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ImmuneRegen BioSciences Reports Material Transfer Agreement with VaxGen, Inc.
Date:8/19/2007

VaxGen's Recombinant Protective Antigen Anthrax Vaccine to be tested with

ImmuneRegen's Adjuvant

SCOTTSDALE, Ariz., Aug. 7 /PRNewswire-FirstCall/ -- ImmuneRegen BioSciences, a wholly owned subsidiary of IR BioSciences Holdings, Inc. (OTC Bulletin Board: IRBO), today announced it has finalized a Material Transfer Agreement (MTA) with VaxGen Inc. (Pink Sheets: VXGN.PK). As part of the agreement, ImmuneRegen will receive the pharmaceutically active ingredient of VaxGen's anthrax vaccine candidate, recombinant Protective Antigen, or rPA, to be tested at one of ImmuneRegen's partnering labs. Commercial terms of the MTA were not disclosed.

VaxGen's rPA102 anthrax vaccine is composed of a purified rPA and an aluminum salt adjuvant routinely used in many vaccines. ImmuneRegen will be testing for adjuvant activity of ImmuneRegen's Viprovex(R) in combination with VaxGen's rPA.

"We are hoping to find that our compound, Viprovex, will demonstrate adjuvant activity in a rabbit model with the VaxGen vaccine," said Hal Siegel, Ph.D., Senior Director of Product Development and Regulatory Affairs, ImmuneRegen BioSciences, Inc. "From work we and others have already performed, we hope the adjuvant activity we recently reported in our studies with influenza vaccines in mice will be mirrored in testing of Viprovex with VaxGen's rPA antigen."

Initial studies in a well-established mouse model system have revealed that Viprovex can both prophylactically and therapeutically have positive effects in mice exposed to lethal doses of anthrax. Tests results indicated that animals exposed to lethal doses of anthrax spores were treated with different doses of Viprovex either before or after anthrax exposure and survival ranged from 20% to 70%.

The MTA with ImmuneRegen BioSciences is separate from VaxGen's effort to partner its recombinant anthrax vaccine program with another company for the purpose of carrying on the development and c
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SOURCE ImmuneRegen BioSciences

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