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Immunomedics Announces Preclinical Therapy Results of SN-38 Immunoconjugate for Colorectal Cancer
Date:1/20/2009

creased 4-fold to 86 days compared to untreated animals, and was significantly better than all controls, including irinotecan administered at its maximum tolerated dose, which is a 50-fold increase in the amount of free drug than SN-38 in the immunoconjugate dose.

"We believe these results suggest that targeted chemotherapy of colorectal cancer with labetuzumab-SN-38 should enhance the bioavailability and reduce the toxicity of the clinically validated drug, irinotecan," commented Cynthia L. Sullivan, President and CEO. "More preclinical evidences are being collected to support the human testing of this new drug immunoconjugate," she added.

About Immunomedics

Immunomedics is a New Jersey-based biopharmaceutical company primarily focused on the development of monoclonal, antibody-based products for the targeted treatment of cancer, autoimmune and other serious diseases. We have developed a number of advanced proprietary technologies that allow us to create humanized antibodies that can be used either alone in unlabeled or "naked" form, or conjugated with radioactive isotopes, chemotherapeutics or toxins, in each case to create highly targeted agents. Using these technologies, we have built a pipeline of therapeutic product candidates that utilize several different mechanisms of action. We also have a majority ownership in IBC Pharmaceuticals, Inc., which is developing a novel Dock-and-Lock (DNL) methodology for making fusion proteins and multifunctional antibodies, and a new method of delivering imaging and therapeutic agents selectively to disease, especially different solid cancers (colorectal, lung, pancreas, etc.), by proprietary, antibody-based, pretargeting methods. We believe that our portfolio of intellectual property, which includes approximately 134 patents issued in the United States and more than 300 other patents issued worldwide, protects our product candidates and technologie
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SOURCE Immunomedics, Inc.
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