Navigation Links
ImmusanT Initiates Clinical Trials of Nexvax2 Therapeutic Vaccine for Celiac Disease
Date:9/4/2012

CAMBRIDGE, Mass., Sept. 4, 2012 /PRNewswire/ -- ImmusanT announced today that it has initiated clinical trials in New Zealand, Australia and the U.S. to evaluate Nexvax2®, the first therapeutic vaccine for patients with celiac disease. Nexvax2 is designed to re-establish patients' tolerance to the toxic effects of gluten, a protein in wheat, barley and rye, and allow them to return to a normal diet. There are currently no approved medicines available for people with celiac disease, who must manage their condition by eliminating gluten-containing foods from their diet.

Advancing the earlier Nexvax2 clinical trial, the new program underway in Australia and New Zealand is a randomized, double-blind, placebo-controlled Phase 1b study evaluating multiple ascending doses of Nexvax2 for the induction of gluten tolerance in patients on a gluten-free diet. ImmusanT expects to enroll 84 subjects at approximately four study sites in the two countries in order to evaluate safety, tolerability and pharmacokinetics, and to select doses for investigation in subsequent studies.

The second study, a randomized, double-blind, placebo-controlled Phase 1 trial being conducted in the U.S. is to determine the safety, tolerability and pharmacokinetic profile of Nexvax2 in patients with celiac disease well controlled by a gluten-free diet. ImmusanT plans to enroll 30 adult subjects at approximately four trial sites.

"We are kicking-off a robust clinical program that we hope demonstrates Nexvax2 dramatically reduces the body's immune response to dietary gluten so patients can resume a normal diet and return to good health," said Patrick H. Griffin, M.D., Chief Medical Officer of ImmusanT. "Our clinical development program will allow us to further examine the role of antigen-specific T cells in celiac disease activation and in the re-establishment of tolerance to gluten."

"There has been tremendous enthusiasm about Nexvax2 from patients and the medica
'/>"/>

SOURCE ImmusanT Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. ImmusanT Relocates Offices to State-of-the-Art Innovation Facility
2. Asubio Initiates Landmark Clinical Study in Spinal Cord Injury
3. CSL Behring Initiates Study of Subcutaneous Administration of C1-esterase Inhibitor in Patients with Hereditary Angioedema
4. Isis Initiates Phase 2 Study of ISIS-APOCIIIRx in Patients with Hypertriglyceridemia
5. Alder BioPharmaceuticals Inc. Initiates Phase 1 Clinical Study of Antibody Therapeutic Candidate for Treatment of Migraine, ALD403
6. Oncos Therapeutics Initiates Phase I Clinical Study of CGTG-102, an Oncolytic Adenovirus for the Treatment of Solid Tumor Cancers
7. MAQUET Initiates Class I Recall of the FLOW-i Anesthesia System
8. Stryker Initiates Voluntary Product Recall of Modular-Neck Stems
9. Inovio Initiates H1N1 Universal Influenza Vaccine Clinical Trial Targeting Over-65 Population, Which Represents 90% of Flu Deaths
10. Grifols Initiates Safety Study of Inhaled Alpha1-Proteinase Inhibitor (Human) Following Orphan Drug Designation for Cystic Fibrosis
11. Empire Asset Management Co. Initiates Coverage on Transcept Pharmaceuticals Inc., (NASDAQ: TSPT)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... , Sept. 30, 2014 BioStructures, LLC ... American Association of Tissue Banks (AATB), it was ... Executive Officer. Accreditation follows an intensive ... specially trained AATB inspector.  It establishes that the ... the facility meets or exceeds the standards set ...
(Date:9/30/2014)... , Sept. 30, 2014  Proteomics is a ... a new report from Kalorama Information.  The healthcare market ... occurred in proteomics in the past two years.  ... agreements between private proteomic companies and academic institutions, ... novel proteomics innovator companies.  Kalorama observed the industry ...
(Date:9/30/2014)... , September 30, 2014 ... the CSF (Cerebrospinal Fluid) backflow of the Eldor spinal ... of the single hole pencil point spinal needles of ... Braun. Spinal anesthesia is an excellent type ... Orthopedics, Urology, General Anesthesia, etc. It is ...
Breaking Medicine Technology:Biostructures, LLC Earns AATB Accreditation 2Report: Race for Proteomics Knowledge Spurs Investment and Partnerships 2Report: Race for Proteomics Knowledge Spurs Investment and Partnerships 3
... YORK, March 28, 2011 Havas Drive, the innovation ... of patient-centric services geared toward persons with disabilities and ... Smith—a nationally recognized authority on Web accessibility with a ... Pentagon Library, Kent State,s Knowledge Management program and the ...
... Inc. (Nasdaq: KERX ) (the "Company") today ... presented at the upcoming 102nd annual meeting of the ... in Orlando, Florida, from April 2-6, 2011. Perifosine, the ... Akt activation in the phosphoinositide 3-kinase (PI3K) pathway, is ...
Cached Medicine Technology:Havas Drive Launches New Services Aimed at Improving Digital and Web Accessibility 2Keryx Biopharmaceuticals Announces Two Poster Presentations on KRX-0401 (Perifosine) at Upcoming American Association for Cancer Research (AACR) Annual Meeting 2Keryx Biopharmaceuticals Announces Two Poster Presentations on KRX-0401 (Perifosine) at Upcoming American Association for Cancer Research (AACR) Annual Meeting 3
(Date:9/30/2014)... September 30, 2014 A new study ... University studied the impact of stress on metabolism after eating ... french fries from a fast food restaurant, about 930 calories ... metabolism for 20 minutes every hour for 7 hours, conducting ... that women who had experienced a stressful event in their ...
(Date:9/30/2014)... leading cause of allergy-related sudden deaths in the U.S., ... to 2010, conducted by researchers at Montefiore ... Medicine of Yeshiva University . The study, published online ... Immunology , also found that the risk of fatal ... and African-Americans and that such deaths increased significantly in ...
(Date:9/30/2014)... Las Vegas, NV (PRWEB) September 30, 2014 ... that is helping people perform better in and out of ... performance, and memory has caught the attention of Shane Michaels, ... the day-to-day grind, fatigue is the reason most people simply ... want, whether that means staying focused at work, getting the ...
(Date:9/30/2014)... September 30, 2014 With the ... strains emerging every day, it’s a perfect time ... The EnviroShield system is an electro-static disinfectant delivery ... to surface normally missed with spray-on disinfectant applicators. ... that adds an electrostatic negative charge to the ...
(Date:9/30/2014)... Clearwater, FL (PRWEB) September 30, 2014 ... (colon), declines with age, poor diet, and stress, so ... beneficial bacteria.* Each capsule of Ultimate Flora™ Men’s ... 58 billion cultures from 7 Bifidobacteria strains to support ... gas tends to build up, and 32 billion cultures ...
Breaking Medicine News(10 mins):Health News:NutriGold Urges Every Woman To Read a Recent Study About Diet and Stress 2Health News:NutriGold Urges Every Woman To Read a Recent Study About Diet and Stress 3Health News:Comprehensive Study of allergic deaths in US finds medications are main culprit 2Health News:Elevate: Review Exposes Blue Star Nutraceutical’s Latest Supplement for Ultimate Brain Function, Focus, and Energy 2Health News:Columbus Janitorial Company Announces New Disinfecting System for your workplace 2Health News:ReNew Life Introduces Ultimate Flora™ Men’s Complete Probiotic 90 Billion—Comprehensive Probiotic Support Just for Men 2
... usually reserved,for lighthearted fun and entertainment, the hallways ... kind of gathering Monday, as child-health,and education experts ... trends in Jordan. Her Majesty Queen Rania Al ... Jordan there, bringing some,welcomed news about the Kingdom,s ...
... estimates 750,000, mostly males, are hooked , , MONDAY, May ... and young adults are problem gamblers according to researchers ... , Problem gambling is defined as gambling associated ... more than you intended or stealing money to gamble. ...
... has targeted an,expansion of its human health and performance ... commercial customers based on the success the,company has had ... other,advanced human support services to the space program., ... human performance and engineering services with an emphasis on,risk ...
... All Natural 100% Juice Superfood Smoothie Line has ,Lifeguard(TM) ... ... Sun Shower(TM) is proud to,introduce a new line of all ... Shower(TM) with the added nutritional,benefits of "Lifeguard(TM) Protection," a fortification package ...
... expansion of serialization initiatives, CRANBURY, N.J., ... Packaging Execution Systems (PES) for the pharmaceutical,industry, ... its sales, central engineering and professional services,teams. ... these areas to support,rapid worldwide deployments; specifically, ...
... Pandemic Influenza Initiatives Also,on the Agenda, WASHINGTON, ... Services (HHS) Secretary Mike Leavitt is visiting the ... efforts to improve the,safety of products on which ... The week-long trip to Beijing and Shanghai includes ...
Cached Medicine News:Health News:Queen Rania Launches Situation Analysis of Children in Jordan Highlighting Jordan's Progress in Improving Quality of Life; 6 Ministers Commit to Further Improving Results 2Health News:Queen Rania Launches Situation Analysis of Children in Jordan Highlighting Jordan's Progress in Improving Quality of Life; 6 Ministers Commit to Further Improving Results 3Health News:Queen Rania Launches Situation Analysis of Children in Jordan Highlighting Jordan's Progress in Improving Quality of Life; 6 Ministers Commit to Further Improving Results 4Health News:Problem Gambling Common Among Young Adults 2Health News:Wyle Targets New Customers for Expanded Human Health and Performance Capabilities and Services 2Health News:New Sun Shower(TM) Superfood Smoothies 2Health News:New Sun Shower(TM) Superfood Smoothies 3Health News:Systech Augments Key Departments to Drive Operational Excellence and International Support 2Health News:Systech Augments Key Departments to Drive Operational Excellence and International Support 3Health News:Secretary Leavitt Travels to the People's Republic of China to Check Up on Efforts to Improve Product Safety 2
Prolactin EIA Reproductive Markers 025-BC-1037...
FSH EIA Reproductive Markers 025-BC-1029 Follicle Stimulating Hormone...
... (pregn-4-ene-3, 20-dione) is a C21 steroid hormone ... bond between C-4 and C-5 (?4).,This steroid ... in conjunction with estrogens, regulates,the accessory organs ... particularly important in preparing the,endometrium for the ...
... also known as Kininase II, is a ... weight of at least 129,000. The structure ... chain, a polysaccharide residue and a zinc ... cell types such as neuronal cells and ...
Medicine Products: