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Immunotherapy in Oncology Drug Pipeline Update 2011
Date:9/7/2011

ing complex scaffold activity

- RNA-directed DNA polymerase activity

- Serine-type peptidase activity

- Structural constituent of cytoskeleton

- Structural molecule activity

- T cell receptor activity

- Transcription factor activity

- Transcription regulator activity

- Translation regulator activity

- Transmembrane receptor activity

- Transmembrane receptor protein tyrosine kinase activity

- Transporter activity

- Unclassified

- Unknown

Identified targets are categorized into 27 (25) different primary and alternate sub-cellular localizations:

- Apical membrane

- Cell junction

- Cell surface

- Centrosome

- Clathrin-coated vesicle

- Cytoplasm

- Cytoplasmic vesicle

- Cytoskeleton

- Cytosol

- Endoplasmic reticulum

- Endosome

- Extracellular

- Extracellular matrix

- Golgi apparatus

- Immunological synapse

- Integral to membrane

- Lysosome

- Mitochondrion

- n/a

- Nucleolus

- Nucleus

- Perinuclear region

- Perinuclear vesicle

- Plasma membrane

- Secreted

- Secretory granule

- Soluble fraction

Note: You are able to find and sort drugs according to target gene name, molecular function of target, and target localization from drop-down menus in the application.

Target Expression Profile

Direct links are provided from inside the application to 339 (282) protein expression profiles of 231 (201) drug targets in various human tissues and cancer types, cell lines and primary cells, including up to:

- 48 different normal tissue types

- 20 different types of cancer

- 47 cell lines

- 12 samples of primary blood cells

Pathway Referals

Identified targets have been cross referenced against their involvement in different cellular p
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