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ImmunGene and Collaborators Report Positive Results in Pre-clinical Studies of Novel Anti-CD20 Antibody-Interferon Alpha Fusion Protein
Date:6/3/2013

pare healthy cells and may reduce many of the known toxic effects of systemically administered cytokines while greatly enhancing the anti-tumor activity of antibodies," said Iqbal Grewal , PhD, DSc, Chief Scientific Officer at ImmunGene. "We are encouraged by the evidence of antitumor activity of IGN002 observed in pre-clinical studies in rituximab-resistant tumor models and are preparing for an IND filing for IGN002 in the second half of 2014."

About IGN002

IGN002, a fusion molecule of anti-CD20 antibody and interferon alpha, two clinically validated anti‑cancer drugs, is designed to to deliver therapeutically effective doses of interferon alpha to CD20-expressing lymphoma cells to exert direct suppression of tumor cell growth and engage multiple anti-tumor immunologic effector mechanisms, leading to substantially improved efficacy while avoiding the systemic toxicity seen with free interferon.

As announced in May 2013, Valor Biotherapeutics, a joint venture between ImmunGene and Caliber Biotherapeutics, has partnered with The Leukemia & Lymphoma Society (LLS) to co-fund the completion of pre-clinical development, manufacturing, and a phase I clinical trial for IGN002.

About ImmunGene, Inc.

ImmunGene is a privately held biotechnology company focused on the development of proprietary antibody-cytokine fusion technology and monoclonal antibody-based therapies to treat cancer, autoimmune disorders, and other diseases. ImmunGene has several programs at various stages of development. ImmunGene is funded by federal government grants including the NIH-SBIR and by private investors including several biotechnology executives. More information can be found at: www.immungene.com.

About Valor Biotherapeutics, LLC

Valor Biotherapeutics, a joint venture between ImmunGene and Caliber Biotherapeutics (www.caliberbio.
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SOURCE ImmunGene, Inc.
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