Navigation Links
ImmunGene and Collaborators Report Positive Results in Pre-clinical Studies of Novel Anti-CD20 Antibody-Interferon Alpha Fusion Protein

THOUSAND OAKS, Calif., June 3, 2013 /PRNewswire/ -- ImmunGene, Inc. today announced that pre‑clinical studies of its novel anti‑CD20 antibody-interferon alpha fusion protein, IGN002, demonstrated superior anti‑lymphoma activity against numerous cell lines in vitro and against established human xenograft tumors grown in mice. The findings were presented in the Developmental Therapeutics - Immunotherapy poster session on Saturday, June 1, at the 2013 annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago (abstract #3024).

"The unique combination of IGN002's potent anti-proliferative and direct apoptosis effects in addition to antibody‑dependent cellular cytotoxicity and enhanced complement-dependent cytotoxicity has not been seen with any other CD20‑targeted agent," stated John Timmerman , MD, Associate Professor of Medicine, University of California, Los Angeles (UCLA) Division of Hematology‑Oncology and senior author of the study.

The presentation highlights the rapid progress being made in the development of a new class of anti-cancer biotherapeutics which use antibody-interferon alpha fusion technology. This technology was developed by Sherie Morrison , PhD, Distinguished Professor of Microbiology, Immunology, and Molecular Genetics at UCLA. Part of the pre-clinical research for IGN002 has been done in collaboration with the laboratories of Timmerman and Morrison, who are members of UCLA's Jonsson Comprehensive Cancer Center, and funded by The Leukemia & Lymphoma Society, the UCLA/CalTech Joint Center for Translational Medicine, and the NIH/National Cancer Institute.

"Antibody‑fusion proteins are designed to be inactive at therapeutic doses in the bloodstream while highly potent in targeting and killing cancer cells. We believe this approach is likely to spare healthy cells and may reduce many of the known toxic effects of systemically administered cytokines while greatly enhancing the anti-tumor activity of antibodies," said Iqbal Grewal , PhD, DSc, Chief Scientific Officer at ImmunGene. "We are encouraged by the evidence of antitumor activity of IGN002 observed in pre-clinical studies in rituximab-resistant tumor models and are preparing for an IND filing for IGN002 in the second half of 2014."

About IGN002

IGN002, a fusion molecule of anti-CD20 antibody and interferon alpha, two clinically validated anti‑cancer drugs, is designed to to deliver therapeutically effective doses of interferon alpha to CD20-expressing lymphoma cells to exert direct suppression of tumor cell growth and engage multiple anti-tumor immunologic effector mechanisms, leading to substantially improved efficacy while avoiding the systemic toxicity seen with free interferon.

As announced in May 2013, Valor Biotherapeutics, a joint venture between ImmunGene and Caliber Biotherapeutics, has partnered with The Leukemia & Lymphoma Society (LLS) to co-fund the completion of pre-clinical development, manufacturing, and a phase I clinical trial for IGN002.

About ImmunGene, Inc.

ImmunGene is a privately held biotechnology company focused on the development of proprietary antibody-cytokine fusion technology and monoclonal antibody-based therapies to treat cancer, autoimmune disorders, and other diseases. ImmunGene has several programs at various stages of development. ImmunGene is funded by federal government grants including the NIH-SBIR and by private investors including several biotechnology executives. More information can be found at:

About Valor Biotherapeutics, LLC

Valor Biotherapeutics, a joint venture between ImmunGene and Caliber Biotherapeutics (, is focused on the clinical development and commercialization of the next generation of monoclonal antibody-based therapeutics to treat cancer. For more information, please visit:

SOURCE ImmunGene, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. Caliber and ImmunGene Launch Valor Biotherapeutics, a Joint Venture to Develop Antibody-Interferon Fusion Therapeutics to Treat Cancers
2. The Leukemia & Lymphoma Society, Valor Biotherapeutics and ImmunGene Create Partnership to Advance Novel Therapy for Non-Hodgkin Lymphoma Patients
3. Novelos Therapeutics And Academic Collaborators Present Three Posters At 2012 World Molecular Imaging Congress
4. Cell Therapeutics, Inc. (CTI) to Report First Quarter Financial Results on April 20
5. Report Presents a Framework for Successful New Oncology Product Launches in the Pharmaceutical Sector
6. WuXi PharmaTech Files 2011 Annual Report on Form 20-F
7. Qmed, the Leading Global MedTech Industry Resource, Partners with Clarimed, to Provide the Medical Manufacturing and Healthcare Industry with FDA Reports on Adverse Events
8. Sigma-Aldrich (NASDAQ: SIAL) Reports Q1 2012 Diluted EPS of $0.96, With Diluted Adjusted EPS of $0.99. Sales Increase 5% for Q1 2012. Full Year 2012 Diluted Adjusted EPS Outlook of $3.90 to $4.05 Reaffirmed.
9. Kelyniam Global Inc. Reports Record Cranial Implant Revenues in the 1st Quarter of 2012
10. Varian Medical Systems Reports Results for Second Quarter of Fiscal Year 2012
11. Mylan Reports Q1 2012 Adjusted Diluted EPS of $0.52, an 18% Increase Over Prior Year Quarter
Post Your Comments:
(Date:11/24/2015)... -- Teledyne DALSA , a Teledyne Technologies company and ... its CMOS X-Ray detector for mammography at the ... 3, at McCormick Place in Chicago . ... imaging will be on display in the South Hall, Booth ... X-Ray detectors is the industry benchmark for high speed imaging ...
(Date:11/24/2015)... , Nov. 24, 2015  Boston Scientific Corporation (NYSE: ... Oppenheimer 26th Annual Healthcare Conference on December 8, in ... Susie Lisa , vice president, Investor Relations, will participate ... beginning at approximately 8:35 a.m. ET. --> ... in a 30-minute question-and-answer session with the host analyst ...
(Date:11/24/2015)... 2015   Renowned ... deliver s advice and insights on supplements ... More than 50% of Dubai ... to the DHA   femMED launches comprehensive solutions for women ... Dubai residents are not consuming enough to keep themselves ...
Breaking Medicine Technology:
(Date:11/25/2015)... (PRWEB) , ... November 25, 2015 , ... ... for Tuberous Sclerosis Complex (TSC), as well as raising public awareness of the ... they need it—presented a third donation of $35,000 to bolster progress at the ...
(Date:11/25/2015)... ... 25, 2015 , ... Bunion Bootie , the newest ... of the early holiday shopping season. Starting Wednesday November 25th, Bunion Booties are ... Friday promotional pricing is in addition to any automatic discounts applied when buying ...
(Date:11/24/2015)... ... ... Dr. Todd S. Afferica, a noted general dentist in Norcross, GA ... Afferica now uses the BIOLASE WaterLase iPlus 2.0™ in many of his dental procedures. ... traditional cutting tools, such as the scalpel and high-speed drill, which can both cause ...
(Date:11/24/2015)... ... , ... Charitable giving is at its peak during the holidays. In ... of the year totalling over $358 billion in 2014. With more than 1.5 ... those individuals who want to “give back” during the holidays. , “With so many ...
(Date:11/24/2015)... (PRWEB) , ... November 25, 2015 , ... ... technologies and development solutions for drugs, biologics, consumer health and global clinical supply ... present at the upcoming Clinical Trial Supply East Asia Conference, to be held ...
Breaking Medicine News(10 mins):