Navigation Links
Immunomic Therapeutics Begins Phase I Japanese Red Cedar JRC-LAMP-Vax Vaccine Safety Study

LANCASTER, Pa. and ROCKVILLE, Md., Nov. 8, 2012 /PRNewswire/ -- Immunomic Therapeutics, Inc., ("ITI," Lancaster, PA) a leader in developing novel allergy immunotherapies, announced today that it has dosed the first patient in a Phase I clinical trial of its lead candidate, JRC-LAMP-vax™ vaccine, at its clinical site in Honolulu, Hawaii. Initial subjects include Japanese ex-patriates previously exposed to Japanese red cedar, or "Sugi," as it is known in Japan. JRC-LAMP-vax vaccine is a plasmid-based DNA vaccine that will be studied for its safety and immunological activity in the treatment of patients with rhino-conjunctivitis symptoms caused by allergic reaction to Japanese red cedar pollen. Enrollees in the study each received the first of a four (4) dosing vaccine regimen and were followed for 3 hours; no adverse events were observed in these patients.

ITI intends to complete enrollment in the study in November, the dosing of all patients early in 2013, and to follow up with a Phase II trial beginning in 2013. ITI's CEO, Dr. William Hearl, commented, "The successful initiation of this clinical study marks a significant milestone in the history of Immunomic Therapeutics. We are both pleased and excited that we are now a clinical - stage company. We are looking forward to completing the study and advancing the development of this important vaccine and other LAMP-vax™ vaccines."

Dr. Bruce F. Mackler, Vice President of Regulatory and Clinical Affairs, Immunomic Therapeutics, Inc., indicated that "ITI is committed to the rapid expansion of its clinical program based on the outcome of this first Japanese red cedar vaccine. We plan to move rapidly into the clinical testing of the multivalent vaccine in naturally sensitive Japanese ex-patriates as well as U.S. subjects with sensitivity to mountain cedar. This study will support our food allergy program which will treat peanut allergy in sensitive patients; that study should begin in 2013."

In Japan, it is estimated that up to 45% of the Japanese people are allergic to Japanese red cedar pollen. In North America, especially Texas, individuals suffer from a closely related allergy to mountain cedar pollen. During this Phase I study, ITI will also be monitoring the response to mountain cedar allergens in these subjects.

Key to the success of ITI's vaccines is the incorporation of LAMP Technology. Pre-clinical studies have documented that LAMP-based vaccines induce a protective antibody IgG immune response consistent with a preferential MHC-II immune system presentation induced by LAMP. Multiple studies applying LAMP Technology in human clinical trials have shown that incorporation of the LAMP element dramatically increases the CD4+ response to the target antigen. In addition to providing important safety data on LAMP, the studies confirm that LAMP vaccines activate the human immune system. LAMP-based vaccines hold potential for the development of potent vaccines for treatment of allergies, infectious disease and cancer.

About Immunomic Therapeutics Immunomic Therapeutics, Inc. (ITI) is a privately-held clinical stage biotechnology company headquartered in Lancaster, PA with lab facilities in Rockville, MD. ITI is developing next generation vaccines based on the patented LAMP Technology. Our LAMP-vax™ vaccine platform significantly increases the effectiveness of the immune response to nucleic acid vaccines while simplifying overall vaccine design and delivery, yielding safer, more cost-effective human and animal therapies. Our LAMP constructs have been validated in human clinical trials for cancer and have been applied to a wide breadth of targets including allergy, cancer and infectious diseases. For more information about ITI and LAMP Technology please visit

Dr. Bill Hearl, President / CEO
Immunomic Therapeutics, Inc.
Phone: 1-717-327-1919


SOURCE Immunomic Therapeutics, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. Stemline Therapeutics Lead Clinical Candidate SL-401 Induces a Complete Response in a Patient with a Drug-Refractory Plasmacytoid Dendritic Cell Neoplasm
2. Echo Therapeutics Announces Third Quarter 2012 Financial Results
3. Orexigen Therapeutics Reports Financial Results for the Third Quarter Ended September 30, 2012
4. Particle Sciences Develops Novel Ocular Formulation for Eyeon Therapeutics
5. Halozyme Therapeutics To Present At The Lazard Capital Markets 9th Annual Healthcare Conference
6. Novelos Therapeutics Closes $2 Million Private Placement
7. US Allows Two Key Patents for Silence Therapeutics
8. United Therapeutics Corporation Reports Third Quarter 2012 Financial Results
9. Cell Therapeutics, Inc. (CTI) Reduces Net Loss for Third Quarter and Nine Months Ended September 30, 2012 Compared to Same Periods in 2011
10. Novelos Therapeutics Announces Enrollment of First Patient in Solid Tumor Imaging Trial with I-124-CLR1404 (LIGHT) Cancer-targeted PET Imaging Agent at UW Carbone Cancer Center
11. United Therapeutics Announces Collaboration With Ascendis Pharma To Develop Self-Injectable Treprostinil For Pulmonary Arterial Hypertension
Post Your Comments:
(Date:12/1/2015)... 2015 /PRNewswire/ -- Royal Philips  (NYSE: ... X-ray imaging software that produces high-contrast images for all ... a grid, at the 2015 Radiological Society of ... is Philips, first digital imaging solution providing grid-like contrast ... clinician,s workflow and supports "first-time-right imaging" by decreasing the ...
(Date:12/1/2015)... PUNE, India , December 1, 2015 ... new market research report "Immunotherapy Drugs Market by Type of ... Vaccines), Checkpoint Inhibitors), Epidemiology, Regulatory and Pipeline Analysis - Global ... Market is poised to reach USD 73,529.2 Million by 2020 ... 12.8% from 2015 to 2020. Browse ...
(Date:12/1/2015)... MASON, Ohio , Dec. 1, 2015 /PRNewswire/ ... enhancement to its GeneSight® Psychotropic test giving healthcare providers ... make medication decisions for patients suffering from depression, ... and other behavioral health conditions. ...   --> With the addition of ...
Breaking Medicine Technology:
(Date:12/1/2015)... ... 01, 2015 , ... Trustify is proud to announce the success of the ... an organization dedicated to ending domestic violence. , Trustify and Becky’s Fund have joined ... survivors of domestic violence. Trustify is also proud to announce the launch of the ...
(Date:12/1/2015)... Miami, FL (PRWEB) , ... December 01, 2015 , ... ... products, announces the Multi Jar, a container patent that allows for easier packing and ... in the US is worth $90 billion," says Scott Cooper, CEO and Creative Director ...
(Date:12/1/2015)... ... December 01, 2015 , ... Integrated Rental ... by Jordan Industries International, LLC (“JII”). , With support from JII, Integrated Rental ... services to hospitals, surgery centers, clinics, research labs and medical facilities across the ...
(Date:12/1/2015)... ... December 01, 2015 , ... Baptist Medical Center Jacksonville has ... the only hospital in the region providing what is known as the world’s ... patients were revealed recently at a medical conference and published in The New ...
(Date:12/1/2015)... Cambridge, MA (PRWEB) , ... December 01, 2015 , ... ... 2013, in part due to decreases in utilization of hospital and nonhospital care, according ... report, CompScope™ Medical Benchmarks for Louisiana, 16th Edition , found medical payments per ...
Breaking Medicine News(10 mins):