In both studies the large increase in detection provided by addition of the brush biopsy was approximately the same.

About CDx Diagnostics

CDx Diagnostics (www.cdxdiagnostics.com) is the world's leader in the prevention of cancer of the oral cavity, pharynx, larynx and esophagus through early detection of their pre-cancerous precursors. Clinicians use CDx patented brush biopsy instruments to non-invasively collect a wide area, disaggregated tissue specimen of the entire thickness of the suspect epithelium. This unique tissue specimen is then subjected to specialized, computer-assisted laboratory analysis. These life-saving tests are nationally available to gastroenterologists, otolaryngologists, oral surgeons, periodontists, and dentists. CDx Diagnostics includes tests developed and provided by CDx Laboratories, Inc., Oral Cancer Prevention International, Inc., and its U.S. and international laboratory affiliates. For further information please call (201) 843-5600.


'/>"/>
SOURCE CDx Diagnostics
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Nexavar Significantly Improved Overall Survival in Phase 3 Asia-Pacific Liver Cancer Trial
2. One Year Study of Exenatide Treatment Showed Improved Beta-Cell Function
3. One Year Study of Exenatide Treatment Showed Improved Beta-Cell Function
4. Promising Phase 3 Trial Results Show Novel Biologic Therapy Ustekinumab (CNTO 1275) Significantly Improved Psoriasis
5. Boston Scientifics Next-Generation Stent Shows Improved Clinical Outcomes in Complex Lesions
6. Phase 3 Data Show New Anti-TNF, Golimumab, Significantly Improved Arthritis, Skin and Nail Manifestations in Patients with Psoriatic Arthritis
7. Improved Cornea Surgery Technique Provides Enhanced Transplant Success
8. Post-Hoc Data Show Daily Activity Participation, Independence and Sleep Quality Improved in Adults with Moderate to Severe Rheumatoid Arthritis After Treatment with ORENCIA(R) (Abatacept)
9. Study Finds Fever may Lead to Improved Behavior in Children with Autism Spectrum Disorders
10. Research Identifies Need for Improved Understanding of Sickle Cell Disease in Adulthood
11. Long-Term Soliris(R) Therapy Improved or Stabilized Kidney Function in Patients With PNH
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2017)... , Jan. 23, 2017  Delcath Systems, Inc. (NASDAQ: ... on the treatment of primary and metastatic liver cancers, ... MSN, CRNP, President and Chief Executive Officer of Delcath ... Noble Capital Markets, Thirteenth Annual Investor Conference at the ... Raton, Florida , on Tuesday, January 31, 2017 ...
(Date:1/23/2017)... Research and Markets has announced the addition of the ... to 2025" report to their offering. ... Report Highlights: The report provides ... investment opportunities Market forecasts till 2025, using estimated market ... the business segments, Regions and Countries Key developments and ...
(Date:1/23/2017)... DIEGO , Jan. 23, 2017  Using ... patients at high risk for acute kidney injury ... recommended by globally-recognized care guidelines significantly ... to severe AKI more than 33 percent, according ... in the journal Intensive Care Medicine. ...
Breaking Medicine Technology:
(Date:1/23/2017)... (PRWEB) , ... January 23, 2017 , ... ... the premiere organization in North America for the scientific development, healthcare training and ... Annual Scientific Session, and its 2017 AAT Member Certification Qualification Courses for Technicians, ...
(Date:1/23/2017)... ... , ... "ProRandom is a set of camera tools that allow video editors to integrate up ... X," said Christina Austin - CEO of Pixel Film Studios. , With ProRandom, video ... footage. ProRandom works by using a virtual camera to create the illusion of a ...
(Date:1/23/2017)... ... 2017 , ... “Crossing the Bar”: a moving and eloquent drama depicting ... the Bar” is the creation of published author, Charlotte Hotte, a North Carolina native, ... the inspiration of the book to her sister, Denise, wishes to acknowledge her savior, ...
(Date:1/22/2017)... ... January 22, 2017 , ... Phytocéane invites clients to ... the rest of the world with ZANZIBAR MILKY CREAM. Inspired by the beauty of ... like Virgin Coconut Oil and moisturizing vegetal coral to create this gentle, velvety body ...
(Date:1/21/2017)... ... 21, 2017 , ... Salveo for life, a company that distributes an effervescent ... United States as part of its presence to expand its market reach. , Using ... the productions of nasty toxins as a result of drinking alcohol, eliminating those toxins ...
Breaking Medicine News(10 mins):