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ImmusanT's Epitope-Specific Immunotherapy for Celiac Disease Informs the Potential of Vaccines Against Other Autoimmune Diseases
Date:4/19/2013

span itemprop="name">Ludvig Sollid describe how celiac disease serves as a model to further understand and explore the triggers and drivers of autoimmunity. Celiac disease shares key features with other autoimmune disorders such as susceptibility genes, presence of autoantibodies and destruction of specific cells. By considering MHC (major histocompatibility complex) association, post-translation modifications, the antigen and the tissue, it is possible to design methods that facilitate the identification of potential drivers of autoimmune disease.

"My hope is that the detailed knowledge we have obtained about the pathogenesis of celiac disease can translate into an effective therapy to benefit celiac disease patients. Given the many commonalities between celiac disease and other autoimmune diseases like Type 1 diabetes and rheumatoid arthritis, maybe the experience we gain in celiac disease will eventually benefit patients with other diseases," said Ludvig M. Sollid , MD, PhD, Director, Centre for Immune Regulation; Professor of Medicine, Department of Immunology, University of Oslo; Consultant, Oslo University Hospital-Rikshospitalet; and member of ImmusanT's Scientific Advisory Board.

"Peptide-specific therapy targets in a specific manner the immune cells at the center of the disease process. Celiac disease provides a unique opportunity to bring peptide-specific therapy to the next level. It is a therapeutic approach that has the potential to prevent and cure disease, without inducing general immunosuppression," said Bana Jabri , MD, PhD, Director, University of Chicago Celiac Center; Professor, Department of Medicine, Pathology and Pediatrics, University of Chicago; and Senior Scientific Advisor to ImmusanT.

Dr. Jabri is Co-Chair of the 15th International Celiac Disease Symposium to be hosted by the University of Chicago Cel
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SOURCE ImmusanT, Inc.
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